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Öğe Acute effect of palonosetron on electrocardiographic parameters in cancer patients: a prospective study(SPRINGER, 2012) Yavas, C.; Dogan, U.; Yavas, G.; Araz, M.; Ata, O. YavasPalonosetron is a novel 5-hydroxytryptamine(3) (5 HT3) receptor antagonist, which has been shown to be superior to first generation 5 HT3 receptor antagonists regarding the prevention of acute, delayed and overall chemotherapy-induced nausea and vomiting. First generation 5 HT3 receptor antagonists may induce electrocardiographic changes of heart rate and repolarization. The acute cardiac effect of palonosteron is unknown. The purpose of this study is to determine acute effects of palonosetron on electrocardiographic (ECG) parameters in cancer patients. The study had a prospective design. Seventy-six cancer patients with normal cardiac function who received palonosetron for prevention of chemotherapy-induced nausea and vomiting were enrolled. Standard 12-lead ECG recordings were performed at baseline and 30 min after palonosetron administration. P wave durations and corrected QT intervals were measured; P wave dispersion (Pd) and QTc dispersion were calculated. Median heart rate did not differ among 76 patients enrolled before and after palonosetron administration (p: 0.6). Systolic and diastolic blood pressures were not significantly different before and after palonosteron (p values 0.9 and 0.3, respectively). Although median QT min value was higher after palonosetron administration than before palonosetron administration, the difference was not statistically significant (p: 0.6). Palonosetron seems to have no acute arrhythmogenic potential.Öğe ASSOCIATION OF VENTRICULAR SEPTAL RUPTURE, INFECTIVE ENDOCARDITIS AND INTRACARDIAC THROMBUS FOLLOWING MYOCARDIAL INFARCTION: FIRST CASE REPORT(ELSEVIER IRELAND LTD, 2011) Tekinalp, M.; Dogan, U.; Duman, C.; Soylu, A.[Abstract not Available]Öğe Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization(VERDUCI PUBLISHER, 2012) Dogan, U.; Yavas, G.; Tekinalp, M.; Yavas, C.; Ata, O. Y.; Ozdemir, K.Background: 5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) and regarded to have a high safety profile. However, several electrocardiographic changes and cardiac arrhythmias have been reported due to administration of 5-HT3 antagonists. Only prolongation of QT interval has been investigated as an index of potential for life-threatening arrhythmias in adult patients using 5-HT3 antagonists. Recently, increase in transmural dispersion of repolarization (TDR) has been proposed as a more reliable determinant of arrhythmogenic potential. Aim: To assess the effects of palonosetron, a second-generation 5-HT3 antagonist, on the T-wave peak to T-wave end (TpTe) interval which has been proposed as a reliable index of spatial TDR. Patients and Methods: A total of 50 consecutive cancer patients (aged: 57 +/- 12 years) who were scheduled to receive emetogenic chemotherapy were included to the study. Baseline12-lead electrocardiography (ECG) recordings were obtained. Then, all patients received 8 mg intravenous dexamethasone followed by a single dose of 0.25 mg intravenous palonosetron administered over 30 seconds. A second ECG was performed 30 minutes after the administration of palonosetron. Indices of cardiac repolarization and TOR before and after the administration of palonosetron were compared. Results: In comparison with baseline there was no statistically significant change in any of the heart rate-corrected parameters, including QT(c) (lead V-5), QT(maxc), QT(minc), QT(cd), TpTe (V-5), TpTe(max), TpTe(min), TpTe(d) and TpTe/QT (V-5). Conclusions: Palonosetron does not have any significant effect on QT(c) and TpTe intervals. It might be the drug of choice for prophylaxis of CINV in cancer patients receiving chemotherapy with known cardiotoxic potential or who have pre-existing cardiac disease that predispose them to drug-induced arrhythmias.Öğe AN UNUSUAL ELECTROCARDIOGRAPHIC PRESENTATION OF OCCLUSION OF THE LEFT ANTERIOR DESCENDING ARTERY: INFEROLATERAL ST SEGMENT ELEVATION(ELSEVIER IRELAND LTD, 2011) Dogan, U.; Tekinalp, M.; Can, I.; Aribas, A.[Abstract not Available]
