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    Diagnostic and prognostic value of procalcitonin and phosphorus in acute mesenteric ischemia
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2011) Karabulut, Keziban; Gul, Mehmet; Dundar, Zerrin Defne; Cander, Basar; Kurban, Sevil; Toy, Hatice
    BACKGROUND In this study, using an animal model of acute mesenteric ischemia (AMI), we investigated the possible use of procalcitonin and phosphorus in the early diagnosis of AMI. METHODS In this study, 21 New Zealand rabbits were used. Subjects were allocated into three groups as Control, Sham and Ischemia. No intervention was performed in the subjects in the Control group. In the subjects in the Sham and Ischemia groups, laparotomy was performed with midline incision. In the Ischemia group, the superior mesenteric artery was found and tied after laparotomy. Blood was drawn from the animals in all groups at 0, 1, 3 and 6 hours, and procalcitonin and phosphorus levels were studied in these samples. RESULTS In the Ischemia group, the increase in the levels of serum phosphorus and procalcitonin was found to be statistically significant compared to the Control and Sham groups (p < 0.05). The levels of phosphorus and procalcitonin were detected to increase from the 1st hour after ischemia onset, and the increase continued for the following 6 hours (p < 0.05). CONCLUSION Phosphorus and procalcitonin may be important parameters for use in the early diagnosis and prognosis of AMI.
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    Prognostic value of serum zinc levels in critically ill patients
    (W B SAUNDERS CO-ELSEVIER INC, 2011) Cander, Basar; Dundar, Zerrin Defne; Gul, Mehmet; Girisgin, Sadik
    Purpose: We investigated the hypothesis that a decline in serum zinc concentrations among critically ill patients is related to mortality, length of stay in the intensive care unit, and Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment (SOFA) scores. Materials and Methods: All the patients (>= 18 years old) presenting to the intensive care unit from September 2009 through November 2009 were enrolled the study. Patients' demographic characteristics and Acute Physiology and Chronic Health Evaluation and SOFA scores were recorded. Blood samples were collected within 24 hours after admission and analyzed for serum zinc, copper, C-reactive protein, and albumin levels. Patients were followed up for mortality and length of stay in the intensive care unit for 28 days. Results: A total of 36 patients, with a median age of 70.5 years (range, 18-87 years), were enrolled during the study period. Serum zinc levels were found to be inversely correlated with SOFA scores (r = -0.41, P < .01). Patients with SOFA scores of 8 or higher had significantly lower serum zinc levels compared with patients with SOFA scores lower than 8 (6.74 +/- 1.63 and 9.17 +/- 2.76 mu mol/L, respectively; P < .01). Conclusion: The result of this study supports the fact that organ failure and critical illness lead to a decline in serum zinc concentrations and that administration of zinc may be beneficial for critically ill patients. (C) 2011 Elsevier Inc. All rights reserved.