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  • Küçük Resim Yok
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    Effect of morphine sulphate on histopathologic changes in lung tissue after ischemia reperfusion injury [İskemi reperfüzyon hasari sonrasinda akciğer dokusunda meydana gelen histopatolojik değişiklikler üzerinde morfin sulfatin etkisi]
    (Turkiye Klinikleri, 2017) Düzgün N.; Esme H.; Karabağli P.; İyisoy M.S.; Duran M.
    Objective: Endogenous opioids play an important role in tolerance to ischaemia at cellular level. We aimed to investigate the effect of morphine sulphate on the histopathologic changes in the lung tissue after ischemia reperfusion injury. Material and Methods: Forty female Wistar Albino rats were used in the study. The subjects were divided into 4 groups. İschemia reperfusion (IR) group; thoracotomy was performed from the fifth left intercostal space and ischemia reperfusion injury was established. İschemia reperfusion and ischemic postconditioning (IRPC) group; thoracotomy, ischemia reperfusion and postcondutioning. IRPC3 and IRPC30 groups; in addition to IRPC group, 3 and 30 ?mol morphine sulphate were administered. In the histopathological examination of lung tissue, neutrophile count, congestion, interstitial edema, tissue damage, and VEGF (Vascular endothelial growth factor) and EGFR (Epidermal growth factor receptor) positively stained cells were evaluated semi quantitatively. Results: In the histopathological analysis there was a statistically significant difference between the IR with IRAK (P<0.01), IRAK3 (P<0.01), and IRAK30 (P<0.01) groups in terms of neutrophile count and congestion edema scores. There was a statistically significant difference between the IR with IRAK (P<0.01) and IRAK3 (P<0.01) groups and IRAK with IRAK30 (P<0.05) groups in terms of tissue damage score. Moreover there was a statistically significant difference between the IR and IRAK3 (P<0.01) and IRAK30 (P<0.01) groups in the histopathological analysis in terms of VEGF (+) and EGFR (+) staining cell scores. Conclusion: As a result, ischemic postconditioning and administration of morphine sulphate were applied in the ischemic reperfusion period and histopathologic evaluation was performed. It has been determined that administration of morphine sulphate in the prevention of ischemia reperfusion injury is a more effective method than ischemic postconditioning. © 2017 by Türkiye Klinikleri.
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    [Frontal sinus obliteration with pericranial-subgaleal flap]. [Perikraniyal-subgaleal flep ile frontal sinüs obliterasyonu.]
    (2010) Oztürk K.; Duran M.; Arba? H.; Keleş B.; Kara M.; Uyar Y.
    We evaluated the results of patients who underwent frontal sinus obliteration with vascularized pericranial-subgaleal flap. Charts of patients (7 males 1 female; mean age 40.5+/-17.1 years; range 9 to 61 years) who underwent frontal sinus obliteration with pericranial-subgaleal flap between June 2001 and January 2008 were retrospectively reviewed. Demographics, indications for frontal sinus obliteration, immediate and late postoperative complications were recorded. All patients were invited to the clinic and underwent control examinations and computed tomography. The indications for frontal sinus obliteration were fracture of frontal sinus anterior and posterior walls in four cases, frontal sinus mucoceles in two cases, mucopyoceles in one case and fracture of frontal sinus anterior wall in one case. Bicoronal incision was used in all patients and then they underwent frontal sinus obliteration with lateraly based pericranial-subgaleal flap. In the postoperative period rhinorrhea and meningitis, which lasted for two days, developed in one patient with fracture of frontal sinus anterior-posterior walls and hypoestesia developed in the frontal skin area in one patient with fracture of frontal sinus anterior wall. No complications were observed in the other cases. Pericranial-subgaleal flap is a well vascularized, close to surgical area, inexpensive, safe and effective tissue that can be used for frontal sinus obliteration.
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    Intralabyrinthine lipoma [İntralabirintin lipoma]
    (2012) Uyar Y.; Keleş B.; Paksoy Y.; Duran M.; Azimov A.
    A 26-year-old man was admitted to our clinic with approximately 8 years history of hearing loss on the right side. The pathological findings were not found in the neuro-otological examination. Severity sensorinoral hearing loss (SNHL) was determined on the pure tone audiometry. The magnetic resonance imaging (MRI) and computed tomography (CT) were shown that the lipomatous lesion involved right cochlea, semicircular canal and internal auditorium canal. Intralabyrinthine lipoma was diagnosed via fat suppression techniques with MRI on T1-weighted images. The patient followed with MRI because he had just SNHL and the lesion minimal involved internal auditory canal.