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Öğe Akne vulgarisin anksiyete ve depresyon üzerine etkisi(Selçuk Üniversitesi Tıp Fakültesi, 2003) Dursun, Recep; Balevi, ŞükrüÇalışmada amaç, akne vulgarism anksiyete ve depresyon üzerine olan etkisini araştırmaktı. Yaşlan 14-30 arasında değişen (ortalama 20.81), adolesan ve genç erişkin dönemi, en az ilkokul mezunu, özgeçmişinde psikiyatrik tedavi öyküsü olmayan ve son onbeş gündür psikotrop ilaç kullanmayan, akne tedavisi almamış 63 kadın, 37 erkek olmak üzere 100 akne vulgarisli hasta ve 19 kadın, 9 erkek toplam 28 aknesi olmayan kontrol grubu çalışmaya alındı. Akneli hastaların akne şiddetleri, Global Akne Sınıfla ma Sistemine (GAGS) ne göre sınıflandı. Hastalara ve kontrol grubuna Hastane Anksiyete ve Depresyon (HAD) testi yapıldı. Hastalar 6 ay boyunca her ay kontrole gelmek üzere tedaviye alındı. 6 ay sonunda hastalara ve kontrol grubuna tekrar HAD testi uygulanarak tedavi öncesi ve sonrası hastalardaki anksiyete ve depresyon durumu kontrol grubuna göre karşılaştırıldı. Akneli hastalarda anksiyete ve depresyon tedavi sonrası kontrol grubuna göre anlamlı derecede azaldı. Hastaların anksiyete ve depresyonları ile akne şiddetleri arasında korelasyon yoktu. Akneli kadın hastalarda anksiyete, erkek hastalara göre daha şiddetli idi. Depresyon, tedavi öncesi erkek ve kadın hastalarda aynı oranlarda görülür ken, tedavi sonrası kadm hastalarda anlamlı olarak azaldı. Erkek hastalarda ise bir değişiklik görülmedi. Sonuç olarak, akne vulgarism adolesan ve genç erişkin dönemindeki erkek ve kadınların anksiyeteleri üzerine olumsuz etkisi görülmüştür (sırasıyla P=0.001 ve P=0.0005). Akne vulgarism, kadınların depresyonlarına olumsuz etkisi görülürken (P=0.002), erkeklerin depresyonları üzerine bir etkisi tespit edilememiştir (P=0.055). Akne vulgaris, kadm hastaların anksiyetelerini erkek hastalara göre daha çok şiddetlendirmektedir. Akneli hastaların tedavisi düzenli olarak yapılmalı ve hastanın akne karşısındaki psikososyal durumu dikkatle takip edilmelidir.Öğe Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Beh double dagger et's disease with or without ocular involvement(SPRINGER BASEL AG, 2009) Dursun, Ahmet; Durakbasi-Dursun, Hatice Gul; Dursun, Recep; Baris, Savas; Akduman, LeventThe association of known ACE gene and eNOS gene polymorphisms with BD in a group of Turkish patients with or without ocular involvement has been investigated. The ACE and eNOS gene polymorphisms were investigated in 73 BD patients and 90 controls. The distrubition of "DD", "ID" and "II" genotypes of the ACE gene were 32 (43.8%), 29 (39.8%) and 12 (16.4%) for BD patients and 32 (35.5%), 35 (38.9%) and 23 (25.6%) for healthy controls. There was no significant difference between the groups (p = 0.140, OR 1.44, CI 0.90-2.30). When Beh double dagger et patients with ocular involvement were compared to the control group, statistical significance was found (p = 0.049, OR 2.18, CI 1.00-4.81). The "bb", "ba", and "aa" genotype frequencies of the eNOS gene were 48 (65.8%), 23 (31.5%), and 2 (2.7%) for patients with BD and 75 (83.3%), 15 (16.7%), and 0 (0%) for healthy controls, respectively. The significant difference found in allelic frequencies between the two groups (p = 0.011, OR 2.32, CI 1.11-4.87). When Beh double dagger et patients with ocular involvement were compared, sharper statistical significance was found (p = 0.001,OR 4.61,CI 1.85-11.52). The ACE gene polymorphism does not play a role in the pathogenesis of BD. The findings of the eNOS gene polymorphisms confirmed the significant association with BD and even more in patients with ocular involvement.Öğe DETERMINATION OF DEFENSIN HNP-1 IN HUMAN SALIVA OF PATIENTS WITH ORAL MUCOSAL DISEASES(TAYLOR & FRANCIS INC, 2011) Kucukkolbasi, Hasan; Kucukkolbasi, Semahat; Dursun, Recep; Ayyildiz, Filiz; Kara, HuseyinSaliva is a biological fluid that is easily obtainable and that can give useful information both in systemic and oral diseases. In this study, a chromatographic method was applied to determine the amount of defensin HNP-1 in human saliva of patients with oral mucosal diseases before and after treatments and compared with controls. Defensin human neutrophil peptide-1 (HNP-1) was identified and confirmed. The concentration of HNP-1 in saliva was determined by comparing the area of eluted HNP-1 with that of HNP-1 standard. Linear calibration range of defensin HNP-1 was 0.10 to 0.90 mu g/10 mu L with R(2) values of 0.996. The concentrations of HNP-1 in the saliva of patients with oral lichen planus, Behcet's disease, and recurrent apthous stomatitis were 33.6 +/- 10.6, 15.5 +/- 7.6, and 36.3 +/- 9.5 mu gmL(-1) (mean +/- S.D.), respectively. The salivary defensin-1 concentration was significantly higher in patients with oral mucosal diseases than in healthy volunteers; furthermore, in patients with oral mucosal diseases, the concentration was significantly higher before treatment than after treatment.Öğe Genetic analysis of MEFV gene pyrin domain in patients with Behcet's disease(HINDAWI LTD, 2006) Dursun, Ahmet; Durakbasi-Dursun, Hatice Gul; Zamani, Ayse Gul; Gulbahar, Zerrin Gulin; Dursun, Recep; Yakicier, CengizObjectives. Behcet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. Methods. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing. Results. Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient. Conclusion. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction between pyrin domains are needed to be further investigated. Copyright (c) 2006 Ahmet Dursun et al.Öğe MMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitis(PERGAMON-ELSEVIER SCIENCE LTD, 2013) Ertugrul, Abdullah Seckin; Dursun, Recep; Dundar, Niyazi; Avunduk, Mustafa Cihat; Hakki, Sema SezginObjective: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown aetiology. The aim of this study was to investigate matrix metalloproteinase (MMP)-1, MMP-9, and MMP inhibitor-1 (TIMP-1) levels in gingival crevicular fluid (GCF) by enzyme-linked immunosorbent assay and to investigate MMP-1, MMP-9, and TIMP-1 levels in gingival tissue by immunohistochemical staining of samples from patients with and without OLP. Design: Twenty-seven patients with OLP (gingivitis, OLPG; chronic periodontitis, OLPP) and thirty healthy non-OLP patients (gingivitis, HG; chronic periodontitis, HP) were included in this study. The MMP-1, MMP-9, and TIMP-1 levels in GCF were determined by enzyme-linked immunosorbent assay. The MMP-1, MMP-9, and TIMP-1 levels in gingival tissue were determined by immunohistochemical staining. Results: The mean levels of MMP-1 and MMP-9 in the GCF of OLPP patients were significantly higher and TIMP-1 was significantly lower than in HP patients; similarly, the mean levels of MMP-1 and MMP-9 were higher and TIMP-1 was significantly lower in OLPG patients than in HG patients. Our findings illustrate that tissue MMP-9 levels were statistically higher and TIMP-1 level were significantly lower in the OLPP group in comparison to the HP group, and the OLPG group in comparison to the HG group. The tissue MMP-1 level in the non-OLP group was found to be lower when compared with the OLP groups. But not statistically significant. Conclusions: Increased levels of MMP-1 and MMP-9 with decreased levels of TIMP-1 in GCF and increased MMP-1, MMP-9 levels and decreased TIMP-1 levels in the gingival tissue of OLP patients in combination with poor oral hygiene may cause increased tissue breakdown. The results of our study provide information about the effects of the periodontal status on the enzyme profiles in GCF and gingival tissue of OLP and non-OLP patients. (C) 2013 Elsevier Ltd. All rights reserved.Öğe Papillon LeFèvre Sendromlu Hastalarda Alveoler Soket Koruma Yöntemi Olarak İmplant Yerleştirilmesi; İki Olgu Sunumu(Selçuk Üniversitesi, 2021) İnönü, Elif; Dursun, Recep; Hakkı, Sema S.; Mutafcılar, Emine ElifPapillon-Lefèvre sendromu, süt ve daimî dentisyonda erken diş kaybı ve palmaplantar hiperkeratoz ile karakterize otozomal resesif geçişli genetik bir hastalıktır. Bu olgu raporunda, PapillonLefèvre sendromlu (PLS) iki hastada, alveolar kemiği korumak için diş köklerinin diş eti altında bırakılması ve çekimlerini takiben çekim soketinin implant ile korunması sunuldu. PLS tanısı konmuş 18 yaşında erkek ve 29 yaşında kadın hasta Selçuk Üniversitesi Periodontoloji Anabilim Dalı kliniğinde 11-12 yaşlarından itibaren takip edilerek periodontal tedavi ile dişlerin ağızda tutulmasına çalışılmıştır. Şiddetli mobilitesi olan dişler çekildikten sonra birçok kez protezleri yenilenmiştir. 43 ve 33 nolu diş köklerinin diş eti altında bırakılmasının ardından kökler yaklaşık 5 yıl boyunca ağızda tutulabilmiştir. Dişlerin ağız ortamına açıldıktan sonra kaybedilmesinin ardından alveolar kemiğin korunması amacıyla aynı bölgelere dental implant yerleştirilerek alveolar kemik rezorpsiyonu riski nedeniyle diş eti altında bırakılmıştır. Klinik ve radyografik olarak kontrol edilen hastalarda yumuşak doku komplikasyonu gözlenmeksizin ve dişsiz sahalara kıyasla kemik seviyesi korunabilmiştir.Öğe Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis(NATURE PUBLISHING GROUP, 2013) Ertugrul, Abdullah Seckin; Arslan, Ugur; Dursun, Recep; Hakki, Sema SezginOral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-I Dent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP.Öğe Psychiatric disorders in patients with Behget's disease(TAYLOR & FRANCIS LTD, 2007) Dursun, Recep; Uguz, Faruk; Kaya, Nazmiye; Cilli, Ali Savas; Endogru, HuseyinObjective. In this study, we aimed to investigate current prevalence and related clinical factors of psychiatric disorders in Behcet patients. Methods. Seventy-three outpatients who applied to a Behcet clinic and whose diagnosis was Behcet's disease according to criteria of the International Study Group for Behcet's disease were recruited in this study. Psychiatric diagnoses were assessed with The Structured Clinical Interview for DSM-IV/Clinical Version (SCID-I/CV). Results. Thirty patients (41.1%) reported at least one current psychiatric disorder. Major depression (17.8%) was the most frequent psychiatric disorder. Specific phobia (16.4%), generalized anxiety disorder (15.1%) and social phobia (9.6%) were other frequent disorders. Prevalence rates of any psychiatric and anxiety disorder were significantly higher in females than males. There was no significant relationship between psychiatric morbidity and clinical characteristics of Behcet's disease. Conclusion. Our study suggests that Behcet patients have high prevalence of psychiatric disorders. Therefore, psychiatric evaluation should be performed in all patients with Behcet's disease.Öğe Quality of life in patients with Behcet's disease: the impact of major depression(ELSEVIER SCIENCE INC, 2007) Uguz, Faruk; Dursun, Recep; Kaya, Nazmiye; Cilli, Ali SavasObjective: Behcet's disease (BD) is a multisystemic inflammatory disorder associated with high levels of depressive symptoms and lower quality of life (QoL). In this study, we aimed to investigate the impact of major depression (MD) on the QoL of patients with BD. Method: BD outpatients (n = 25) and psychiatric outpatients (n = 25) with only MD among the Axis I psychiatric disorders, and BD outpatients (n = 25) and healthy controls (n = 25) without any Axis I psychiatric disorder were included in the study. The Structured Clinical Interview for DSM-IV (SCID-I) was used to determine Axis I psychiatric disorders. Depression and QoL levels were assessed with the Beck Depression Inventory (BDI) and the World Health Organization QoL Assessment-Brief (WHOQOL-BREF), respectively. Results: There was no significant difference with regard to demographic characteristics between the groups. Psychiatric and BD patients with MD had significantly lower overall WHOQOL-BREF subscale scores than BD patients without MD and healthy controls. No significant difference was found in terms of QoL between the groups of psychiatric and BD patients with MD, nor between the groups of BD patients without MD and healthy controls. Overall, there was a significantly negative correlation between all WHOQOL-BREF subscale and BDI scores in BD patients. Conclusion: The study suggests that concurrent MD has a negative impact on QoL of BD patients and that QoL is negatively correlated with the severity of depressive symptoms. (c) 2007 Elsevier Inc. All rights reserved.
