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    Evaluation of h?D-1 and h?D-2 levels in saliva of patients with oral mucosal diseases
    (University of the West Indies, 2013) Kucukkolbasi H.; Kucukkolbasi S.; Ayyildiz H.F.; Dursun R.; Kara H.
    Objective: This study aimed to determine a possible correlation between oral mucosal disease and salivary concentrations of the antimicrobial peptides human beta-defensin-1 (h?D-1) and human betadefensin- 2 (h?D-2). Method: The present work focussed on the establishment of a reversed phase-high performance liquid chromatography (RP-HPLC) procedure to quantify human beta-defensins (h?D-1 and h?D-2) in saliva samples of patients with oral diseases such as lichen planus (n = 10), Behçet (n = 10) and recurrent apthous stomatitis (n = 10). Results: Linear calibration range for h?D-1 and h?D-2 defensins was 1.67-200 ?g mL-1 and 3.13 - 100 ?g mL-1 with R2 values of 0.9998 and 0.996, correspondingly. The concentration of beta-defensins in saliva was determined by comparing the peak areas of eluted h?D-1 and h?D-2 with that of their standards. The variation of the amount of beta-defensins was evaluated by comparisons of the results obtained from the patients with oral mucosal diseases before and after treatments and the control subjects. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.62 ?g mL-1 and 5.39 ?g mL-1 for h?D-1 and 0.94 ?g mL-1 and 3.13 ?g mL-1 for h?D-2, respectively. Conclusion: The salivary beta-defensin concentration was significantly higher in patients with oral mucosal diseases than in healthy volunteers; furthermore, in patients with oral mucosal diseases, the concentration was significantly higher before treatment than after treatment.
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    Psychiatric symptoms and quality of life in Behçet patients [Behçet hastalarinda ruhsal belirtiler ve yaşam kalitesi]
    (2006) U?uz F.; Dursun R.; Kaya N.; Çili A.S.
    Objective: The aim of this study was to investigate psychiatric symptoms, quality of life, and the factors associated with quality of life in patients with Behçet disease. Methods: The study sample was formed by consecutive 73 Behçet patients who admitted to a Behçet outpatient clinic of a university hospital, and 34 healthy subjects matched for age, gender, educational level, and marital status. The patients and control groups were assessed with Symptom Check List-90-Revised Version (SCL-90-R), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Quality of Life Index (WHOQOL-Brief). Results: There were no significant differences between patient and control groups with respect to gender, age, educational level and marital status. BDI, BAI and all subscale scores of SCL-90-R were significantly higher and physical and psychological health subscale scores of WHOQOL-Brief were significantly lower in Behçet patients compared to controls. No significant difference was found between the groups for social relationships and environment domains of quality of life. Female patients had lower physical health subscale scores of WHOQOL-Brief compared to male patients. A negative correlation was found between levels of psychiatric symptoms and all quality of life domains. Conclusion: The present study suggests that when compared with healthy subjects, Behçet patients have higher level of psychiatric symptoms, and they have lower level of quality of life in physical and psychological health domains. Psychiatric symptoms negatively influence the quality of life in Behçet patients. Therefore, psychiatric evaluation should be performed for all Behçet patients.