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    Kikuchi-fujimoto disease in a patient with mediastinal lymphadenopathy
    (2014) Turan, Hale; Şerefhanoğlu, Kıvanç; Apilioğulları, Burhan; Arıbaş, Olgun Kadir; Ekici, Zuhal; Timurkaynak, Funda; Arslan, Hande
    Kikuchi-Fujimoto disease is a benign self-limited syndrome with distinct histopathologic characteristics. Clinical symptoms include cervical lymphadenopathy with tenderness, fever of medium grade, night sweats, nausea, vomiting, and a sore throat. It is a rare disease worldwide. Diagnosis is based on histopathologic fndings from an excisional lymph node biopsy. We present the case of a 37-year-old male patient with a fever of 15 days duration. Clinical examination revealed no other pathologic signs except for oral aphthous lesions and a fever of unknown origin. The patients fever did not resolve after 15 days follow-up, and the results of computed tomographic study of the thorax revealed several sites of mediastinal lymphadenopathy. The diagnosis of Kikuchi-Fujimoto disease (histiocytic necrotising lymphadenitis) was based on the results of pathologic examination of the biopsy specimen. The patients signs and symptoms resolved without antibiotic therapy. This case report of a patient with a fever of unknown origin is presented because of the rare involvement of mediastinal lymphadenopathy without cervical lymphadenopathy. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of the patient who presents with fever and mediastinal lymphadenopathy.