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Öğe Arterial Stiffness and Carotid Intima-Media Thickness in Diabetic Peripheral Neuropathy(INT SCIENTIFIC LITERATURE, INC, 2014) Avci, Ahmet; Demir, Kenan; Kaya, Zeynettin; Marakoglu, Kamile; Ceylan, Esra; Ekmekci, Ahmet Hakan; Yilmaz, AhmetBackground: We investigated the relationship between peripheral neuropathy and parameters of arterial stiffness and carotid intima media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Material/Methods: The study included 161 patients (80 females and 81 males), 69 of whom had peripheral neuropathy. All patients underwent 24-h blood pressure monitoring, and arterial stiffness parameters were measured. The CIMT was measured using B- mode ultrasonography and patients also underwent transthoracic echocardiographic examination. Results: Patients with peripheral neuropathy, compared with those without it, were older (54.68 +/- 8.35 years vs. 51.04 +/- 7.89 years; p= 0.005) and had T2DM for longer periods (60 vs. 36 months; p= 0.004). Glycated hemoglobin (HbA1c) values (8.55 +/- 1.85 mg/dL vs. 7.30 +/- 1.51 mg/dL; p<0.001), pulse wave velocity (PWV) (7.74 +/- 1.14 m/s vs. 7.15 +/- 1.10 m/s; p= 0.001), CIMT (anterior 0.74 +/- 0.15 mm vs. 0.67 +/- 0.13 mm; p= 0.01), and left ventricular mass (LVM) index (98.68 +/- 26.28 g/m(2) vs. 89.71 +/- 19.70 g/m(2); p= 0.02) were all significantly increased in the group with peripheral neuropathy compared to the group without peripheral neuropathy. We determined that duration of diabetes, HbA1c, and LVM index were predictors of peripheral neuropathy. Conclusions: A significant relationship was found between diabetic neuropathy and increased PWV, a parameter of arterial stiffness, as well as CIMT, a marker of systemic atherosclerosis. Diabetic peripheral neuropathy may be a determinant of subclinical atherosclerosis in T2DM.Öğe Atlas-Based Segmentation Pipelines on 3D Brain MR Images: A Preliminary Study(EDUSOFT PUBLISHING, 2018) Ozic, Muhammet Usame; Ekmekci, Ahmet Hakan; Ozsen, SeralThree dimensional structural MR imaging is a high-resolution imaging technique used in the detection and follow up of neurological disorders. Rigid changes in the brain are usually interpreted and reported manually by radiologists using MR images. The results of manual interpretation may vary with respect to the experts. At the same time, measurement and segmentation of the brain regions and the manual evaluation of the volume changes are a difficult process. With the increase of numerical methods, automated and semi-automated package programs have been developed for the analysis of brain measurements. These programs use electronic brain atlases or tissue probability maps. However, since the package programs have a lot of analysis time and give only certain outputs, they may be disadvantaged in the use of segmentation and measurement of brain regions. Hence, special pipelines are needed especially to obtain valuable features for artificial intelligence and classification studies. In this study, we propose pipelines to segment 3D certain brain regions, which will help to find the basic features such as volume changes, intensity variations, symmetry deteriorations, and tissue changes. With these pipelines, 3D segmentation of the brain regions defined in the atlas can be performed and normalized. It is aimed to use these studies as a preliminary study in order to quantitatively determine the basic changes in the brain by performing the volume of interest methods and to formulate a decision support system.Öğe Classification of Dementia with ANN using Multiple Variable(IEEE, 2015) Ozic, Muhammet Usame; Ozbay, Yuksel; Ekmekci, Ahmet HakanDementia is a stage that identifies all of the symptoms that led to the weakening of multiple cognitive functions. It is usually expressed as "bunama" among people. Dementia is not a disease itself is known as a transition period that defines the initial stages of many diseases. Proportional change in mental function of many variables that influence causes our body causing this stage, textural and volume losses which may occur in the brain, the person may be counted as demographic and clinical variables. Prediction of disease with a combination of variables is one of the popular sizes in recent topics in the literature. In this study received the demented patients from Open Access Series of Imaging Studies (OASIS) database structural magnetic resonance (MR) imaging features and use in combination with the demographic data of the patients was investigated in artificial neural networks classification performance.Öğe The Evaluation of the Muscle Fatigue Using Frequency Features in the Cervical Region(IEEE, 2014) Ozmen, Guzin; Ozbay, Yuksel; Ekmekci, Ahmet HakanSurface electromyography is a method which is for the evaluation of the electrical activity of superficial muscles. Moreover, muscle fatigue can also be detected using surface electromyography. In this study, on 20 volunteers, the muscle fatigue in cervical region was examined using surface electromyogram signals obtained from the trapezius and sternocleidomastoid muscle. Median frequency, mean frequency and mode frequency values were calculated by Welch method to investigate the muscle fatigue. When the Trapezius and sternocleidomastoid muscles are gone from study status to fatigue status the frequency parameters have shifted towards low frequencies. In practice, the median and mean frequency values are reliable parameters for muscle fatigue. According to the results; while the muscle fatigue was observed in 27 records for the median frequency, it was occurred in 22 records for the average frequency.Öğe Headache-like Subarachnoid Hemorrhage After Digital Subtraction Angiography: A Case Report(TURKISH NEUROLOGICAL SOC, 2018) Eren, Fettah; Ekmekci, Ahmet Hakan; Karabagli, Hakan; Ozturk, SerefnurSubarachnoid hemorrhage (SAH) is a clinical condition with acute-onset, sudden, and severe headache. In addition to headache, severe nausea, vomiting, dizziness, confusion, agitation, focal neurologic deficits, and hypertension can be detected. Findings of meningeal irritation may accompany to these clinical features, 6-24 hours after the hemorrhage. Digital subtraction angiography (DSA) is used for surgical or endovascular treatment planning in order to identify vascular abnormalities, in addition to other imaging studies. After DSA, the frequency of all neurologic complications is between 0.2% and 4.5%. Headache may occur after DSA in an average 50% of patients. This rate is especially higher in female patients. Headache types are usually classified as migraine, tension or postoperative atypical headaches The incidence of severe headache after DSA is low. Vascular wall rupture should be considered first in severe headache after the procedure. It should also be kept in mind that after all other secondary causes are excluded; SAH-like headaches after DSA can be detected.Öğe Kistikintraserebral Görüntüleme Örneği ile Başvuran Multiple Skleroz Hastalığı(Selçuk Üniversitesi, 2018 Mart) Eren, Fettah; Öngün, Gözde; Gezer, Aslıhan; Ekmekci, Ahmet Hakan; Öztürk, ŞerefnurMultipl skleroz (MS) tanısında ve ayırıcı tanısında bazı olgularda çeşitli güçlükler yaşanmaktadır. Klinik belirti ve bulgular yanında, manyetik rezonans görüntüleme (MRG), beyin omurilik sıvısı (BOS) incelemesi ve uyarılmış potansiyeller tanıyı kesinleştirmek için önemlidir. Tüm bunlara rağmen bu testlerin tanısal duyarlılık ve özgüllüğü sınırlıdır. Elli yedi yaşında tavuk çiftliği işletmecisi olan erkek hasta, 35 gün önce başlayan sağ yüz yarısında uyuşma ve denge bozukluğu yakınması ile başvurdu. Sağ yüz yarısında objektif hipoestezi ve sağda Babinski bulgusu saptandı. Beyin MRG incelemesindeki; 2 cm çapında, halkasal kontrast tutulumu olan homojen lezyon öncelikle kistik bir oluşumu düşündürdü. BOS ve görsel uyarılmış potansiyel neticesinde hastanın MS olduğu anlaşıldı. Bu hastaların klinik ve nörogörüntüleme ile takibi ayırıcı tanıda değerli bilgiler sağlayabilmektedir.Öğe Lentiform Fork Sign: Neuroradiologic Features and Differential Diagnosis(TURKISH NEUROLOGICAL SOC, 2018) Eren, Fettah; Ekmekci, Ahmet Hakan; Ozturk, Serefnur[Abstract not Available]Öğe Neurosyphilis Presenting with Ptosis and Diplopia as the First Complaints: Case Report(TURKISH NEUROLOGICAL SOC, 2018) Eren, Fettah; Aygul, Recep; Ekmekci, Ahmet Hakan; Ozturk, SerefnurSyphilis is a spirochete disease that occurs due to Treponema pallidum infection. It can be sexually transmitted and can be transmitted from mother to baby vertically. Neurological involvement is more common in the late period. The use of common antibiotics may alter the natural course of the disease. Because of this, syphilis may present with different neurological findings. A 49-year-old male patient was admitted to our clinic with complaints of fluctuating double vision and droopy left eyelid for two months. In the neurological examination, pupils were mid-dilated, direct and indirect pupillary light reflexes were bilaterally absent, movements of the left eye in all directions and rightward movement of the right eye were restricted. Also, bilateral ptosis was detected. Brain magnetic resonance imaging and electrophysiological studies including repetitive stimulation were normal. Syphilis was diagnosed with blood and cerebrospinal fluid (CSF) tests. He was treated with long-term high-dose intravenous penicillin. Ocular findings are an important indicator of neurosyphilis. Ocular involvement due to primary disease process is rare. If meningitis-related CSF absorption defect develops, eye movement disorders and pupil abnormalities may occur. The diagnosis of neurosyphilis may be delayed due to different clinical manifestations. Neurosyphilis should be considered in case of ocular findings.Öğe A Novel Feature Extraction Approach with VBM 3D ROI Masks on MRI(SPRINGER-VERLAG SINGAPORE PTE LTD, 2017) Ozic, Muhammet Usame; Ozsen, Seral; Ekmekci, Ahmet HakanAlzheimer's disease is a neurological disorder that usually starts with aging. Alzheimer's disease is a serious health and economic burden on governments, along with an increase in elderly population in developed and developing countries. There is no known cause of this disease and there is no treatment. For this reason, early diagnosis of the disease, socioeconomic and psychological outputs and medical treatments are still a hot topic investigated in the world. Magnetic Resonance Imaging is one of the medical imaging techniques that show the progression of Alzhiemer in brain. Brain deterioration and volume loss of the disease first begins with memory regions and then spreads to other brain regions. If atrophy is observed and detected by manual methods, it may not be seen due to user dependency, operator error and inexperience. For these reasons, automatic, numerical and atlas-based methods are being developed for the observation and capture of neurological diseases. In this study, 99 Alzheimer patients and 99 normal control MR images were analyzed using Voxel Based Morphometry, one of the numerical methods of atrophy observations in Magnetic Resonance Imaging. Losses in the brain were then produced as three-dimensional binary masks. Using these masks, normalized segmented, modulated normalized segmented, and normalized images that were stripped from the non-brain structures were masked. Histogram based first order statistical features were extracted in the masked areas. The efficany of this technique was statistically compared between Alzheimer's and normal control. MR images have been downloaded freely from the OASIS database.Öğe Saf Duyusal İnme Sendromu Şeklinde Ortaya Çıkan Talamik Bölge Serebrovasküler Hastalığı: Olgu Sunumu(Selçuk Üniversitesi, 2017 Eylül) Eren, Fettah; Öztürk, Şerefnur; Ekmekci, Ahmet HakanSaf duyusal inme, derin ya da yüzeyel duyuların ayrı ayrı veya beraber tutulduğu, duysal veya irritatif bozukluklar ile kendini gösteren klinik sendromdur. Bu sendromda en sık talamusun ventro-posterior nükleusu etkilenir. Talamik etkilenmeleri olan hastalarda yukarı bakış felci, hemiparezi, hemihipoestezi, konfüzyon, uykuya meyil, duygusal labilite olabilmektedir. Talamus tüm duyu modalitelerinin (koku hariç) ortak kesişim noktası olduğundan tat, işitme, dokunma ve ağrı gibi duyusal modaliteler saf duyusal inmelerde etkilenebilmektedir. 56 yaşında erkek hasta sol kol, bacak, yüz ve gövde yarısında uyuşma yakınması ile başvurdu. Manyetik rezonans görüntülemede sağ talamusta iskemi ile uyumlu lezyon belirlendi. Sonrasında santral nörojenik ağrı sendromu gelişti. Nadir görülmesi, ek belirti olmadan hemihipoestezi ile başvurabilmesi ve hızla tanınıp tedavi başlanması gerektiğinden sunulmaya değerli görülmüştür.Öğe Voxel Based Morphometric Analysis on MR Images(IEEE, 2017) Ozic, Muhammet Usame; Ozsen, Seral; Ekmekci, Ahmet HakanExamining of progress of diseases that occur in brain using numerical methods is one of the topics of neuroscience researches. One of the developing numerical methods for examinig local and global changes that occur in brain is Voxel Based Morphometry. For examining intragroup and intergroup differences via Voxel Based Morphometry is required to use some preprocessing methods together with statistical tools. In this study, Voxel Based Morphometry method have been examined using labeled Normal Control and Alzheimer Disease. Magnetic Resonanse images were taken from Open Access Series of Imaging Studies database. After examining volumetric differences as statistical that occur in the brain between two groups via Voxel Based Morphometry, it has been mapped on the template atlases.
