Yazar "Ela, Yuksel" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The effect of dexmedetomidine in the prefrontal cortex of rabbits after subarachnoidal hemorrhage
    (UNIVERSITATSVERLAG ULM GMBH, 2006) Eser, Olcay; Cosar, Murat; Fidan, Huseyin; Sahin, Onder; BuyukbaS, Sadik; Ela, Yuksel; Songur, Ahmet
    Background: This study was undertaken to examine the possible neuroprotective effect of dexmedetomidine in the prefrontal cortex of vasospastic subarachnoid hemorrhage (SAH) rabbits. Materials and Methods: Experimental SAH was performed to the 12 of 18 New Zealand rabbits by injecting 0.9 ml of autologous arterial blood/1 kg of body weight to cisterna magna. Craniotomy procedure was performed to the rest 6 rabbits (control group) (Group A) except performing experimental SAH. Forty eight hours after SAH was established, 5 mL/kg/hour 0.9% sodium chloride were infused to the SAH-alone group (n=6) (Group B) and 5 mu g/kg/h dexmedetomidine were infused to the SAH-dexmedetomidine group (n=6) (Group C) for 2 hours. Rabbits of all groups were sacrificed via penthotal after 24 hours following this drug administration processes. Brains were removed from the skull totally, prefrontal cortices were blocked from the right hemisphere for histopathological study, and prefrontal cortex of left hemispheres were dissected for biochemical analyses. So, malondialdehyde levels, activities of xantine oxidase, and superoxide dismutase were studied from the left prefrontal cortex. Results: The histopathological results showed that dexmedetomidine has neuroprotective effect in SAH induced prefrontal cortex injuries. The antioxidant parameters also supported the neuroprotective effect of dexmedetomidine. Conclusion: The present study showed the neuroprotective effect of dexmedetomidine in the prefrontal cortex of rabbits after vasospastic subarachnoid hemorrhage.
  • Küçük Resim Yok
    Öğe
    The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage
    (ELSEVIER SCIENCE INC, 2009) Cosar, Murat; Eser, Olcay; Fidan, Huseyin; Sahin, Onder; Buyukbas, Sadik; Ela, Yuksel; Yagmurca, Murat
    Background: Subarachnoid hemorrhage is a Serious Condition. often accompanied by cerebral vasospasm. which may lead to brain ischemia and neurologic deterioration. We evaluated if dexmedetomidine has neuroprotective effects in the hippocampus of vasospastic SAH rabbits or not. Materials and Methods: Eighteen New Zealand rabbits were taken. Ail experimental SAH model was Formed by injecting 0.9 mL of autologous arterial blood per 1 kg of body weight to the cisterna magna of 12 rabbits. Craniotomy was performed ill the control group (n = 6) except performing experimental SAH. Rabbits in the SAH-alone (n = 6) group were infused with 5 mL . kg(-1) . h(-1) 0.9% sodium chloride, and rabbits (n = 6) in the SAH-dexmedetomidine group were infused with 5 mu g . kg(-1) . h(-1) dexmedetomidine for 2 hours, 48 hours alter SAH was established. Rabbits of all groups were sacrificed via penthotal 24 hours after dexmedetomidine administration. Brains were removed immediately. and hippocampal tissues were blocked from the right hemisphere for histopathologic study. In addition to this, hippocampal tissues of left hemispheres were dissected for biochemical analyses to evaluate MDA levels, activity of XO, and SOD. Results: The histopathologic study showed that dexmedetomidine may have a neuroprotective effect in SAH-induced hippocampal injuries. The biochemical parameters Support the neuroprotective effect of dexmedetomidine (P < .05). Conclusion: Our Study showed that dexmedetomidine may have a neuroprotective effect ill the hippocampus of vasospastic SAH rabbits. (C) 2009 Elsevier Inc. All rights reserved.