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    DiGeorge Syndrome with Sacral Myelomeningocele and Epilepsy
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2017) Alkan, Gülsüm; Emiroğlu, Melike Keser; Kartal, Ayşe
    DiGeorge syndrome (DGS) is the most common microdeletion syndrome. The phenotype of DGS is highly variable involving facial, velopharyngeal, cardiac, immunologic, endocrinal, and neuropsychiatric abnormalities. Although neural tube defects (NTDs) have not been described as components of DGS in standard pediatric textbooks, there have been a few case reports of DGS with NTDs. Furthermore, in patients with DGS, seizures can occur due to hypocalcemia or cortical dysgenesis. Few cases of epilepsy have been reported with NTDs without a cortical defect. Here, we report a case of an infant with DGS with a sacral myelomeningocele inherited from the mother. The infant developed epilepsy without hypocalcemia or cortical dysgenesis which is considered related to the sacral myelomeningocele.
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    Severe pertussis pneumonia in an infant: Treated with exchange transfusion: Case report
    (OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2017) Alkan, Gülsüm; Emiroğlu, Melike Keser
    Pertussis, becomes serious when refractory hypoxemia develops from hyperleukocytosis and pulmonary hypertension, especially in infants. Here, we present the case of a 2 monthsold infant with severe pertussis pneumonia and hyperleukocytosis. A double volume exchange transfusion (ET) was needed for cardiopulmonary insufficiency unresponsive to intensive care. Oxygenation gradually improved within 48 hours after the treatment. A high white blood cell count can be a predictor of death in infants with pertussis. We considered that clinical improvement was observed due to a reduction cluster of leukocytes and also toxins, because of pertussis is a toxin-releasing infection. The early use of ET may prevent fatal outcomes in infants with severe pertussis, who failed to respond to standard therapy. Copyright © 2017 by Türkiye Klinikleri.
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    Surveillance of penicillin resistance of Neisseria meningitidis strains from invasive infections between 2013 and 2018 in Turkey
    (TAYLOR & FRANCIS LTD, 2020) Öncel, Eda Karadağ; Ceyhan, Mehmet; Başaranoğlu, Sevgen Tanır; Gürbüz, Venhar; Aycan, Ahmet Emre; Özsürekci, Yasemin; Kurugöl, Zafer; Emiroğlu, Melike Keser; Devrim, İlker; Karbuz, Adem; Akışoğlu, Havva Özlem Altay; Gürler, Nezahat
    Neisseria meningitidis (N. meningitidis) is regarded as the leading cause of bacterial meningitis in many regions of the world. The empiric antimicrobial treatment is mainly based on antimicrobial resistance and patient characteristics. We aimed to analyze susceptibility patterns of N. meningitidis strains isolated in Turkey. Invasive meningococci collected in a multicenter, hospital-based, epidemiological surveillance study of pediatric (0-18 years of age) bacterial meningitis cases between 2013 and 2018 were studied. Five isolates (8.7%) displayed resistance to penicillin-G, while 13 isolates (22.8%) had intermediate susceptibility. All isolates were cefotaxime and rifampin susceptible. The data shows appropriateness of third-generation cephalosporins in empirical use for meningococcal infections in children. Since Turkey is located in a transition zone geographically, surveillance reports are very crucial.