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Öğe The effect of N-acetyl cysteine on serum glutathione, TNF-alpha and tissue malondialdehyde levels in the treatment of sepsis(TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2011) Gul, Mehmet; Ayan, Murat; Seydanoglu, Abdusselam; Cander, Basar; Girisgin, Sadik; Erayman, Ibrahim; Erdem, SamiBACKGROUND The aim of this study was to investigate the effects of N-acetyl cysteine (NAC) on the levels of reactive oxygen species in sepsis. METHODS In this study, 30 Sprague-Dawley female rats weighing 180-200 g were used. Rats were randomized into three groups, each containing 10 rats, as follows: Group I: Sham, Group II: Sepsis and Group III: Sepsis+NAC. Group I underwent only laparotomy. In Groups II and III, sepsis was induced by cecal ligation and perforation (CLP) technique. NAC (20 mg/kg/day) was administered orally to Group III at 0, 8 and 16 hours. At the 24th hour, tissue and blood samples were taken for erythrocyte glutathione (GSH) and serum tumor necrosis factor (TNF)-alpha levels, histopathological determination, and lung, liver and kidney tissue malondialdehyde (MDA) analyses. RESULTS Group III was significantly different from the other groups with respect to erythrocyte glutathione, serum TNF-alpha and kidney MDA levels (p<0.05). There was no significant difference between the groups regarding liver MDA levels and histopathological parameters for lung, liver and kidney (p>0.05). CONCLUSION NAC treatment had beneficial effects on erythrocyte GSH, serum TNF-alpha, lung function, and kidney MDA levels in sepsis-induced rats. However, this beneficial effect was not confirmed as histopathological improvement. Further research is needed to prove the effect of NAC in sepsis treatment.Öğe Primary spinal hydatid cyst in a patient with acquired immunodeficiency syndrome(SPRINGER, 2011) Erayman, Ibrahim; Kalkan, Erdal; Erdi, Fatih; Kerimoglu, Ulku; Esen, HasanSpinal hydatid cyst is a serious and unusual infectious disease. There is little information on infections caused by cestodes in patients with human immunodeficiency virus (HIV) infection. Although infrequent, infections by cestodes constitute a cause of disease in HIV-infected patients, especially in endemic areas. This report presents, for the first time in the literature, primary spinal cyst hydatid in a patient with acquired immunodeficiency syndrome.Öğe RISC FACTORS ASSOCIATED WITH IMIPENEM RESISTANCE IN NOSOCOMIAL ACINETOBACTER BAUMANNII INFECTIONS(NOBEL ILAC, 2012) Balci, Mehmet; Bitirgen, Mehmet; Kandemir, Bahar; Aribas, Emel Turk; Erayman, IbrahimObjective: This study was conducted to identify the risk factors associated with imipenem resistance in recently increase with frequency of nosocomial Acinetobacter baumannii infections. Material and Method: In the present study, strains of A. baumannii isolated from various clinical samples obtained from the patients followed at the Meram Faculty of Medicine Hospital of Selcuk University between September 2005 and March 2007 and whose samples were sent to the Department of Clinical Bacteriology and Infectious Disease laboratories were evaluated. Results: The imipenem resistance rate of the 79 patients who were evaluated was 54.5%; risc factors associated with imipenem resistance were determined according to the E-test method. Prolonged hospitalization, previous use of a third generation cephalosporin, carbapenem and glycopeptides, use of any antibiotic for longer than 21 days, presence of a central catheter, tracheostomy and/or intubation, mechanical ventilation, transfusion, administration of total parenteral nutrition, use of an antiacid, hemodialysis or hemofiltration and the presence of pneumonia were shown to be resistance-associated factors by using single variance analysis (p<0.05). Independent risk factors associated with imipenem resistance were determined to be the presence of a central catheter [odds ratio (OR) 4.34; 95% confidence interval (CI) 1.1-17.1; p=0.010], carbapenem use (OR 3.769; 95% CI 1.1-12.7; p=0.000), and period of hospitalization for longer than 21 days (OR 3.787; 95% CI 1.01-14.696; p=0.000) by using multiple variance analysis. Isolation of A. baumannii from the surgical site was associated with imipenem sensitivity (OR 0.176; 95% CI 0.45-0.684; p=0.05). Conclusion: The incidence of imipenem resistant A. baumannii infections increased during the last years especially in critical care units. Imipenem resistant Acinetobacter baumannii infections should be considered and required precautions must be taken in patients who had a history of the usage of central venous catheter and carbapenems and in patients with long hospital stay.Öğe Role of diffusion weighted MR in the discrimination diagnosis of the cystic and/or necrotic head and neck lesions(ELSEVIER IRELAND LTD, 2007) Koc, Osman; Paksoy, Yahya; Erayman, Ibrahim; Kivrak, Ali Sami; Arbag, HamdiPurpose: The purpose was to determine whether the diffusion weighted imaging (DWI) was able to differentiate necrotic tumor or metastatic lesions from infected necrotic lesions such as abscesses and necrotic lymphadenitis in the neck. Materials and methods: DWI was performed on 37 consecutive patients with 85 head and neck necrotic and cystic lesions. The lesions were classified into four categories: metastatic lymph node involvement including lymphoma, necrotic tumor, abscesses and necrotic lymphadenitis. Each lesion was histopathologically studied and proved. Results: In 12 patients, there were 35 necrotic lymphadenitis (necrotic tuberculosis lymphadenitis, n = 18; necrotic nonspecific suppurative lymphadenitis, n = 17). Of the 15 necrotic metastatic nodes, 11 lesions were lymphomatous involvement and 4 lesions were other tumor involvement. Other 11 patients have abscesses. Thirteen primary tumoral necrotic lesions arose in the neck of nine patients. All of the abscesses and necrotic lympadenitis showed hyperintensity on DWI, in contrast to necrotic tumor and necrotic nodal metastasis that showed hypointensity on DWI. DWI successfully differentiated metastatic nodes and necrotic tumors from necrotic lymphadenitis and abscesses. Conclusion: DWI may be supportive for differentiating necrotic tumor lesions such as necrotic tumor and metastatic necrotic nodes from the infective necrotic lesions such as necrotic lymphadenitis and abscesses in the head and neck. (c) 2006 Elsevier Ireland Ltd. All rights reserved.Öğe Tularemia presenting with tonsillopharyngitis and cervical lymphadenitis: Report of two cases(TAYLOR & FRANCIS AS, 2007) Kandemir, Bahar; Erayman, Ibrahim; Bitirgen, Mehmet; Aribas, Emel Turk; Guler, SelmaTularemia is a zoonotic disease caused by Francisella tularensis. Francisella tularensis is transmitted to humans by direct contact or ingestion of infected animal tissues, through the bite of infected arthropods, by consumption of contaminated food or water, or from inhalation of aerolized bacteria. In this report we describe 2 cases with oropharyngeal tularemia who presented with tonsillopharyngitis and cervical lymphadenitis.
