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Öğe Effect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosis(RIYADH ARMED FORCES HOSPITAL, 2007) Caglar, Sukru; Torun, Fuat; Erdemli, Esra; Torun, Ayse N.Objective: To investigate whether iloprost, a stable analog of prostacyclin, is useful for the preservation of neural grafts in transplantation surgery. Methods: This study was conducted at the Microsurgery Laboratory of the Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey in 2003. The animals (rabbits) were divided into 3 groups. In group I, autografts taken from the adrenal medulla were stored in 0.9% sodium chloride (NaCl) solution for 45 minutes before transplantation. In group II, autografts taken from the adrenal medulla were stored in iloprost solution (50 ng/ ml) for 45 minutes before transplantation. Graft transplantation was not performed in the third group. Results: In group 1, the grafts partially preserved their viability. In group II, the large adrenal medullary cells had evident euchromatin nuclei fused with neurons, and there was an increase in vascularization. Conclusions: Three weeks after transplantation surgery, it was determined that iloprost maintained the viability of the graft tissue and probably prevented apoptosis, and facilitated the integration of the graft tissue into the host brain.Öğe Effects of Recombinant Human Erythropoietin on Mandibular Distraction Osteogenesis(W B SAUNDERS CO-ELSEVIER INC, 2009) Mihmanli, Ahmet; Dolanmaz, Dogan; Avunduk, Mustafa C.; Erdemli, EsraPurpose: To evaluate the effects of subcutaneous administration of recombinant human erythropoietin (rHuEPO) oil regeneration formation and quality during mandibular distraction osteogenesis. Materials and Methods: Sixteen adult male New Zealand rabbits were Used ill this study Ethical approval was obtained front the Animal Research Institute of Selcuk University, Konya, Turkey Subjects were randomly divided into 2 groups Distraction osteogenesis (DO) was performed witha Custom-made distractor on the left mandibles of rabbits. In the experimental group, 4 doses of 150 IU/kg rHuEPO wet-administered at 48-hour intervals. The first close was given immediately after surgery. Control subjects received 0 5 mL/kg isotonic solution in the same manner After 2 clays of latency, mandibles were distracted I mm/day at 12-hour intervals for 5 clays. A 5-mm lengthening was achieved. All animals were sacrificed after 30 days of consolidation Afterward, samples were prepared for histomorphometric evaluation of newly formed bone area. Results: The number of osteoblasts and blood vessels was significantly higher, whereas the number of osteoclasts was significantly lower, ill the experimental group than in the control group (P < 05) In the experimental group. the area of new bone formation was greater than in the control group (P < .05). Moreover. fibroblast and collagen numbers per Unit area were higher in the experimental group However, this finding was not statistically significant (P > 05) Conclusion: The subcutaneous administration of rHuEPO improves the rate and quality of bone-healing during distraction osteogenesis. However, the short-term favorable effects of rHuEPO in tills study should be extended with long-term investigations before clinical application. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67-2337-2343, 2009Öğe Histomorphological Differences of Spermatic Cords regarding Subinguinal versus Inguinal Levels: A Cadaveric Study(KARGER, 2009) Tuccar, Eray; Yaman, Onder; Erdemli, Esra; Zeyrek, Tugba; Esmer, Ali Firat; Kilic, Ozcan; Avunduk, Mustafa CihatAim: Varicocele is a common disorder among male population and is the most common cause of secondary infertility. Microsurgical inguinal or subinguinal operations are the preferred approaches but the two differ in technical difficulty. Therefore, we examined the histomorphological differences of spermatic cords at both subinguinal and inguinal levels in this cadaveric study. Methods: Spermatic cords from 9 adult male cadavers were examined at both the inguinal and subinguinal levels using a light microscope with an image analysis program in the anatomy and histology laboratories of Ankara University Medical School between July 15, 2006 and February 15, 2007. Results: In terms of number and wall thickness, we did not observe any significant histomorphological differences in spermatic cord veins and arteries between the subinguinal and inguinal levels. Conclusion: We conclude that the subinguinal approach is not a harder technique than the inguinal approach concerning vessel dissection, but more studies must be made to compare subinguinal versus inguinal varicocelectomy. Copyright (C) 2009 S. Karger AG, BaselÖğe Prevention of Renal Damage by Alpha Tocopherol in Ischemia and Reperfusion Models of Rats(Springer-Verlag, 2003) Avunduk, Mustafa Cihat; Yurdakul, Talat; Erdemli, Esra; Yavuz, AyşeIschemia-reperfusion injury in rat kidneys most probably comes from oxidative stress, but the possible preventive effect of alpha-tocopherol (AT) treatment on this injury has not yet been established. Forty male Wistar rats were randomly divided into four groups. The left renal arteries of all rats except the controls were clamped to induce renal ischemia. The left kidneys of the rats in the ischemia group were removed following 40 min ischemia. The rats in the ischemia-reperfusion and ischemia-reperfusion-AT groups were treated similarly, but in these groups the renal arteries were re-perfused for 1 h following ischemia. The rats in the ischemia-reperfusion-AT group also received 10 mg/kg AT 3 h prior to ischemia. The specimens were examined histopathologically and ultrastructurally, and the tissue calcium levels were measured. Light microscope and ultrastructural examination showed that the greatest damage occurred in the ischemia-reperfusion group. The highest level of tissue calcium was also found in this group. In the ischemia-reperfusion-AT-treated group, less tissue damage and a lower tissue calcium concentration was found compared to both the ischemia and ischemia-reperfusion groups. Our results indicate that AT can reduce tissue damage after ischemia-reperfusion injury.Öğe The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study(TERMEDIA PUBLISHING HOUSE LTD, 2018) Sert, Ibrahim Unal; Kilic, Ozcan; Akand, Murat; Saglik, Lutfi; Avunduk, Mustafa Cihat; Erdemli, EsraIntroduction: Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. Material and methods: A total of 30 male Sprague-Dawley rats were divided into 3 groups. The first group constituted the control group. The second group was given i.v. ZA of 3 mg/kg once every 3 weeks for 12 weeks from the tail vein. The third group received the same dosage of ZA with an additional i.m. injection of 15 mg Vit-E every week for 12 weeks. Tissues were taken 4 days after the last dose of ZA for histopathological and ultrastructural evaluation. Paller score, tubular epithelial thickness and basal membrane thickness were calculated for each group. Results: For group 2, the p-values are all < 0.001 for Paller score, epitelial thickness, and basal membrane thickness. For group 3 (ZA + Vit. E), the p-values are < 0.001 for Paller score, 0.996 for epitelial thickness, and < 0.001 basal membrane thickness. Significant differences were also observed in ultrastructural changes for group 2. However, adding Vit-E to ZA administration reversed all the histopathological changes to some degree, with statistical significance. Conclusions: Administration of ZA had nephrotoxic effects on rat kidney observed under both light and electron microscopy. Concomitant administration of Vit-E significantly reduces toxic histopathological effects of ZA.
