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Öğe Influences of size, shape and surface chemistry of gold nanoparticles on dipeptide self-assembly(AMER CHEMICAL SOC, 2014) Erdogan, Hakan; Sakalak, Huseyin; Yavuz, Mustafa Selman; Demirel, Gokhan[Abstract not Available]Öğe Laser-Triggered Degelation Control of Gold Nanoparticle Embedded Peptide Organogels(AMER CHEMICAL SOC, 2013) Erdogan, Hakan; Sakalak, Huseyin; Yavuz, Mustafa S.; Demirel, GokhanFurther understanding of the interactions between nanoparticles (NPs) and biological molecules offers new possibilities in the applications of nanomedicine and nanodiagnostics. The properties of NPs, including size, shape, and surface functionality, play a decisive role in these interactions. Herein, we evaluated the influences of gold NPs (AuNPs) with different sizes (5-60 nm) and shapes (i.e., spherical, rod, and cage) on the self assembly of diphenylalanine (Phe-Phe) dipeptides. We found that the size of AuNPs smaller than 10 nm did not affect the self-assembly process of Phe-Phe, while bigger AuNPs (>10 nm) caused the formation of starlike peptide morphologies connected to one center. In the case of shape differences, nanorod and nanocage morphologies acted differently than spherical ones and caused the formation of densely packed, networklike dipeptide morphologies. In addition to these experiments, by combining photothermal properties of AuNPs with a Phe-Phe-based organogel having a thermo-responsive property, we demonstrated that the degelation process of AuNPs embedded organogels may be controlled by laser illumination. Complete degelation was achieved in about 10 min. We believe that such control may open the door to new opportunities for a number of applications, such as controlled release of drugs and tissue engineering.Öğe Light-Driven Unidirectional Liquid Motion on Anisotropic Gold Nanorod Arrays(WILEY-BLACKWELL, 2015) Yilmaz, Mehmet; Kuloglu, Hamit Bugra; Erdogan, Hakan; Cetin, Saime Sebnem; Yavuz, Mustafa Selman; Ince, Gozde Ozaydin; Demirel, Gokhan[Abstract not Available]Öğe Morphological Versatility in the Self-Assembly of Val-Ala and Ala-Val Dipeptides(AMER CHEMICAL SOC, 2015) Erdogan, Hakan; Babur, Esra; Yilmaz, Mehmet; Candas, Elif; Gordesel, Merve; Dede, Yavuz; Oren, Ersin EmreSince the discovery of dipeptide self-assembly, diphenylalanine (Phe-Phe)-based dipeptides have been widely investigated in a variety of fields. Although various supramolecular Phe-Phe-based structures including tubes, vesicles, fibrils, sheets, necklaces, flakes, ribbons, and wires have been demonstrated by manipulating the external physical or chemical conditions applied, studies of the morphological diversity of dipeptides other than Phe-Phe are still required to understand both how these small molecules respond to external conditions such as the type of solvent and how the peptide sequence affects self-assembly and the corresponding molecular structures. In this work, we investigated the self-assembly of valine-alanine (Val-Ala) and alanine-valine (Ala-Val) dipeptides by varying the solvent medium. It was observed that Val-Ala dipeptide molecules may generate unique self-assembly-based morphologies in response to the solvent medium used. Interestingly, when Ala-Val dipeptides were utilized as a peptide source instead of Val-Ala, we observed distinct differences in the final dipeptide structures. We believe that such manipulation may not only provide us with a better understanding of the fundamentals of the dipeptide self-assembly process but also may enable us to generate novel peptide-based materials for various applications.
