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  • Küçük Resim
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    Clinical and Laboratory Data of Primary Hemophagocytic Lymphohistiocytosis: A Retrospective Review of the Turkish Histiocyte Study Group
    (Galenos Yayıncılık, 2010) Fışgın, Tunç; Patıroğlu, Türkan; Özdemir, Akif; Celkan, Tiraje; Çalışkan, Ümran; Ertem, Mehmet; Yaralı, Neşe; Erduran, Erol; Vergin, Canan; Canpolat, Cengiz; Duru, Feride; Bay, Ali; Özbek, Namık; Yılmaz Karapınar, Deniz
    Objective: This study analyzes the clinical and laboratory findings of children with primary hemophagocytic lymphohistiocytosis (HLH) followed in various referral centers of Turkey. Materials and Methods: A simple three-page questionnaire prepared by the Turkish Histiocyte Study Group was used for documentation of patient data. Results: Age at diagnosis varied from 0.6 to 78 months (median +/- SD, 16.5 +/- 26.1). Sex distribution was almost equal (F/M= 10/12). The frequencies of parental consanguinity and sibling death in the family history were 100% and 81.1%, respectively. The most common clinical findings were hepatomegaly (100%) and fever (95%). The most common laboratory findings were anemia (100%), hyperferritinemia (100%) and thrombocytopenia (90.9%). Triglyceride and total bilirubin levels in the deceased versus surviving group appear to be high (triglyceride: 394 +/- 183 mg/dl, 289 +/- 7 mg/dl; total bilirubin: 2.7 +/- 6.9 mg/dl, 0.5 +/- 1.2 mg/dl, respectively). Conclusion: We concluded that fever, hepatosplenomegaly, anemia, thrombocytopenia, and hyperferritinemia are the most common clinical and laboratory findings in primary HLH. Increased triglyceride and total bilirubin level at the time of diagnosis might be an indicator of poor prognosis in HLH.
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    Öğe
    Pediatric neutropenic patients care in Turkey
    (AVES YAYINCILIK, IBRAHIM KARA, 2019) Aydın, Zeynep Gökçe Gayretli; Büyükcam, Ayşe; Kara, Ateş; Karbuz, Adem; Soysal, Ahmet; Tapısız, Anıl Aktaş; Parlakay, Aslınur Özkaya; Somer, Ayper; Çalışkan, Ayşe Bahar Budan; Kocabaş, Bilge Aldemir; Okur, Dicle Şener; Çiftdoğan, Dilek Yılmaz; Arısoy, Emin Sami; Kocabaş, Emine; Çiftçi, Ergin; Erduran, Erol; Vardar, Fadıl; Tanır, Gönül; Şensoy, S. Gülnar; Bayhan, Gülsüm İclal; Devrim, İlker; Çelik, Melda; Özen, Metehan; Kosker, Muhammet; Ergüven, Müferret; Dalgıç, Nazan; Hatipoğlu, Nevin; Öz, Fatma Nur; Belet, Nurşen; Akcan, Özge Metin; Ceylan, Özgür; Şiraneci, Rengin; Bozdemir, Şefika Elmas; Özkasap, Serdar; Çelebi, Solmaz; Çelik, Ümit; Camcıoğlu, Yıldız; Kara, Aybüke Akaslan; Küpeli, Begül; Gülhan, Belgin; Albayrak, Eda; Erdeniz, Emine Hafize; Olcay Yasa, Emine; Türkkan, Emine; Tezer, Hasan; Sütçü, Murat; Bayram, Nuri; Hatipoğlu, Sami; Öncel, Selim; Çelik, Taylan; Torun, Yasemin Altuner; Köksal, Yavuz; Çay, Ümmühan; Kara, Ahu; Yörük, Mustafa Asım; Demirdağ, Tuğba Bedir
    Objective: Infection is a common complication in children with malignancies. There is no consistent guidance for environmental infection control and isolation precautions for neutropenic patients (NP). There are differences between centers. The aim of this questionnaire study was to determine these differences in Turkey. Material and Methods: A multicenter-descriptive questionnaire was conducted on 36 centers from different geografical locations of Turkey. Bone marrow transplantation units were excluded. Each center was contacted at least three-times. Questionnaire was answered by two different doctors from each center. Results: Thirty-six centers including 20 (55.5%) University Hospitals, 12 (%33.3) Research Hospitals, three (8.3%) State Hospital and one Private University Hospital participated in this survey. 94.3% of the centers had a bed capacity of 50 beds and over. Twenty-one (58.3%) centers had pediatric infection ward that followed febrile NP. All centers had an infection control committee. 25% (9/36) of the centers always followed pediatric neutropenic fever patients in a single room. 66.6% (24/36) of the centers had toilet in all patients' room. The door features of patients' room included mostly (94.1%, 32/34) manually opened door. Ten (27.7%) centers had hepa filter system, five of them had positive-negative pressure room. Thirteen (38.2%, 13/34) centers prefered hickmann catheter for accessing a patient's central line. Training was given for catheteter care in all centers. Sixteen (44.4%) centers had determined policies about keeping toys in patient rooms. Visitor restrictions were performed in all centers. None of the centers allowed plants or flowers in hospital rooms. There was a neutropenic diet specific for pediatric NP provided in twenty-seven centers (75%). Conclusion: The prevention and control of infection contributes to the improvement of the prognosis of patients with hematological malignancies. Physicians must be aware of the infection risks and take precautions for infectious complications through the neutropenic period and standard protocols should be established and implemented for patients with hematological malignancies.