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Öğe Coexistence of inverted Y, chromosome 15p+ and abnormal phenotype(MEDECINE ET HYGIENE, 1999) Acar, Hasan; Çora, Tülin; Erkul, ICoexistence of inverted I; chromosome 15p+ and abnormal phenotype: In this study: we report conventional and molecular cytogenetic studies in a patient with multiple anomalies who is a carrier of a pericentric inversion on chromosome Y and a chromosome 15p+. His parents were phenotSpically normal. The father is a carrier of a pericentric inversion of chromosome I; and the mother carries a large chromosome 15p+ variant. The inverted Y chromosome was demonstrated bg GTG- and CBG-banding, and DAPI-staining. The presence of extra chromosomal material on the chromosome 15p, that was C-band and DAPI positive, was demonstrated by trypsin G-banding. This suggests that the extra chromosomal material contained repetitive DNA sequences. NOR-staining indicated the presence a nuclear organizer region at the junction of the chromosome 15p+ material. Fluorescence in situ hybridization (FISH), with chromosome X and Y painting probes, alpha- and classic-satellite probes specific for chromosome I: alpha- and beta-satellite III probes for chromosome 15 were used to elucidate the nature of both the inverted Y chromosome and chromosome 15pt. The result with chromosome X and Y painting probes, alpha-satellite, classic-satellite, and DYS59 probes specific for chromosome Y revealed the rearrangement of the Y chromosome was an inv(Y)(p11.2q11.22 or q11.23). FISH with alpha-satellite and beta-satellite III probes for chromosome 15 demonstrated that the extra chromosomal material on the chromosome 15 probably represents beta-satellite III sequences. The possible roles of the simultaneous occurrence of an inverted Y and the amplified DNA sequence on chromosome 15p in the abnormal phenotype of the proband are discussed.Öğe Increased cardiac troponin I concentration in diabetic ketoacidosis(FREUND PUBLISHING HOUSE LTD, 2004) Atabek, ME; Pirgon, O; Oran, L; Erkul, I; Kurtoglu, SObjective: To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. Methods: Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnI), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. Results: At the time of admission, the diabetic patients had significantly higher values than the controls for cTnI (0.193 +/- 0.008 vs 0.176 +/- 0.006 ng/dl; p < 0.001), CK-MB (24.1 < 2.1 vs 22.7 < 1.2 U/l; p = 0.02), and myoglobin (85.5 < 7.4 vs 52.5 +/- 8.3 mug/dl; p < 0.001). The diabetic patients also had significantly higher values than the controls for CK-MB (24 2.1 vs 22.7 +/- 1.2 U/l; p = 0.02) and for myoglobin (78.5 +/- 2.5 vs 52.5 +/- 8.3 mug/dl; p < 0.001) at 24 h. cTnI had normalized in patients at 24 h. All parameters were significantly different between patients with pH greater than or equal to7.0 and patients with pH <7.0. In addition, serum cTnI levels correlated negatively. with blood pH (r = -0.57, p = 0.026) and HCO3- (r = -0.65, p = 0.008) in the patients with diabetic ketoacidosis on admission. Conclusion: Our findings suggest that diabetic ketoacidosis, particularly when severe, has a detrimental effect on the myocardium.Öğe Oxidative stress in childhood obesity(FREUND PUBLISHING HOUSE LTD, 2004) Atabek, ME; Vatansev, H; Erkul, IObjective: To measure products of free radical damage in childhood obesity. Methods: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. Results: D-Roms levels were higher in the obese children than in the non-obese group (33.3 +/- 10.1 mg% of H2O2 vs 22.8 +/- 2.8 mg% of H2O2; p < 0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6 +/- 3.1 mg% of H2O2 vs 27.8 +/- 3.2 mg% of H2O2; p < 0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p < 0.001) and serum total cholesterol (p < 0.001), with the total variance explained being 82%. Conclusion: Our study demonstrates for the first time that there was increased D-Roms levels in ob se children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity.Öğe Prevalence of anti-HAV and anti-HEV antibodies in Konya, Turkey(ELSEVIER SCI IRELAND LTD, 2004) Atabek, ME; Fyndyk, D; Gulyuz, A; Erkul, IObjective: To determine the prevalence of antibodies to hepatitis A (HAV) and E (HEV) Viruses in the different areas of Konya. Methods: Anti-HAV and anti-HEV antibodies were investigated in 210 healthy children randomly selected (100 from rural areas and 110 from urban areas of Konya). None gave a history of previous icterus nor other signs of hepatitis, had received blood transfusion and HAV vaccine, or had been on hemodialysis. Results: Evidence of HAV infection Occurred in children under the age of 6 years. The seroprevalence rate was 67.8% in rural areas and 25.8% in urban areas. This increased rapidly with age and became universal after 11 years of age in both areas. In contrast, HEV infections were not detected until children were 6-11 year olds, and the 5.2% seroprevalence rate ill urban areas and 8.5% seroprevalence rate in rural areas in this age group did not significantly increase in older age group. The prevalence of anti-HAV as well as anti-HEV was significantly higher in children with poor socio-economic conditions in both areas. Conclusions: These results Suggest that HAV infection in rural areas of Konya is widespread and that environmental and socio-economic factors play a major role in its transmission. In contrast, hepatitis E is not a public health problem in Konya. (C) 2003 Elsevier Ireland Ltd. All rights reserved.Öğe Serologic response to hepatitis B vaccination in children with isolated anti-HBc(OXFORD UNIV PRESS, 2006) Atabek, ME; Erkul, I[Abstract not Available]Öğe Testicular changes in newborn rats exposed to phototherapy(SPRINGER VERLAG, 1999) Koç, H; Altunhan, Hüseyin; Dilsiz, A; Kaymakci, A; Duman, S; Oran, B; Erkul, IIn this study we investigated the long-term effects of 72-h continuous phototherapy on the reproductive system of newborn rats. The animals' weight, fertilization rates, and number of newborn and histopathological changes in the gonads in a normal group not exposed to phototherapy and in the test animals were compared. At the age of 24 weeks there were no significant differences between the two groups, apart from the histology of the testicles of the male rats who were exposed to the phototherapy. The study group showed a significantly reduced diameter of the seminiferous tubules when compared to the controls (P < 0.001). It can be postulated that phototherapy may cause histological degenerative changes in the structure of the rat's testes, even though there were no changes in fertilization rates. Further studies are necessary to reveal the effects of phototherapy on humans and to determine the effects, if any, on fertility.
