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Öğe Clofibrate Treatment of Neonatal Jaundice [5](1991) Erkul, I.; Yavuz, H.; Özel, A.; Gabilan, J.C.; Benattar, C.; Lindenbaum, A.[Abstract not Available]Öğe Coexistence of pericentric inversion of chromosome Y and chromosome 15p+ in a case detected with cytogenetic and FISH techniques(KARGER, 1997) Acar, H.; Çora, Tülin; Erkul, I.; Acar, Aynur[Abstract not Available]Öğe Different Clinical Features of Amitraz Poisoning in Children(Arnold, Hodder Headline Plc, 2002) Atabek, Mehmet Emre; Aydın, K.; Erkul, I.Objective: To evaluate clinical experience of amitraz poisoning in children. Methods: In this study, the clinical and laboratory features of amitraz poisoning in 14 children are presented and compared with previous studies. Results: This study revealed that clinical manifestations of poisoning by oral and dermal routes appeared within 30-150 min, and that central nervous system (CNS) depression, which is the most important sign, improved within 6-24 hours and other signs within 24-72 hours. Unlike the findings in other studies, three severe cases in our study had reversible mydriasis and one of them required resuscitation because of cardiopulmonary arrest occurring as a result of serious respiratory depression. In addition, hepatic function test levels had increased in these three cases, and aspiration pneumonitis existed because of emesis in two of them. Conclusion: There is little information in the literature about dermal poisoning. The signs and symptoms of dermal poisoning were relatively mild compared with oral poisoning, and there were no topical signs. The classical signs of alpha(2)-adrenergic stimulation such as marked sinusal bradycardia and mydriasis as reported in many poisoning cases of animals have not been reported before our three severe cases among children.Öğe Effect of Recombinant Human Erythropoietin (R-HuEPO) Therapy on Plasma FT3, FT4, TSH, FSH, LH, Free Testosterone and Prolactin Levels in Hemodialysis Patients(1992) Yeksan, M.; Tamer, Nour; Cirit, Mustafa; Türk, Süleyman; Akhan, Galip; Akkuş, İdris; Erkul, I.The aim of this study was to evaluate the effect of r-HuEPO treatment on free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and prolactin levels in uremic hemodialysis patients. Twenty-four uremic hemodialysis patients were given r-HuEPO with a dose 60 U/kg as intravenous bolus injection at the end of each dialysis session. Once the hematocrit value of the patient had reached a range of 30-35%, the dose was adjusted so as to keep the hematocrit levels constant. Twenty uremic dialysis patients were taken as control group. The above-mentioned hormone levels of patients and control group were determined before and 4 months after r-HuEPO treatment. After the treatment, serum prolactin levels significantly decreased in both sexes (36.8 ± 7.8 vs 22.9 ± 6.3 ng/ml and 78.3 ± 13.3 vs 37.4 ± 10.4 ng/ml male and female, respectively). FT3 and FT4 significantly increased (1.17 vs 1.67 pg/ml, p < 0.05, and 0.64 vs 0.084 ng/dl, p < 0.05, respectively). TSH levels increased but those changes were not significant. There was no change in the level of any hormone in the control group. Also, the sexual functions of eight male patients treated with r-HuEPO improved and menstruation started again in four female patients. We concluded that r-HuEPO treatment especially decreases prolactin level in uremic hemodialysis patients. It is conceivable that correction of elevated prolactin levels could improve sexual disorders in these patients.Öğe Effect of Recombinant-Human-Erythropoietin (Rhuepo) Therapy on Plasma FT(3), FT(4), TSH, FSH, LH, Free Testesterone and Prolactin Levels in Hemodialysis-Patients(WICHTIG EDITORE, 1992) Yeksan, M.; Tamer, Nour; Cirit, Mustafa; Türk, Süleyman; Akhan, Galip; Akkuş, İdris; Erkul, I.The aim of this study was to evaluate the effect of r-HuEPO treatment on free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and prolactin levels in uremic hemodialysis patients. Twenty-four uremic hemodialysis patients were given r-HuEPO with a dose 60 U/kg as intravenous bolus injection at the end of each dialysis session. Once the hematocrit value of the patient had reached a range of 30-35%, the dose was adjusted so as to keep the hematocrit levels constant. Twenty uremic dialysis patients were taken as control group. The above-mentioned hormone levels of patients and control group were determined before and 4 months after r-HuEPO treatment. After the treatment, serum prolactin levels significantly decreased in both sexes (36.8 +/- 7.8 vs 22.9 +/- 6.3 ng/ml and 78.3 +/-13.3 vs 37.4 +/- 10.4 ng/ml male and female, respectively). FT3 and FT4 significantly increased (1.17 vs 1.67 pg/ml, p<0.05, and 0.64 vs 0.084 ng/dl, p<0.05, respectively). TSH levels increased but those changes were not significant. There was no change in the level of any hormone in the control group. Also, the sexual functions of eight male patients treated with r-HuEPO improved and menstruation started again in four female patients. We concluded that r-HuEPO treatment especially decreases prolactin level in uremic hemodialysis patients. It is conceivable that correction of elevated prolactin levels could improve sexual disorders in these patients.Öğe Effect of Vitamin E Therapy on Sexual Functions of Uremic Patients in Hemodialysis(1992) Yeksan, M.; Polat, M.; Türk, S.; Kazancı, H.; Akhan, G.; Erdoğan, Y.; Erkul, I.Twenty-four uremic patients on hemodialysis who had never been treated with vitamin E or related drugs and 12 control patients with normal renal function were studied. Hemodialysis patients were randomly divided into two groups; 12 were treated with oral vitamin E (300 mg/day) for eight weeks and 12 uremic patients and 12 controls were given placebo. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in all patients before and after treatment. After the vitamin E treatment serum prolactin levels were significantly decreased (50.8 vs 15.4 ng/ml, p<0.01). Vitamin E levels were significantly increased (1.11 vs 1.22 mg/dl, p<0.05). Serum FSH, LH and free testosterone were not affected. In the other two groups there were no significant changes. These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients. This might be due to inhibition of central prolactin secretion. Vitamin E inhibits pituitary gland hypertrophy in vitamin E-deficient rats. (Int J Artif Organs 1992; 15: 648-52)Öğe Effect of Vitamin-E Therapy on Sexual Functions of Uremic Patients in Hemodialysis(WICHTIG EDITORE, 1992) Yeksan, M.; Polat, M.; Türk, S.; Kazancı, H.; Akhan, G.; Erdoğan, Y.; Erkul, I.Twenty-four uremic patients on hemodialysis who had never been treated with vitamin E or related drugs and 12 control patients with normal renal function were studied. Hemodialysis patients were randomly divided into two groups; 12 were treated with oral vitamin E (300 mg/day) for eight weeks and 12 uremic patients and 12 controls were given placebo. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in ail patients before and after treatment. After the vitamin E treatment serum prolactin levels were significantly decreased (50.8 vs 15.4 ng/ml, p<0.01). Vitamin E levels were significantly increased (1.11 vs 1.22 mg/dl, p<0.05). Serum FSH, LH and free testosterone were not affected. In the other two groups there were no significant changes. These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients. This might be due to inhibition of central prolactin secretion. Vitamin E inhibits pituitary gland hypertrophy in vitamin E-deficient rats.Öğe Gangrene After Penicillin Injection (A Case Report)(1995) Ozel, A.; Yavuz, H.; Erkul, I.A patient with right lower limb gangrene that developed after penicillin injection is presented. Accidental intraarterial administration of penicillin may cause gangrene necessitating amputation. To avoid this severe complication, every intramuscular injection should be given with meticulous attention to proper technique, with adequate restraint of the patient, and with full knowledge of local anatomy and potential complications.Öğe Gangrene After Penicillin Injection - (A Case-Report)(TURKISH J PEDIATRICS, 1995) Özel, A.; Yavuz, H.; Erkul, I.A patient with right lower limb gangrene that developed after penicillin injection is presented. Accidental intraarterial administration of penicillin may cause gangrene necessitating amputation. To avoid this severe complication, every intramuscular injection should be given with meticulous attention to proper technique, with adequate restraint of the patient, and with full knowledge of local anatomy and potential complications.Öğe Hydrocephalus in Mumps Meningoencephalitis - Case-Report(WILLIAMS & WILKINS, 1995) Oran, B.; Çeri, A.; Yılmaz, H.; Kabakuş, N.; Ayçiçek, A.; Erkul, I.[Abstract not Available]Öğe Hydrocephalus in Mumps Meningoencephalitis: Case Report(1995) Oran, B.; Çeri, A.; Yılmaz, H.; Kabakuç, N.; Ayçiçek, A.; Erkul, I.[Abstract not Available]
