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Öğe Coexistence of Congenital Chylous Ascites and Congenital Hypothyroidism: Case Report(ORTADOGU AD PRES & PUBL CO, 2012) Altunhan, Huseyin; Annagur, Ali; Ertugrul, Sabahattin; Yuksekkaya, Hasan Ali; Ors, RahmiChylous ascites is a rare clinical entity occurring as the result of the extravasation of the chyle into the peritoneal cavity. A 20-day newborn admitted to our clinic with high level of thyroid stimulating hormone (TSH) and abdominal distension was diagnosed with chylous ascites and congenital hypothyroidism after paracentesis. Thyroid hormone supplementation, a diet containing middle-chain triglycerides and octreotide were started. To our knowledge, the patient who recovered completely with the treatment is the first case in the literature with chylous ascites accompanied by congenital hypothyroidism. Thus, in newborns with chylous ascites, congenital hypothyroidism should be considered and the diagnosis should be confirmed with paracentesis. This approach may be beneficial for early diagnosis and treatment. Chylous ascites can be treated successfully with a diet containing middle-chain triglycerides and octreotide.Öğe Comparison of urinary neutrophil gelatinase-associated lipocalin, C-reactive protein and procalcitonin in the diagnosis of late onset sepsis in preterm newborns(TAYLOR & FRANCIS LTD, 2013) Ertugrul, Sabahattin; Annagur, Ali; Kurban, Sevil; Altunhan, Huseyin; Ors, Rahmi[Abstract not Available]Öğe Fully automated simultaneous umbilical arteriovenous exchange transfusion in term and late preterm infants with neonatal hyperbilirubinemia(TAYLOR & FRANCIS LTD, 2016) Altunhan, Huseyin; Annagur, Ali; Tarakci, Nuriye; Konak, Murat; Ertugrul, Sabahattin; Ors, RahmiObjectives: The purpose of this study was to compare the efficacy and safety of two different catheterization techniques of exchange transfusion (ET) used in the therapy of newborn jaundice: fully automated two-way ET technique and the classical one-way ET.Patients and methods: The study included babies at gestational age of >34 weeks. In total, 107 ETs were performed on 86 babies. Totally, the umbilical vein (UV) group included 54 babies having undergone 69 ETs and the UV/UA group included 32 babies having undergone 38 ETs.Results: The declines in bilirubin levels right after ET (p=0.018) and 8h after ET (p=0.014) were higher in the fully automated UV/UA technique than in the classical UV technique. Furthermore, the duration of intensive phototherapy following ET was shorter in the UV/UA method than in the UV method (p=0.003). There was no difference between the two methods in terms of ET-associated complications (p=0.927).Conclusions: In neonatal hyperbilirubinemia, ET with fully automated UV/UA technique is more efficient than the classical ET technique, causing no additional side-effects. It is also more physiological than the classical technique, since it minimizes the fluctuations in the blood volume and intravascular pressure during ET.Öğe The incidence of congenital anomalies associated with cleft palate/cleft lip and palate in neonates in the Konya region, Turkey(CHURCHILL LIVINGSTONE, 2012) Altunhan, Huseyin; Annagur, Ali; Konak, Murat; Ertugrul, Sabahattin; Ors, Rahmi; Koc, HasanAdditional congenital anomalies have often been found in patients with orofacial clefts. We wanted to find out the incidence and type of congenital malformations that may accompany cleft palate (CP) and cleft lip and palate (CLP) in babies born in the Konya region. A total of 121 newborn babies with CP or CLP were prospectively included in the study, and all were assessed in detail for congenital anomalies. Of 121 babies, 86(71%) had CLP and 35 (29%) had CP. There was at least one congenital malformation in 80 (66%) of the cases. Additional congenital malformations were seen in 26 (74%) of the 35 with isolated CP, and 54 (63%) in the 86 patients with CLP (p < 0.05). The most common congenital malformation was congenital heart disease, followed by head and neck anomalies. The most common congenital heart disease was atrial septal defect. A serious chromosomal anomaly was found in 18/121 patients with CP or CLP (15%). Of the 80 babies in whom congenital malformations were found, 31 (39%) had dysmorphic features. While 21 (68%) of dysmorphic cases had isolated CP, 10 (32%) had CLP (p < 0.05). The rates of premature delivery, intrauterine growth retardation, and consanguinity between parents were higher in patients with CP or CLP. The neonatal mortality was 20% (n = 24). Our results indicate that at least one congenital anomaly is also present in about two-thirds of newborn babies with CP and CLP, and these anomalies significantly increase their morbidity and mortality. All newborn babies with CP and CLP should be screened for additional congenital anomalies, particularly of the cardiovascular system. (c) 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.Öğe Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis(WILEY, 2015) Annagur, Ali; Ors, Rahmi; Altunhan, Huseyin; Kurban, Sevil; Ertugrul, Sabahattin; Konak, Murat; Uygun, Saime SunduzBackgroundParaoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment. MethodsA total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated. ResultsIn the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively). ConclusionLow serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.Öğe Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers(WILEY, 2013) Altunhan, Huseyin; Annagur, Ali; Kurban, Sevil; Ertugrul, Sabahattin; Konak, Murat; Ors, RahmiAim The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM). Material and Methods The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n=31) and babies born to normotensive mothers (n=25). Results The PON-1 and TOS levels in the cord blood and venous blood on the 7th day were not significantly different between the two groups; however, the cord blood TAS levels were higher in BBPM (P=0.001), and the TAS levels in the venous blood were higher in the control group (P=0.021). Furthermore, the cord blood PON-1 levels of babies born to severely pre-eclamptic mothers (n=18) were higher than those of babies born to moderately pre-eclamptic mothers (n=13) (P=0.042). There were no differences in the cord blood TAS and TOS levels and venous blood PON-1, TAS, and TOS levels between babies born to severely and moderately pre-eclamptic mothers. Conclusion The increased TAS levels found in the cord blood of BBPM indicate that the fetus is protected against oxidative damage caused by increased oxidative stress in the mother. To the best of our knowledge, this is the first study in the published work investigating PON-1 levels in BBPM.