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Öğe Evaluation of Biocompability of Supramolecular Calixarene on L-929 by Real Time Cell Analysis(IEEE, 2017) Arpaci, P. Uyar; Ozcan, F.; Omar, N.; Ertul, S.The cytotoxicity test is one of the biological evaluation and screening tests that use tissue cells in vitro to observe the cell growth, reproduction and morphological effects by medical devices. Cytotoxicity is preferred as a pilot project test and an important indicator for toxicity evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity. Three types of cytotoxicity test are stated in the International Organization for Standardization 109993-5: Extract, direct contact and indirect contact tests. The xCELLigence real- time cell analysis system shows a significant potential in regards to cytotoxicity in recent years. The proliferation of L-929 were observed in the Real-Time Cell Analysis (RTCA) Systems. Our research directs that calixarene shows no cytotoxicity at a concentration range of 25 to 100 mu g/mL on L929 cells. There were no significant differences between the L929 cell indexes of the control and all testing groups at 24, 48 and 72 h.Öğe MCF-7 Breast Cancer Cell Applications of the Morpholino Grouped p-tert-butylcalixarene Nanofibers(IEEE, 2017) Ahmed, M. F.; Ertul, S.; Ozcan, F.Calixarenes are good carriers for cations, anions and neutral molecules because they are cyclic, can be easily derivatized, and can create molecular sizes of different sizes. Due to these properties, they have a very wide application area [1]. The use of calixarenes obtained by functioning with different functional groups in the transport and release of drugs takes place in the literature. In this study, p-tert-butylcalix[4]arene derivatives with p-nitrobenzyl functional group and then nanofibers of those new synthesis was obtained by using electrospinning method. Produced calixarene nanofiber primary breast cancer cell application [2,3].Öğe Synthesis of New Macrocyclic Lactones and Their Extraction Study(MAIK NAUKA/INTERPERIODICA/SPRINGER, 2008) Bayrakci, M.; Ertul, S.New macrocyclic lactones were synthesized by reaction of 3-bromo-5-(5-tert-butyl-2-hydroxybenzyl)biphenyl-4-ol with appropriate polyethylene glycol-based dicarboxylic acid dichlorides, and their complexes with Mg(ClO4)(2)center dot 6H(2)O, Pb(SCN)(2), NaClO4 center dot H2O, and KClO4 were prepared. The macrocyclic ligands were evaluated as extractants in the transfer of Li+, Na+, K+, Cu2+, Ni2+, and Hg2+ picrates from aqueous to organic phase.Öğe Synthesis of New Type of Macrocyclic Lactones Functionalized with Different Groups and Investigation of Their Metal Binding Abilities(POLISH CHEMICAL SOC, 2009) Ertul, S.; Bayrakci, M.New type of macrocyclic lactones functionalized with different groups were synthesized by reaction of the dihydroxy compounds such as 5a-d with suitable glycolyl chloride such as tri, tetra dicarboxylic acid dichloride derivatives. Their metal complexes with NaClO4 center dot H2O, KClO4 and Ba(ClO4)(2)center dot H2O were studied. Furthermore, their metal-picrate extraction studies with metal salts such as Na+, K+, Cu2+, Ni2+ and Hg2+ from aqueous phase to organic phase were attempted. All the structures of the ligands and complexes were confirmed by H-I-, C-13-NMR, IR, UV-Vis, MS and elemental analyses methods.Öğe Use of Calix[4]arene Nanofibers in the Treatment of MCF-7 Breast Cancer Cells(IEEE, 2017) Ertul, S.; Ozcan, F.Synthesis of the p-tert-butylcalixarene compound with the amino group was carried out as given in Figure 1. The structure of the calixarene compound with the amino group was elucidated by H-1-NMR, FT-IR. After the synthesized compound was prepared in a suitable solvent medium, the nanofibers were withdrawn by electrospinning. The characterization of the nanofibers was performed by SEM.Öğe Use of Humic Acid-based Nanofibers for Dye Removal and Transport(IEEE, 2017) Ayyildiz, H. F.; Ozcan, F.; Ertul, S.; Kara, H.; Aygun, A.A highly efficient nanofibrous adsorbent was prepared by using a mixture of humic acid (HA) and polyacrylonitrile (PAN) in DMF via electrospinning process, and the obtained nanofibrous adsorbent (PAN-HA) was used in copper removal. Owing to the incorporation of functional groups of HA, PAN nanofiber was turned into a material (PAN-HA) exhibiting anionic and cationic dye transfer. The prepared nanofiber mat was found to exhibit a suitable morphology according to the results of scanning electron microscopy, SEM, images. In this study, the removal and transport of HA-doped PAN nanofibers at different ratios (0-100%) at different pH and concentrations of methyl oranj, congo red, rodamin B and navy blue are carried out in a special membrane system. The results were evaluated in the design expert program.Öğe Use of Polymer-free Calixarene Nanofibers in Heavy Metal Extractions(IEEE, 2017) Ozcan, F.; Ertul, S.Polymer free calix[4]arene nanofibers were prepared via new electrospinning method with metal ion adsorption capacity. Two different calix[4]arene derivatives (compound 2 and 3) containing amide functionalities were used in this study, which were fully characterized by HNMR, FTIR and elemental analysis. Calix[4]arene nanofibers were analyzed with different surface characterization techniques such as SEM, TEM and AFM. SEM images of compound 2 and 3 nanofibers reveals there are non-bonded randomly grown fibers with average fiber diameter (AFD) was in the range of 237 to 307 nm for compoud 2 and 203-280 nm for compound. Adsorption study show the SEM-EDX mapping show adsorption of different metal ions (Hg+2, Pb+2, Cu+2, Co+2, Cd+2, Ni+2) on nanofibers. The the adsorption study show Hg+2, Pb+2 and Cu+2 adsorbed on nanofibers particularly at high pH. The maximum adsorption (98 %) was observed at pH 2 for Hg+2.
