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    Effective and rapid removal of cationic and anionic dyes from aqueous solutions using Elaeagnus angustifolia L. fruits as a biosorbent
    (DESALINATION PUBL, 2019) Oymak, Tülay.; Eruygur, Nuraniye.
    This study focused on the removal of both cationic and anionic dye from an aqueous solution using a natural product. Evaluation was made of the biosorption of methylene blue (MB) and Indigo carmine (IC) as a basic dye and an acid dye, respectively, from an aqueous solution using the dried fruits of Elaeagnus angustifolia. The experimental parameters such as pH of the solution, initial dye concentration, and contact time, were optimized to achieve quantitative removal. The quantitative biosorption of dyes was achieved as 200 mg L-1 of MB within 10 min at pH 7, 25 mg L-1 of IC within 10 min at pH 2. The maximum biosorption capacity was 344.8 mg g(-1) for MB and 9.7 mg g(-1) for IC at room temperature. The pseudo-first-order model and pseudo-second-order models were used to explain the biosorption kinetics. The second order model best explained MB and IC biosorption onto E. angustifolia. The experimental results showed that the use of E. angustifolia as a biosorbent is fast and effective, thereby indicating that it could be an attractive alternative for the removal of anionic and cationic dyes from dye wastewater.
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    Estimation of in vitro antioxidant and antimicrobial activity of methanol extracts from Stevia
    (PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2019) Eruygur, Nuraniye.; Atas, Mehmet.; Ucar, Esra.; Ozyigit, Yasar.; Turgut, Kenan.
    In this study, the efficiency of the plant age and growth period on antioxidant and antimicrobial activity of stevia (Stevia rebaudiana Bert.) was investigated. Samples were taken from S. rebaudiana plants of three different ages (2, 3 and 4 years old) and four different growth periods (H1: 1 July, H2: 1 August, H3: 1 September and H4: 1 October). Extracts of sweet herb (S. rebaudiana) were obtained by maceration method with methanol as solvent. The experiments were carried out in completely randomized design with three replications. According to results, the highest antioxidant activity (metal chelating activity of methanol extract from stevia leaf; DPPH Free Radical Scavenging Activity of methanol extract from stevia leaves) was determined from respectively No.2 sample (3 year-old plant harvested in July) and No.1 sample (2-year-old plant harvested in July). The highest antimicrobial and antifungal activity for Escherichia coli and Staphylococcus aureus was determined from No.9, No.10, and No.11 samples (in the order of 3-year-old plant harvested in September, 3-year old plant harvested in October, and 4-year-old plant harvested in November). All of the stevia samples harvested in different age and different periods were showing antimicrobial effect against Pseudomonas aeruginosa, E. faecalis and Candida albicans.
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    In vitro evaluation of the chemical composition and various biological activities of Ficus carica leaf extracts
    (TURKISH PHARMACISTS ASSOC, 2019) Ergül, Mustafa.; Ergül, Merve.; Eruygur, Nuraniye.; Ataş, Mehmet.; Uçar, Esra.
    Objectives: The present study aimed to investigate the inhibitory activities of enzymes related to diabetes mellitus and Alzheimer's disease of the methanol and water extracts of Ficus carica leaf extracts. The bioactive compounds and anticancer, antioxidant, and antimicrobial effects of the extracts were also investigated. Materials and Methods: The bioactive compounds in the extracts were determined by gas chromatography-mass spectrometry. The antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6 sulphonic acid) (ABTS) radical scavenging, total phenol and flavonoid content, ferric reducing power, and iron chelating method. The anticancer, anticholinesterase, and antimicrobial effects were investigated using the XTT assay, Ellman method, and microdilution, respectively. Results: Our results showed that between the water and methanol extracts there was a difference in terms of chemical composition. The antioxidant results suggested that both extracts have strong antioxidant activity. Similarly, both extracts showed strong alpha-glucosidase and alpha-amylase inhibition activity, while the water extract had higher inhibition activity than the methanol extract against acetylcholinesterase and butyrylcholinesterase. The methanol extract of F. carica exhibited significant anticancer activity on MDA-MB-231 cells and showed moderate antimicrobial activities against Escherichia coli and Staphylococcus aureus. Conclusion: Our results suggest that F. carica leaves could be a valuable source for developing a promising therapeutic agent in cancer, diabetes, and Alzheimer's disease.
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    In-vitro antioxidant, a-glucosidase and a-amylase inhibitory activities of crude ethanol extract and fractions of endemic Hyacinthella acutiloba K. perss. & wendelbo bulbus
    (PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2019) Eruygur, Nuraniye.; Dural, Emrah.; Tekin, Mehmet.; Ozpinar, Hulya.
    In the present study, the antioxidant potential as well as the alpha-amylase and alpha-glucosidase inhibitory activity of different extracts of Hyacinthella acutiloba bulbus were investigated using an in vitro model. Antioxidant activity was assayed by the DPPH radical scavenging activity, total phenol content (TPC) and total flavonoid content (TFC), reducing power assay, ferric thiocyanate (FTC) and thiobarbituric acid method (TBA). Among the extracts, n-hexane and chloroform extract of H. acutiloba displayed more activity than other extracts against a amylase and alpha-glucosidase.