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Öğe 677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with Spina bifida occulta [Spina bifida okkultali hastalarda metilentetrahidrofolat redüktaz (MTHFR) geninin C677T ve A1298C polimorfizmlerinin analizi ve biyokimyasal parametrelerinin de?erlendirilmesi](Turkish Neurosurgical Society, 2010) Eser B.; Cosar M.; Eser O.; Erdogan M.O.; Aslan A.; Yildiz H.; Boyaci G.Aim: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. Material and Methods: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. Results: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x2=3.325, P=0.068; x2=1.479, P=0.224; x2=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x2=8.477, P=0.004). The frequencies of the Aand C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x2=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). Conclusion: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.Öğe Intervertebral discitis and epidural abscess formation secondary to repeated epidural injections: A case report(2006) Kalkan E.; Eser O.; Topatan H.I.; Cengiz Ş.L.Objective: In this article our aim was to emphasize the possibility of development of epidural abscess after repeated injections in a patient into the spinal epidural space. Methods: Lumbar magnetic resonance imaging (MRI) was performed due to worsening of low back pain, inability to walk, fever and sweating. Surgical drainage of the abscess was carried out by bilateral L 5 hemi-partial laminectomy. Antibiotic therapy was recommended for two months and neurological examination was normal after 6 months. Results: Two months after repeated injections, the patient was admitted to our clinic with the complaint of low back pain, inability to walk, fever and fatigue. T 2-weighted magnetic resonance (MR) examination of the lumbosacral spine showed spinal epidural abscess at L5-S1 level and concomitant intervertebral discitis. Staphylococcus aureus grew on cultures. Conclusion: The frequent use of invasive procedures into the spinal cord such as epidural injections increases the incidence of abscesses which can cause serious morbidity if recognition of the infectious agent and treatment with appropriate antimicrobial therapy are delayed. © 2006 VSP.Öğe Supratentorial intracerebral haemorrhage following posterior fossa operation [8](2006) Kalkan E.; Eser O.[Abstract not Available]
