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    Chemical Composition of Nigella sativa L. Seeds Used as a Medical Aromatic Plant from East Anatolia Region, Turkey
    (ASIAN JOURNAL OF CHEMISTRY, 2013) Vatansev, Husamettin; Ciftci, Harun; Ozkaya, Ahmet; Ozturk, Bahadir; Evliyaoglu, Nurcan; Kiyici, Aysel
    In this study, chemical composition such as vitamins, fatty acids and trace elements of Nigella sativa L. seeds collected from East Anatolia Region of Turkey were investigated. Fatty acids in the lipid extracts were converted into methyl esters. The methyl esters were extracted with n-hexane, they were separated and quantified by gas chromatography. Fat soluble vitamins were determined by HPLC and the mixture of acetonitrile/methanol (3/1, v/v) was used as the mobile phase. For determination of trace elements levels, solutions from microwave digestion of a certain amount of seeds were analyzed with inductively coupled plasma optical emission spectrometry. Main fatty acids of Nigella sativa L. seeds were found as 66.5 and 23.5 (as relative % peak area) for linoleic acid (18: 2) and oleic acid (18: 1), respectively. The contents of Co, Ni, Fe, Zn, Cu, Mn and Cr were determined as 0.12, 1.48, 117.32, 41.42, 30.26, 28.56 and 2.55 mu g/g (dry matter) respectively. The levels of vitamins were found as 10.19 mu g/g for alpha-tocopherol, 2.28 mu g/g for delta-tocopherol, 0.18 mu g/g for retinol, 1.38 mu g/g for vitamin D-2 1.85 mu g/g for vitamin K-1 and 2.15 mu g/g for vitamin K-2. The Nigella sativa L. seeds were found to be rich in unsaturated fatty acids, vitamins and trace elements, suggesting that they may be valuable for apoptosis and would be appropriate to further studies in this direction.
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    An Ethnobotanical Survey of Inner-West Anatolia, Turkey
    (SPRINGER/PLENUM PUBLISHERS, 2008) Kargioglu, Mustafa; Cenkci, Sueleyman; Serteser, Ahmet; Evliyaoglu, Nurcan; Konuk, Muhsin; Koek, M. Samil; Bagci, Yavuz
    This study is focused on ethnobotanical usages of wild plants growing within the Afyonkarahisar province districts of Sinanpasa, Hocalar and Dazkiri. Ninety local informants in 11 villages were interviewed. A total of 129 different usages of wild plants in the study area were recorded. Out of 650 plant species commonly present, 93 plant taxa (14.3%) belonging to 43 families were used for medicinal (52 citations), foodstuff (37 citations), fodder (14 citations), dye (six citations), firewood (five citations), construction materials (four citations) and miscellaneous purposes (11 citations). At least 15% of the information regarding ethnobotanical uses of wild plants was obtained by showing herbarium voucher samples to the informants. It was noted that Sideritis leptoclada and Verbascum stenostachyum are endemic to Turkey and their endangered status has markedly increased in recent years because of increased collecting for ethnobotanical purposes. Informants indicate that members of the younger generation have a much reduced interest in ethnobotanical knowledge and that this is a danger to the continued use of local plants.
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    The in vivo investigation of apoptotic effects of Nigella sativa on carbon tetrachloride-induced hepatotoxicity
    (NATL INST SCIENCE COMMUNICATION-NISCAIR, 2018) Uysal, Tuna; Ugurtan, Mevlut Han; Sezer, Ela Nur Simsek; Vatansev, Husamettin; Bozkurt, Meryem; Evliyaoglu, Nurcan
    Nigella sativa commonly known as black seed or black cumin has been used for medicinal purposes for centuries. Our purpose in this study is to determine the apoptotic effects of black cumin seed oil (N. sativa) on CCl4 induced hepatoxicity via molecular markers. For this aim, four experimental groups were created and each of them was intraperitoneally exposed to CCl4 (G2), CCl4 + black cumin oil (G3) and black cumin oil (G4) except from control (G1). DNA fragmentation, RT-PCR, and caspase-3 assay were carried out. According to our results, a remarkable morphological anointment was observed at the G2. The G3 had the lower fatty comparing to G2. DNA profiles were visualized and DNA fragmentation was only in the G3. PCR results showed that BAX gene expression fairly rose in the G3 and BCL-2 gene expression was only determined in the G2. Decreased caspase-3 in G2, and the increased of it's in G3, clearly supported the activation of the apoptotic pathway for injured cells. Consequently, our results indicated that the increases of caspase and BAX/BCL-2 rates demonstrated that there was an effective molecular mechanism based on black cumin induced apoptosis in rat liver which leads to the release of cytochrome-c from the mitochondria to the cytosol, finally activating caspase-3 and resultant apoptosis.