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    Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp detonsa
    (ELSEVIER SCIENCE BV, 2017) Formisano, Carmen; Sirignano, Carmina; Rigano, Daniela; Chianese, Giuseppina; Zengin, Gökhan; Seo, Ean-Jeong; Efferth, Thomas
    The apolar organic extract obtained from aerial parts of Centaurea drabifolia Sibth. & Sm. subsp. detonsa (Bornm.) Wagenitz, growing wild in Turkey, was investigated for the first time for its secondary metabolite composition. Seven sesquiterpene lactones belonging to the guaiane class (1-7), including the new compound 4, along with a fatty acid lactone derivative (8), were isolated. The structures of these compounds were established by spectroscopic analysis, including 2D NMR spectroscopic techniques, with the stereostructure of the new guaiane 4 determined with the help of MTPA derivatization. Cytotoxic activities of compounds 1-7 were evaluated against two cancer cell lines, namely acute lymphoblastic leukemia (CCRF-CEM) and its multidrug-resistant subline CEM/ADR5000. Results showed that aguerin B (1) and cynaropicrin (2) showed a potent activity on both cell lines revealing interesting details about the structure-activity relationships in the class of acylated guaiane sesquiterpenes.
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    Chemical Composition and Antibacterial Activity of the Essential Oil of a 1,8-Cineole Chemotype of Mentha aquatica L. Growing Wild in Turkey
    (2005) Senatore, Felice; D’Alessio, Andrea; Formisano, Carmen; Özcan, Musa
    The essential oil from aerial parts of Mentha aquatica L. (Lamiaceae) was obtained by hydrodistillation. The oil content was 0.37% (v/w), on a dry weight basis. The oil composition was analyzed by GC and GC/MS. Altogether 31 compounds were identified accounting for 93.2% of the oil. 1,8-cineole (55.3%) was the most abundant component with appreciable amounts of carvacrol (9.3%) and sabinene (6.7%). The oil shows an interesting antibacterial activity, mostly against Gram + bacteria.