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Öğe Alterations of Serum Leptin Levels in Patients With Nonalcoholic Liver Cirrhosis(Lippincott Williams & Wilkins, 2006) Kayaçetin, Ertuğrul; Kısakol, Gürcan; Gönen, Sait; Dikbaş, Oğuz; Güngör, Kağan; Kayaçetin, Serra; Topcu, Cemile; Kaya, AhmetIn liver cirrhosis, nutritional status is quite impaired, and the current data has shown conflicting results in serum leptin levels of cirrhotic patients. In this study, we aimed to evaluate serum leptin levels in nonalcoholic liver cirrhosis and determine its relationship with anthropometric parameters and liver function. Thirty-three patients (13 males, 20 females) with nonalcoholic cirrhosis and 16 (9 males, 7 females) healthy control subjects were recruited for this study. Serum leptin values were measured in morning samples of both groups by enzyme-linked immunosorbent assay. The mean levels of leptin were not different in nonalcoholic cirrhotic patients when compared with the control group (P = 0.478). Serum leptin values were positively correlated with prothrombin (international normalized ratio) (P = 0.008, r = 0.64) and total bilirubin (P = 0.047, r = 0.488) and were negatively correlated with high-density lipoprotein (P = 0.025, r = 0.666) and albumin (P = 0.009, r = 0.615). No correlation was found between leptin levels and severity of the liver disease. These findings suggest leptin levels do not depend on the degree of liver damage in patients with nonalcoholic cirrhosis of the liver.Öğe Bone and Calcium Metabolism in Subclinical Autoimmune Hyperthyroidism and Hypothyroidism(Japan Endocrine Society, 2003) Kısakol, Gürcan; Kaya, Ahmet; Gönen, Sait; Tunç, RecepBone turnover is reported to increase in favour of resorption in overt hyperthyroidism and the rate of resorption is associated with the levels of thyroid hormones. Hypothyroidism, on the other hand, was shown to cause no disturbance of calcium kinetics and found to associate lower trabecular resorption surfaces and increased bone cortical thickness. Similar studies are very rare in subclinical thyroid disorders and consequently we aimed to examine calcium and bone metabolism in subclinical thyroid disorders. Thirteen patients with subclinical hyperthyroidism secondary to untreated Graves' disease, 20 patients with subclinical hypothyroidism and 10 healthy subjects participated in this survey. Briefly calcium, phosphorus, and creatinine (Cre), urinary deoxypyridinoline (U-DPD) and serum osteocalcin (OC) were measured as biochemical markers for calcium metabolism. Concerning serum Ca and phosphorus levels, there were no differences between three of the groups, but urinary Ca excretion was higher in subclinical hyperthyroid patients compared to control and hypothyroid subjects. Hypothyroid patients had similar U-DPD levels with control subjects (p = 0.218). Serum OC and U-DPD were higher in subclinical hyperthyroid compared to control subjects (p<0.001 and p<0.001 respectively). We demonstrated a higher bone turnover and greater calcium excretion in subclinical hyperthyroid patients. Additionally, we found that subclinical hypothyroidism is not associated with disturbed calcium metabolism. As persistent increase in bone turnover is responsible for accelerated bone loss, patients with Graves' disease may have increased risk for osteoporosis.Öğe Investigation of Serum Crosslinked N-Telopeptides of Type I Collagen (Ntx) Levels and Total Antioxidant Capacity in Patients with Type 2 Diabetes Mellitus(Walter De Gruyter Gmbh, 2010) Kurban, Sevil; Mehmetoğlu, İdris; Gönen, Sait; Akbulut, SevalPurpose: Our aim was to investigate the serum cross-linked N-telopeptides of type I collagen levels and total antioxidant capacity in patients with type 2 diabetes mellitus. Methods: 46 patients with type 2 diabetes mellitus (24M, 22F) aged 41 to 68 years (54.36 +/- 7.92) and 34 healthy controls (17M, 17F) aged 40 to 69 years (52.91 +/- 8.04) were enrolled in the study. Serum cross-linked N-telopeptides of type I collagen levels were measured by enzyme-linked immunosorbent assay method using a commertially available kit, total antioxidant capacity levels were measured by a colorimetric method based on the oxidation of 2,2'-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid) radical and hemoglobin A(1c) levels were measured by high performance liquid chromatography technique. Results and Conclusion: Serum cross-linked N-telopeptides of type I collagen levels of the patients were significantly higher (p<0.01) whereas total antioxidant capacity levels were significantly lower (p<0.05) than those of the controls. Also, there was a significant positive correlation between serum cross-linked N-telopeptides of type I collagen and hemoglobin A(1c) levels (r=0.301, p<0.05) and a significant negative correlation between total antioxidant capacity and hemoglobin A(1c) levels (r=-0.382, p<0.01) in the patients group. In conclusion, our results show patients with type 2 diabetes mellitus have a significantly reduced total antioxidant capacity levels and there is a risk of bone resorption in these patients which can be estimated by measuring serum cross-linked N-telopeptides of type I collagen levels.Öğe Retrotracheal Parathyroid Adenoma Presenting With Mandibular Giant Cell Granuloma(Turkiye Klinikleri, 2009) Çakır, Mehtap; Gönen, Sait; Öz, GülsünFor the past two decades, primary hyperparathyroidism generally has been diagnosed at an asymptomatic stage because of routine biochemical screening. Bone involvement and dental changes are late manifestations of primary hyperparathyroidism, and brown tumors are seen rarely. We present here a case who admitted to the dentistry clinic with left mandibular swelling diagnosed on pathologic examination as giant cell granuloma. Further investigation revealed brown tumors localized to the mandible and was secondary to primary hyperparathyroidism. Primary hyperparathyroidism can present in a variety of ways and should be included in the differential diagnosis of cystic bone lesions, although at present, these lesions are seen rarely.