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    Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock.
    (2003) Bayir A.; Kafali M.E.; Ak A.; Sahin M.; Karagözoglu E.; Gül M.; Karabulut K.
    BACKGROUND: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia. METHODS: Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dimethylsulphoxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured. RESULTS: There were no significant differences among the groups tissue and plasma TBARS and lactate levels. CONCLUSION: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.
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    Prostate myths: What is the prostate awareness in the general male population in Turkey? [Prostat mitleri: Türkiye'deki genel erkek popülasyonundaki prostat farkındalığı nedir?]
    (AVES İbrahim KARA, 2014) Kulaksızoğlu H.; Akand M.; Kılıç Ö.; Gül M.; Kucur M.; Göktaş S.
    Results: A total of 1004 men between the ages of 18-70 were included in the study (mean age 38.0±12.9 years). Of those included, 20.2% were primary school graduates, 8.6% were secondary school graduates, 25.5% were high school graduates, 39.8% were university graduates, and 5.8% had a doctorate or higher education. Of all 1004 men, 31.5% had seen a urologist or attended an interview with a close relative for a PDs-related visit in a urologist’s office; 56.2% reported “prostate” as a disease and only 16.5% as an organ. In terms of beliefs, 50.2% believed that all men had a “prostate,” 5.4% said that sexual activity would cause PDs, 13% thought that sexual activity would prevent PD, 24.9% reported that a rectal exam would affect sexual activity, and 63.5% believed that urinating when squatting would prevent prostate hyperplasia. Prostate cancer transmission to sexual partners was marked as true by 5% of the men. As many as 41.3% of the participants believed that early prostate surgery for BPH would prevent prostate cancer, and 13% reported that sexual activity ceases with prostate surgery and that retrograde ejaculation or anejaculation is the end of sexual activity in men.Conclusion: The survey clearly showed that prostate awareness is still very unsatisfactory in the Turkish male population and that urologists need to better inform the general population. PD knowledge is still lacking throughout all education levels. This is a unique study showing a cross-sectional analysis of the Turkish community; however, the applicability of these results to other communities should be evaluated.Material and methods: A cross-sectional population sampling was performed in the general population for men between the ages of 18-70 with a survey conducted by medical students. The survey consisted of 15 questions addressing different aspects of PDs and common misinformation in the general population. All participants were stratified according to age, degree of education, occupation and whether the person himself or a close relative had visited a urologist for PDs. All questionnaires were anonymous, and patients were informed about the confidentiality of the results.Objective: The aim of the study was to evaluate prostate awareness in the general male population and discover the common misinformation about prostate diseases (PDs). © 2014 by Turkish Association of Urology.
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    Seropositivity of chlamydia pneumoniae in acute ischemic stroke [Akut i?skemi?k strokta chlamydi?a pneumoniae seropozi?fli??i?]
    (Turkish Society of Cerebrovascular Diseases, 2004) Gül M.; Duran A.; Kaya H.; Uca A.U.
    BACKROUND: The aim of our study was to investigate a relation between Acute Ischemic Stroke (AIS) and Chlamydia pneumoniae (CP). METHODS: The study was performed as a clinical prospective study. Totally, 104 healthy volunteers [76 male (73%), 28 female (27%), aged 64±14 years old] and 126 patients with AIS [64 female (51%), 76 male (73%), aged 67±14 years old] applied to Emergency department of Meram Medical School, Selcuk University, between January 01, 2001 and December 31, 2001 were studied. The patients and the controls were compared in respect to their CP seropositivity (CP IgG and CP IgA antibodies). RESULTS: The seropositivity of CP IgA and CP IgG was statistically significant in the patients group compared to that of the control group (p=0. 006 and p=0.001 respectively). CONCLUSION: Our results implies a relation between CP and AIS. Possibility of such a relation deeds to be more investigated.
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    Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility
    (Churchill Livingstone, 2020) Gül M.; Dong L.; Wang D.; Diri M.A.; Andersen C.Y.
    Toxic insult to the gonads by chemotherapy or radiotherapy can lead to permanent infertility. It's an important health concern because each year more than 4000 male patients are at risk of azoospermia in the United States due to gonadotoxicity of the regimens used. There are also several benign/genetic diseases whose natural course can result in infertility without gonadotoxic therapy. Considering the fact that most of these people are cured and survive with the advent of modern medicine, infertility is related to serious psychological and relationship implications and parenthood is a significant issue for those patients. Semen cryopreservation option is available for postpubertal adolescent and adult men, while children do not have this storing option since they do not have mature spermatozoa. However, their testes contain spermatogonial stem cells (SSCs), which are initiators of spermatogenesis. Promising findings in animal studies and human cell lines have encouraged scientists that SSCs may be hope for restoring fertility option of patients who cannot produce functional sperm and who have no other choice to preserve their future fertility. For this reason, several centers around the world already began to collect and cryopreserve testicular tissue or cells with anticipation that SSC-based therapies will be available in the near future; however, an optimal transplantation design in humans is yet to be developed. Here we propose an allogeneic testicular stem cell transplantation with an encapsulation device to restore fertility in patients with infertility. We endeavor to discuss the reliability of this method with the current literature and bring the evidence on its feasibility © 2020 Elsevier Ltd