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Öğe Are all prognostic factors changing with time in breast cancer? New proposal for classification of prognostic factors as time-dependent and time-independent(CHURCHILL LIVINGSTONE, 2005) Altundağ, Kadri; Altundağ, Özden; Boruban, Cem; Altundağ, Muzaffer Bedri; Gündüz, Mehmet[Abstract not Available]Öğe A Case of Late-Term Lead Endocarditis Causing Pacemaker Dysfunction(Churchill Livingstone Inc Medical Publishers, 2010) Kayrak, Mehmet; Sönmez, Osman; Gül, Enes Elvin; Gündüz, MehmetWith regard to pacemakers, lead endocarditis is a rare condition noted for causing difficulties in patient management. It has been reported in the literature that lead endocarditis may occur even after 10 years. In general, the incidence of pacemaker infections has not been carefully documented.1,2 The prevalence and incidence of pacemaker lead dysfunctions due to lead endocarditis have not been researched previously. We present a case of pacemaker dysfunction related to infective endocarditis.Öğe The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus(KOREAN ASSOC INTERNAL MEDICINE, 2015) Arıbaş, Alpay; Kayrak, Mehmet; Tekinalp, Mehmet; Akıllı, Hakan; Alibaşiç, Hayruddin; Yıldırım, Serkan; Gündüz, MehmetBackground/Aims: Poor sleep quality (SQ) is associated with increased cardiovascular mortality and morbidity. Additionally, asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular mortality and morbidity. However, no sufficient data regarding the relationship between ADMA levels and SQ have been reported. The goal of the current study was to evaluate the association between SQ and ADMA levels in normotensive patients with type 2 diabetes mellitus. Methods: The study participants consisted of 78 normotensive type 2 diabetics. The SQ of all participants was assessed using the Pittsburgh Sleep Quality Index (PSQI). Patients with a global PSQI score > 5 were defined as "poor sleepers." Factors associated with poor SQ were analyzed using a multiple regression model. Serum ADMA levels were measured using high performance liquid chromatography. Results: The median ADMA levels of the poor sleepers were increased compared with patients defined as good sleepers (5.5 [4.2 to 6.6] vs. 4.4 [2.9 to 5.4], p < 0.01, respectively). However, the L-arginine/ADMA ratio was decreased in poor sleepers (p < 0.01). Global PSQI scores were positively correlated with ADMA levels (p < 0.01) and negatively correlated with the L-arginine/ADMA ratio (p = 0.02). ADMA levels were correlated with sleep latency (p < 0.01) and sleep efficiency (p = 0.01). Logistic regression analysis showed that ADMA levels (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.16 to 2.44; p = 0.01) and body mass index (OR, 1.15; 95% CI, 1.01 to 1.31; p = 0.04) were associated with poor SQ independently of glomerular filtration rate, sex, age, duration of diabetes, hemoglobin A1c, total cholesterol, and systolic blood pressure. Conclusions: Self-reported SQ was independently associated with ADMA levels in normotensive patients with diabetes mellitus.Öğe White Coat Hypertension and Poor Sleep Quality(ELSEVIER SCIENCE INC, 2013) Kaya, Zeynettin; Kayrak, Mehmet; Demir, Kenan; Gündüz, Mehmet; Alibaşiç, Hayruddin; Karanfil, Mustafa; Akıllı, Hakan[Abstract not Available]