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The Efficacy of Carbamazepine in the Treatment of the Pain Due to Lumbar Lateral Canal Stenosis
(1997) Üstün, M. E.; Özerbil, O. M.; Güney, O.; Kocaoğullar, Y.
In this study, we investigated whether carbamazepine which usually is used in many diseases characterized by neuropathy or neuralgia to reduce pain, has an analgesic effect in patients with lateral canal stenosis. 14 patients (7 women, 7 men) with lateral canal stenosis whose age ranged between 32 and 74 were included in the study. These patients had low back pain and/or sciatica at least for six months and they didn't respond to other medical drugs including nonsteroidal antiinflammatory drugs and analgesics. They were administered 400 mg/bid oral carbamazepine as initial dose for two weeks. When they didn't respond to that dose, it was increased to 800 mg/bid for four weeks. The patients pain were evaluated by the leg pain severity and overall functional disability score before and after treatment. After treatment, the pain was significantly reduced in these patients (p < 0.01, X2:10). In conclusion, we propose carbamazepine in the treatment of lateral canal stenosis as a new alternative drug.