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The correlation of optical cohorence tomography findings with serum cytokine levels, TNF-alpha, serum neopterin levels in relapsing and remitting periods of MS
(SAGE PUBLICATIONS LTD, 2019) Ekmekci, Hakan.; Eren, Fettah.; Ongun, Gözde.; Gedik, Şansal.; Ünlü, Ali.; Öztürk, Şerefnur.
Background: Optical Coherence Tomography (OCT) is an improved technique in the last 20 years that allows quantitative measurement of retinal nerve fiber layer (RNFL) thickness, which provides important information on approach to optic nerve diseases in neurology and ophtalmology area. Therefore, OCT is now being used in various neuro-ophthalmic situations. On the other hand it is known that MS is also involved in a highly complexity of countless biomarkers that are elucitaded an autoimmune disease of the central nervous system. Serum and Cerebrospinal fluid Cytokines, TNF-?, neopterin (a marker of INF-? activity) may play important role in cell swelling, synaptic transmission and neural integration.