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    INVESTIGATION OF THE RELATIONSHIPS OF OBESITY WITH MELATONIN AND DEHYDROEPIANDROSTERONE LEVELS
    (NOBEL ILAC, 2017) Mehmetoglu, Idris; Gokce, Seyid; Kurban, Sevil; Gokce, Recep; Atalar, Mehmet Nuri; Celik, Muhammed
    Objective: Melatonin is synthesized in pineal gland and plays a role in energy metabolism and the weight-reducing effects. Dehydroepiandrosterone (DHEA) is synthesized primarily by the zona reticularis of adrenal cortex and to a lesser degree by the gonads. DHEA has antioxidant, antilipidperoxidative, antiinflammatory, antiatherogenic, antiaging and weight-reducing or preventing effects. Our aim of this study was to investiagate blood DHEA, melatonin, insulin resistance (IR) and lipids levels and correlations between them in obese and nonobese subjects. Material and Method: The study was performed on 33 obese subjects ((16 male (M), 17 female (F)) aged 40.03 +/- 8.47 years and 33 normal weight healty controls (15M, 18F) aged 28.76 +/- 6.22 years. In both groups, DHEA, melatonin, IR, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol and triglyceride levels and correlations between them were investigated. DHEA and melatonin levels were determined by ELISA method and insulin, fasting blood glucose levels and lipid parameters were determined by rutin method using commercially avilable kits. IR was calculated using a formula. Results: There was no statistically significant differences between DHEA and melatonin levels of the groups and there were no correlations between them in both groups. However, there was a significant negative correlation between DHEA and triglyceride levels in the obese group (r=-0.342, p<0.05). Conclusion: Our results show that DHEA and melatonin levels were not changed in obesity and they have no effects on IR. However significant negative correlation between DHEA and triglyceride levels in obese subjects needs to be more investigated in terms of the effect of DHEA on adipose tissue and obesity.
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    The role of intravenous immunoglobulin in the treatment of cerebral vasospasm induced by subarachnoid haemorrhage: An experimental study
    (TAYLOR & FRANCIS LTD, 2011) Cengiz, Sahika Liva; Erdi, Mehmet Fatih; Avunduk, Mustafa Cihat; Tosun, Murat; Ustun, Mehmet Erkan; Gokce, Recep; Yosunkaya, Alper
    Objectives: The aim of this study was to determine whether intravenous immunoglobulin (IVIG) prevents cerebral vasospasm in rabbits with induced subarachnoid haemorrhage (SAH). The effect of IVIG on apoptosis in the endothelial cells of the basilar artery was also evaluated. Methods: Eighteen New Zealand white rabbits were allocated randomly into three groups. SAH was induced by injecting autologous blood into the cisterna magna. Group 1, the control group, was subjected to sham surgery (no induction of SAH). Group 2 had SAH alone and Group 3 had SAH plus IVIG. Three days after treatment, the animals were sacrificed. The basilar artery tissues were analysed histologically and the malondialdehyde levels in the brain stem tissues were evaluated biochemically. Results: Differences in the histopathological luminal areas and full wall thicknesses in the SAH plus IVIG group and the SAH group were statically insignificant (p > 0.005). The malondialdehyde level was also found to be lower in the IVIG group than in the SAH group, although this difference was not significant (p > 0.005). Conclusion: Although the IVIG treatment was revealed to have no vasodilator effect on the SAH-induced spastic basilar artery, it was shown to have a beneficial effect on the apoptosis of endothelial cells, probably via anti-inflammatory mechanisms.