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Öğe The analysis of daily pollen counts in Middle Anatolia: is there any relationship between allergic diseases and meteorological factors?(WILEY-BLACKWELL, 2011) Kizilpinar, I; Dogan, C.; Yavuz, S.; Artac, H.; Sahiner, U.; Buyuktiryaki, B.; Gokturk, B.[Abstract not Available]Öğe CD3G Gene Defects in Familial Autoimmune Thyroiditis(WILEY, 2014) Gokturk, B.; Keles, S.; Kirac, M.; Artac, H.; Tokgoz, H.; Guner, S. N.; Caliskan, U.The patients with CD3 deficiency can present with different clinical findings despite having the same homozygous mutation. We report three new CD3gamma-deficient siblings from a consanguineous family with a combined T-B+NK+ immunodeficiency and their variable clinical and cellular phenotypes despite the same homozygous mutation of the CD3G gene (c.80-1G>C). We also re-evaluate a previously reported non-consanguineous family with two CD3gamma-deficient siblings with the same mutation. The median age at diagnosis was 11years (14months-20years). We found all five patients to display autoimmunity: autoimmune thyroiditis (n=5), autoimmune haemolytic anaemia (n=2), immune thrombocytopenia (n=1), autoimmune hepatitis (n=1), minimal change nephrotic syndrome (n=1), vitiligo (n=1) and positive antinuclear antibodies (n=3) as well as high IgE (n=2) and atopic eczema (n=2). While CD3(+)TCR+T cell percentages were low in all patients, only one had lymphopenia and 3 had CD3(+)T cell lymphopenia. Strikingly, we report frequent and multiple autoimmunity in tested heterozygous carriers in both families (n=6; in 67%), and frequent autoimmunity in family members not available for testing (n=5, in 80%). The results suggest that CD3G should be studied as a candidate gene for autoimmunity and that CD3gamma deficiency should be considered among other primary immunodeficiencies with predominantly autoimmune manifestations.Öğe The effects of meteorological data on the pollen amounts of tree taxa existing in Konya atmosphere in 2008-2009(WILEY-BLACKWELL, 2011) Kizilpinar, Y.; Gokturk, B.; Dogan, C.; Karabulut, E.; Artac, H.; Reisli, Y.[Abstract not Available]Öğe The effects of meteorological parameters on the pollen amounts of Poaceae, Asteraceae, Chenopodiaceae/Amaranthaceae, Rumex and Plantago taxons determined in Konya city atmosphere in 2009(WILEY-BLACKWELL, 2010) Kizilpinar, I; Dogan, C.; Artac, H.; Gokturk, B.; Keles, S.; Reisli, I[Abstract not Available]Öğe The ischemia-modified albumin in childhood acute asthma exacerbation(WILEY-BLACKWELL, 2010) Karagol, C.; Kiyici, A.; Keles, S.; Artac, H.; Kirac, M.; Gokturk, B.; Reisli, I[Abstract not Available]Öğe NEW PROGNOSTIC LABORATORY PARAMETERS AND USE OF INTRAVENOUS IMMUNOGLOBULIN G REPLACEMENT FOR SEVERE H1N1 INFECTIONS IN CHILDREN(SPRINGER/PLENUM PUBLISHERS, 2012) Gokturk, B.; Pekcan, S.; Emiroglu, M.; Guner, S. N.; Kirac, M.; Keles, S.; Artac, H.[Abstract not Available]Öğe The prevalences of allergic diseases in rural and urban areas are similar(ELSEVIER ESPANA SLU, 2011) Guner, S. N.; Gokturk, B.; Kilic, M.; Ozkiraz, S.Background: In this study, we aimed to detect the influence of environmental and socioeconomic factors for asthma, allergic rhinitis, and eczema among children aged 6-18 years. Method: Two each of schools located in urban and in rural areas were included in the study. Children in these schools were asked to respond to 32 questions in total, including demographic and socioeconomic features and the questions of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire form. Results: The average age of children included in the study was 11.5 +/- 3.3 years, and the ratio of boys (55.4%) to girls (44.6%) was 1.2/1. The prevalence of asthma was found as 11.5%, allergic rhinitis as 22.1%, and eczema as 10.7%. Asthma (21.9%), allergic rhinitis (44.3%) and eczema (19.8%) were more frequent in cases which had family history of atopy (p < 0.001). Although there were differences between regions regarding income and educational levels, number of persons in the household, duration of breast feeding, and dietary habits, these variants were found inconclusive for the development of asthma. The risk of progression to asthma and atopic diseases decreased as age increased and the educational level of the father increased. Conclusion: According to our results, atopic diseases can be considered frequent in Konya, history of atopy in the family is the most predictive factor and the effects of rural or urban factors are not obvious in atopic disease development. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.Öğe Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences' -- 2(WILEY-BLACKWELL, 2010) Keles, S.; Artac, H.; Kara, R.; Gokturk, B.; Ozen, A.; Reisli, I[Abstract not Available]
