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    Cornea in PCOS patients as a possible target of IGF-1 action and insulin resistance
    (SPRINGER HEIDELBERG, 2014) Kebapcilar, Ayse Gul; Tatar, Mehmet Gurkan; Ipekci, Suleyman Hilmi; Gonulalan, Gulsum; Korkmaz, Huseyin; Baldane, Suleyman; Celik, Cetin
    Previous studies suggest that serum IGF-1 is higher in women with polycystic ovary syndrome (PCOS). The ophthalmologic effects of IGF-1 excess have not yet been investigated in women with PCOS. The aim of the current study is to compare the corneal thickness of patients with PCOS and those of healthy subjects. Forty three patients with PCOS and 30 age-matched and gender-matched healthy individuals were enrolled in this cross-sectional study. Central corneal thickness (CCT) was measured in patients with PCOS and in healthy individuals with an ultrasound pachymeter. IGF-1 values were also determined in the study group. Women with PCOS had significantly higher levels of IGF-1 and homeostasis model assessment (HOMA-IR) levels than the control group. Right and left CCT measurements were higher in the PCOS group than in the control group. A positive correlation between IGF-1 and right and left CCT was identified in both groups. In multiple linear stepwise regression analyses, IGF-1 independently and positively associated with HOMA-IR in women with PCOS. A correlation between total testosterone and CCT was identified in the whole group. In multiple stepwise regression analyses, total testosterone independently and positively associated with left central corneal thickness in the whole group. These findings indicate that PCOS has target organ effects on the eye. Consequently, it can change central corneal thickness. Higher IGF-1 levels seem to be the main causes of increased corneal thickness. Insulin resistance in PCOS is one of the underlying causes and promotes increase in IGF-1. We suggest a careful and detailed corneal evaluation in PCOS patients to prevent the potential risk of increased CCT, in addition to the already-known complications.
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    Do We Need to Replace GH to Correct Anemia in Hypopituitarism?
    (ENDOCRINE SOC, 2014) Kulaksizoglu, Mustafa; Ipekci, Suleyman Hilmi; Gonulalan, Gulsum; Ozturk, Mine; Kaya, Ahmet; Gonen, Mustafa Sait; Cakir, Mehtap
    [Abstract not Available]
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    The Effect of Hypothyroidism on Color Contrast Sensitivity: A Prospective Study
    (KARGER, 2015) Cakir, Mehtap; Ozturk, Banu Turgut; Turan, Elif; Gonulalan, Gulsum; Polat, Ilker; Gunduz, Kemal
    Background: Thyroid hormone has been shown to control retinal cone opsin expression, the protein of color vision, in adult rodents. Objectives: The aim of this study was to evaluate the effect of hypothyroidism on color contrast sensitivity in adult overt hypothyroid patients. Methods: Thirtyeight overt hypothyroid (31 females, 7 males) subjects and 20 euthyroid (16 females, 4 males) controls were studied prospectively. Color vision examination was performed by Chromatest, a software program analyzing the tritan (blueyellow) color contrast threshold (tritan CCT) and protan (redgreen) color contrast threshold (protan CCT). Color contrast sensitivity analyses of hypothyroid subjects were performed on admission and after L -thyroxine treatment when biochemical euthyroidism was achieved. Results: After a median period of 90 (90-210) days, 24 (19 females, 5 males) patients were euthyroid and eligible for a second color vision examination. Baseline tritan CCT and protan CCT values were significantly higher in the hypothyroid group compared to euthyroid controls, which clinically translates into impaired color contrast sensitivity (p < 0.001 and p < 0.001, respectively). There was a significant decrease in tritan CCT (p = 0.002) and protan CCT (p < 0.001) values in the hypothyroid group after euthyroidism was achieved, which denotes improvement in color contrast sensitivity. Conclusions: It is a novel finding of the current study that color contrast sensitivity is impaired in hypothyroidism and significantly improves after euthyroidism is achieved. (C) 2015 European Thyroid Association Published by S. Karger AG, Basel