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Öğe DOES PREOPERATIVE ADMINISTRATION OF ALLOPURINOL PROTECT THE LUNGS FROM ISCHEMIA-REPERFUSION INJURY OCCURED DURING CARDIOPULMONARY BYPASS?(SPRINGER TOKYO, 2009) Ergene, Neyhan; Gormus, Zulfikare Isik; Celik, Jale Bengi; Gormus, Niyazi; Solak, Hasan[Abstract not Available]Öğe The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women(HUMANA PRESS INC, 2008) Sunar, Fusun; Gormus, Zulfikare Isik; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimThe objective of the present study is to investigate how low-dose zinc supplementation for 2 weeks in the post-menopausal period influences levels of estrogen and progesterone in the serum. The study registered 32 natural menopause patients, who were allocated to four groups with equal number of patients. Group 1, control group, which was not subjected to any procedure. Group 2, the group that was supplemented with 15 mg/day zinc sulfate for 2 weeks. Group 3, the group that was given hormone replacement therapy (0.625 mg estrogen+ 5 mg medroxyprogesterone acetate/day) for 2 weeks. Group 4, the group that received hormone replacement therapy (0.625 mg estrogen+5 mg medroxyprogesterone acetate/day) and zinc sulfate (15 mg/day) for 2 weeks. Blood samples were collected twice from each subject, once at the beginning of the study, and once at the end of the 4-week procedure to determine estrogen (E2) and progesterone levels. Variance analysis was employed in the statistical evaluation of data. Level of significance was set at p < 0.05. No significant difference was found between the estrogen and progesterone levels of groups 1 and 2. Groups 3 and 4 had higher estrogen and progesterone levels than groups 1 and 2 (p < 0.05). Estrogen and progesterone levels in groups 3 and 4 were not different. Results of the study show that low-dose zinc supplementation to post-menopausal women for 2 weeks does not have a significant effect on the concerned parameters.Öğe Preventive Role of Magnesium on Skeletal Muscle Ischemia-Reperfusion Injury-an Experimental Study(HUMANA PRESS INC, 2009) Gormus, Zulfikare Isik; Ergene, Neyhan; Toy, Hatice; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimThe present study aims to explore whether Mg infusion has a preventive effect on ischemia-reperfusion injury in rats. A total of 20 Sprague-Dawley-type adult male rats were used. In group 1 (control), 0.9% isotonic solution was administered. In group 2 (experiment), magnesium sulfate (0.5 mg per 100 g) was administered. Ischemia was induced for 15 min for the two groups. Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination. Mg levels in the experiment group were higher than those in the control group after ischemia-reperfusion (p < 0.05). In the control group, postischemia and postreperfusion IL-8 values were higher than preoperative values (p < 0.05). As for eosinophilia and loss of striation values, these were higher in the experiment group after ischemia-reperfusion than the values in the control group (p < 0.05). Histopathologically, Mg infusion cannot prevent the tissue injury triggered in ischemia-reperfusion periods. Eosinophilia can be one of the major and earliest markers of ischemia-reperfusion injury.