Yazar "Gul, Murat" seçeneğine göre listele
Listeleniyor 1 - 10 / 10
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Benign prostatic hyperplasia and prostate cancer differentiation via platelet to lymphocyte ratio(IOS PRESS, 2015) Kaynar, Mehmet; Yildirim, Mehmet Erol; Gul, Murat; Kilic, Ozcan; Ceylan, Kadir; Goktas, SerdarBACKGROUND: The aim of the current study is to evaluate NLR and PLR inflammation markers in PCa and BPH. METHODS: Clinical and pathological data such as age, prostate volume, PSA, NLR, and PLR levels of 201 patients were retrospectively reviewed. Pathological sample results of these patients were categorized either as benign or malign. The benign group consisted of chronic prostatitis and BPH and the malign group of PCa. The PSA levels were divided into three categories as PSA: 0-4 ng/ml, PSA: 4-10 ng/ml, and 10 ng/ml and above. RESULTS: In the benign category, the mean PLR values for PSA: 0-4 ng/ml is 131.8 +/- 31.2, for PSA: 4-10 ng/ml 124.7 +/- 83.9 and 10 ng/ml and above 124 +/- 53 in chronic prostatitis group and in the BPH group for PSA: 4-10 ng/ml 120.3 +/- 45.1, for PSA: 4-10 ng/ml 126 +/- 54,2, and 10 ng/ml and above 191.4 +/- 176.1. In the malign category, the mean PLR values of PCa patients is for PSA: 0-4 ng/ml 122.8 +/- 43.8, for PSA: 4-10 ng/ml 123 +/- 43.8, and above 10 ng/ml 179.1 +/- 94. Related to the variables of age, NLR, and mean prostate volume, there were no statistically significant differences. Statistically significant differences were observed in the mean PLR values only if the PSA level was 10 ng/ml and above (p: 0.044) in the BPH and PCa groups. The correlation of the PCa Gleason score and PSA, NLR and PLR parameters in the malign category revealed no statistically significant differences (P > 0.05). CONCLUSION: Effective malign and benign differentiation of prostate pathologies based on noninvasive inflammation biomarkers such NLR and PLR necessitate clinical studies with larger patient series.Öğe DRUG RESISTANCE RESTRICTS THE EFFICACY OF SHORT TERM LOW DOSE MITOMYCIN-C TREATMENT IN UMUC-3 BLADDER CANCER CELLS(INIESTARES, S.A., 2018) Gul, Murat; Goktas, Serdar; Kars, Meltem Demirel; Kaynar, MehmetOBJECTIVE: Mitomycin-c (MMC) is the most used intravesical adjuvant agent in non-muscle invasive bladder cancer to prevent recurrence. However, a consensus on about appropriate dosage and treatment schedule of MMC is lacking. We, therefore, aimed to evaluate the most appropriate MMC dosage using an in vitro model of high-grade human bladder cancer. METHODS: UMUC-3 cells, a model for high-grade bladder cancer, were exposed to MMC in different time courses to assess its toxicological effects. XTT cell proliferation kit was used to evaluate the effect of MMC on the proliferation of UMUC-3 cell line. Gene expression analysis for the MDR1, BCL2 and ANXA5 genes was performed by Real-time PCR and flow cytometry analysis were conducted to evaluate the cell death mechanism and acquired resistance after MMC exposure. An ANXA5 kit was used to detect apoptotic cells, and 7-AAD was used to detect necrotic cells. RESULTS: Cell proliferation was prevented to a large extent (IC50, 0.175-0.081 mg/mL) and cytotoxic effects were observed after 5 mu g/mL and 10 mu g/mL MMC administrations for 1 and 2-h, after the 4th and 2nd dose cycles, respectively. Moreover, cell death was observed at 5 mu g/mL and 10 mu/mL MMC applications for 1-h and 2-h by the sixth and second week, respectively. Flow cytometry exhibits increased subpopulation of drug-extruding UMUC-3 cells after a single dose of MMC for 1-h. MMC did not increase the number of apoptotic or necrotic cells; yet, MDR1 (multiple drug resistance) and ANXA5 (apoptotic) expression levels were increased and BCL2 (anti-apoptotic) expression was decreased. Limitations: In-vitro nature of the study and working with only one cell culture are inherit limitations of this project. CONCLUSION: A single dose of MMC administration for 1 or 2-h results in drug-resistance. If maintenance treatment is administered for one hour, it should be continued throughout a 6-week period.Öğe The effect of bladder sensation on uroflowmetry parameters in healthy young men(WILEY, 2016) Kaynar, Mehmet; Kucur, Mustafa; Kilic, Ozcan; Akand, Murat; Gul, Murat; Goktas, SerdarAimsTo investigate the effect of the bladder sensation grade on uroflowmetry parameters. MethodsFifty healthy volunteering young men were enrolled in the present study. In total, three uroflowmetry evaluations were made. Q(max), Q(ave), VV, and PVR urine was obtained three times in three described bladder sensation grades, nearly at the same time of the day. ResultsThe mean age of the participants in the present study is 29.083.8 years. The mean Q(max) values of the volunteers were 17.4 +/- 4.8ml/s, 24.1 +/- 6.0ml/s, and 29.6 +/- 6.5ml/s in the first, second, and third, voiding desire grades, respectively. The mean Q(ave) values were 9.9 +/- 2.1ml/s, 12.9 +/- 2.9ml/s, and 15.9 +/- 4.0ml/s for each of the voiding desire grades mentioned. A statistically significant difference was obvious for all three bladder sensation grades in terms of Q(max) and Q(ave) values (P=0.000). However, no statistically significant difference was seen regarding the PVR urine volumes. The mean voided volume in the first, second and third uroflowmetry were 140 +/- 42ml, 245 +/- 64ml, and 449 +/- 105ml, respectively. The highest Q(max) and Q(ave) values were obtained when the desire to void was urgent. ConclusionsThe findings of the study show that, uroflowmetry evaluations are to be made if the patients have a strong desire to void. Only thus the highest Q(max) values can be obtained; yet, the degree of perceived bladder sensation does not have a statistically significant impact on PVR quantity. Neurourol. Urodynam. 35:622-624, 2016. (c) 2015 Wiley Periodicals, Inc.Öğe Effectiveness of pelvic floor muscle training on symptoms and uroflowmetry parameters in female patients with overactive bladder(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2015) Kulaksizoglu, Haluk; Akand, Murat; Cakmakci, Evrim; Gul, Murat; Seckin, BedreddinBackground/aim: To evaluate the effects of pelvic floor muscle training (PFMT) on symptoms of overactive bladder (OAB) as well as uroflowmetry parameters and functional bladder capacity. Materials and methods: Fifty-nine female patients with OAB symptoms were included. Patients were assessed by SEAPI-QMM, uroflowmetry, and abdominal ultrasound. A specially designed PFMT program using a Pilates ball was generated for patients. The training period was 1-h sessions twice a week for 6 weeks and aerobic home exercises to be performed at home 4 or 5 times every other day. Following training, subjects were reevaluated for body mass index, SEAPI questionnaire, and uroflowmetry. Results: Initial mean SEAPI score, mean maximum and average flow rates, and mean voided volume were 9.8 +/- 7.2, 29.8 +/- 16.4 mL/s, 16.3 +/- 8.7 mL/s, and 211.6 +/- 173.5 mL, respectively. After completion of the training program, SEAPI scores improved significantly to 3.4 +/- 6.4 (P < 0.05). Maximum and average flow rate results did not show significant changes, whereas voided volume seemed to have improved in conjunction with patients' symptom scores (Pearson correlation coefficient: 0.86). Conclusion: According to our results, we think that proper PFMT results in increase of functional bladder capacity as well as improvement in OAB symptoms and can be recommended as first-line therapy or in conjunction with medical therapy in severe cases.Öğe Eosinophilic Cystitis: A Rare Cause of Nocturnal Enuresis in Children(KOWSAR PUBL, 2016) Kilic, Ozcan; Akand, Murat; Gul, Murat; Karabagli, Pinar; Goktas, SerdarIntroduction: Eosinophilic cystitis (EC) is a rare and poorly understood inflammatory condition, characterized by eosinophilic infiltration of all layers of the bladder wall, which mimics bladder tumors. EC may present with symptoms such as increased urination frequency, dysuria, gross/microscopic hematuria, suprapubic pain and urinary retention. Case Presentation: We present a 17-year-old male patient, who was continent night and day in his childhood, and was admitted to our clinic for complaints of hematuria and nocturnal enuresis for the past six months. His history and physical examination were unremarkable, and routine hematological and biochemical tests were normal. Cystoscopy revealed a 4 x 3 cm erythematous, polypoidal, solid lesion on the bladder dome. Histopathological examination of the lesion revealed transitional epithelium with stromaledema, where diffuse, dense infiltration of lamina propria by eosinophils and lymphocytes was also seen. According to these findings, a histopathological diagnosis of EC was made, and the patient was treated with corticosteroids, antimicrobial agents and antihistamines. His symptoms dramatically improved and nocturnal enuresis also recovered after treatment. Conclusions: Although it is a rare entity, EC should be kept in mind in the differential diagnosis of patients presenting with dysuria, hematuria and any kind of acquired voiding dysfunction, including frequency, pollakiuria and incontinence.Öğe Ileo-Cavernosal Fistula after Radiotherapy: A Case Report and Review of the Literature(UROL & NEPHROL RES CTR-UNRC, 2015) Gul, Murat; Islamoglu, Necat; Kaynar, Mehmet; Koplay, Mustafa; Goktas, Serdar[Abstract not Available]Öğe Necessity of routine histopathological evaluation subsequent to bladder neck contracture resection(POLISH UROLOGICAL ASSOC, 2016) Kaynar, Mehmet; Gul, Murat; Kucur, Mustafa; Celik, Esin; Bugday, M. Serdar; Goktas, SerdarIntroduction Bladder neck contracture is a well-known complication following some urologic surgical procedures. Regardless of the surgical procedure, any specimen resected should be submitted for histopathological evaluation worldwide. However, the charges of histopathological evaluation may bring a heavy burden to the hospital and health care system. Also, waiting the period of the pathological evaluation process can be an anxious time for patients. Hence, we aimed to investigate the necessity of routine histopathological evaluation of bladder neck contracture bladder neck contraction specimens. Material and methods Patients undergoing bladder neck contraction resection, from 2010 to 2015 were identified. Patient demographics, type of surgery and histopathological diagnosis and cost of histopathological analyses of the specimens were recorded and analyzed. Results Findings of the histopathologic evaluations of 340 bladder neck specimens were reviewed. Out of these, 294 had underwent transurethral resection of the prostate, 38 open prostatectomy, and 8 radical prostatectomy. Evidence of malignant disease involving prostate cancer was present in only 2 specimens. Both of the specimens had a known preexisting history of malignant disease. The remaining 338 specimens showed chronic inflammation (n = 176), chronic active inflammation (n = 64), adenomatous hyperplasia (n = 78) or cystitis (n = 20). Conclusions Our results indicate that routine histopathological examination of bladder neck contraction specimens is clinically unnecessary. We recommend that the surgeon should decide the need for histological examination on individual basis, depending on known preoperative risk factors.Öğe Role of dual-source dual-energy computed tomography versus X-ray crystallography in prediction of the stone composition: a retrospective non-randomized pilot study(SPRINGER, 2016) Akand, Murat; Koplay, Mustafa; Islamoglu, Necat; Gul, Murat; Kilic, Ozcan; Erdogdu, Merter BoraWe aimed to evaluate the accuracy of determining stone composition with dual-source (DS) dual-energy (DE) computed tomography (CT). A total of 142 patients, diagnosed with urolithiasis and had complete medical records, were included in the study. The number, dimensions, location and CT density of the stones, and dose-length products and effective radiation dose were recorded for every patient. Stone compositions determined with DECT by two radiologists separately were compared with crystallography method. Among 138 stones with a crystallographic result out of 187 stones evaluated, 58 calcium oxalate, 42 hydroxyapatite, 24 uric acid and 10 cystine stones were detected. DECT showed a sensitivity and negative predictive value of 68.67 and 67.5 % for calcium oxalate. Moreover, DECT was found to be very useful in predicting hydroxyapatite and cystine stones with a 100 % sensitivity and negative predictive value. Cohen kappa correlation test showed a substantial agreement (kappa = 0.682) between crystallographic analysis and prediction with DECT-analysis, which was statistically significant (p < 0.001). In this retrospective study, an unenhanced DECT was found to be accurate for in vivo determination of stone type, and thus it can be used easily without any extra burden to the patient or cost while providing additional information.Öğe Selective Low-Dose Spinal Anesthesia for Transrectal Prostate Biopsy: A Prospective and Randomized Study(MARY ANN LIEBERT, INC, 2015) Kucur, Mustafa; Goktas, Serdar; Kaynar, Mehmet; Apiliogullari, Seza; Kilic, Ozcan; Akand, Murat; Gul, MuratPurpose: To evaluate the use of spinal anesthesia by reducing anesthetic agent dose to provide better analgesia with minimal side effects without sacrificing the outpatient setting for prostate biopsy. In this study, efficacy and tolerability of selective low-dose spinal anesthesia versus intrarectal local anesthesia (IRLA) plus periprostatic nerve blockade (PPNB) were compared. Methods: Between September 2012 and April 2013, 100 patients, aged 40 to 80 years, prostate-specific antigen (PSA) 4ng/mL, abnormal digital rectal examinations, and enrolled for biopsy were included in the present study. Ensuring double blindness, pain was assessed using the visual analog scale (VAS). Anal sphincter relaxation, patient satisfaction with the anesthesia technique, and motor response were evaluated. Results: Differences between the two groups, considering age, American Society of Anesthesiologist score, total PSA, prostate volume, anesthesia duration, and cancer presence, were not statistically significant. Pain experienced during probe insertion, biopsy, and 30 minutes after biopsy was significantly lower in the low-dose spinal anesthesia group (P<0.0001). Anal sphincter relaxation degree was significantly higher in the spinal group (P<0.001). Patient procedure-related overall satisfaction level was significantly higher in the spinal anesthesia group (P<0.001). In the spinal anesthesia group, no motor blockade was observed. Between the two groups, no statistically significant difference was seen with regard to complications (P>0.05). Conclusion: Selective low-dose spinal anesthesia provides better pain relief than PPNB plus IRLA without sacrificing the day case setting in ambulatory practice. It is also associated with high patient satisfaction and willingness for a repeated biopsy without differences in procedure duration, tolerance, and complications.Öğe A Study of Uro-oncology Patient Perceptions of Social Support and Hope Levels(KARE PUBL, 2016) Kocak Uyaroglu, Arzu; Gul, Murat; Sari, Emine; Goktas, SerdarOBJECTIVE The present study measured social support perceptions and hope levels of uro-oncology patients diagnosed with cancer and examined how they vary according to sociodemographic variables. METHODS Research was conducted on 143 uro-oncology patients in Konya, Turkey, using a sociodemographic information form, the Multidimensional Scale of Perceived Social Support (MSPSS) and the Hope Scale. RESULTS Patient mean multidimensional perceived social support score was quite high at 62.14 +/- 14.99, and mean hope level score was 20.62 +/- 4.50. Hope level score was significantly higher in male patients. It was also higher for patients with dependents and for patients who believed their cancer was treatable. Perceived social support levels of patients with dependents and patients who believed their cancer was treatable were also significantly higher. CONCLUSION Hope levels of uro-oncology patients are affected positively by high levels of perceived social support. Women, patients with dependents, and patients who develop a positive attitude toward their cancer treatment were more hopeful than others.
