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  • Küçük Resim
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    The distrubition of community-acquired gram negative microorganisms isolated from the urine samples of children, and the evaluation of increase in antibiotic resistance between the years 2003-2010
    (AVES, 2012) Guner, Sukru Nail; Gokturk, Bahar; Bayrakci, Umut Selda; Baskin, Esra
    Aim: Appropriate antibiotic use for urinary tract infection (UTI) will provide protection against antibiotic resistance and complications including renal parenchimal damage and reflux nephropathy which may occur in the future. This study aimed to show the distrubition of community-acquired gram negative microorganisms in the region of Konya and the change in antibiotic resistance rates in time. Material and Method: Patients between 0 and 17 years of age with a positive urine culture between July 2003 and January 2010 were included in the study. 2544 positive cultures were obtained from a total of 1742 patients. Results: : Female patients costituted 57.6 % of the patients who had positive urine culture. Microorganisms isolated from infected female and male patients included E coli (76.1 and 41.9%), Klebsiella spp (13.7 and 24.3%), Proteus spp (6.9 and 28.4%) and the others (3.4 and 5.2%). E.coli, Klebsiella and Proteus species were found to be sensitive to carbapenems, aminoglycosides, quinolones and third generation cephalosporines. High trimetoprim-sulphametoxasol (TMP-SM) resistance in the E.coli and Proteus groups (48.2%-48.5%) and high ampicillin resistance (68.9-88.2%) in the E.coli and Klebsiella groups were remarkable. For all three microorganisms an amikacin sensitivity of 100% was found. When antibiotic sensitivities were compared between the periods of 2003-2006 and 2006-2010, resistance rates of microorganisms against many antibiotics were found to be increased significantly. Conclusions: These data suggested that the microorganisms causing UTI were susceptible to aminoglycosides and third generation cephalosporins. The apparent increase in the resistance rates over a relatively short period was a precarious circumstance. Trimethoprim-sulphamethoxazole and ampicilline should not be the first choice for treatment of UTI because of high resistance rates. (Turk Arch Ped 2012; 47: 107-13)
  • Küçük Resim Yok
    Öğe
    Would mean platelet volume/platelet count ratio be used as a novel formula to predict 22q11.2 deletion syndrome?
    (ALLERGY IMMUNOL SOC THAILAND, 2016) Gokturk, Bahar; Guner, Sukru Nail; Kara, Reyhan; Kirac, Mine; Keles, Sevgi; Artac, Hasibe; Zamani, Ayse Gul
    Background: The diagnosis of 22q11.2 deletion syndrome depends on a time-consuming and expensive method, fluorescence in situ hybridisation (FISH). Objectives: We aimed to determine new parameters which can aid for in the diagnosis of 22q11.2 deletion syndrome. Methods: Twenty two patients with 22q11.2 or 10p13 deletion were evaluated retrospectively. Results: Facial-dysmorphism and mental-motor retardation were detected in 100% of patients. Mean platelet (PLT) counts were lower (224,980 versus 354,000, p = 0.001), mean PLT volume (MPV) (9.95 versus 7.07, p = 0.002), and MPV/PLTx10(5) ratios (5.36 versus 2.08, p < 0.001) were higher in patients with 22q11.2 deletion compared with the control group. Area under the receiver-operator characteristic (ROC) curve was 0.864, sensitivity was 84.6%, specificity was 90.9%, positive predictive value (PPV) was 91.7%, and negative predictive value (NPV) was 83.3% when MPV was 8.6. Area under ROC curve was 0.864, sensitivity was 76.9%, specificity was 90.1%, PPV was 90.1%, and NPV was 76.3% when PLT was 265,500. Area under ROC curve was 0.906, sensitivity was 84.6%, specificity was 100%, PPV was 100%, and NPV was 84.6% when MPV/PLTx10(5) was 3.3. Expression of PLT surface markers which were not in the GPIb-V-IX receptor complex (CD61, CD41a) increased as the surface area increased, but markers which were in a complex (CD42a, CD42b) did not change. Conclusions: High MPV/PLT value can be a good predictor for the diagnosis of 22q11.2 deletion syndrome. We suggest that in patients with facial dysmorphism and retardation in neurodevelopmental milestones and if MPV >= 8.6fl, MPV/PLTx10(5) ratio >= 3.3 and PLT count <= 265,500/mm(3), the patients should be tested by FISH analysis to confirm the 22q11.2 deletion. If there are no macrothrombocytes, the 10p13 deletion should be tested in suspected cases.