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Öğe Effects of gamma-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma(ELSEVIER SCI LTD, 2004) Guney, O; Celik, JB; Arazi, M; Ustun, METhis study aims to evaluate the effects of gamma-hydroxybutyrate (GHB) after spinal cord trauma (SCT). Twenty rabbits were divided equally into four groups: group I was the sham-operated group, group 11 suffered from SCT but received no treatment, group III was given a dose of 400 mg/kg of GHB intravenously before SCT and group IV received the same dose after SCT. Cerebrospinal fluid (CSF) samples were obtained 30 min before SCT (T-0), at 60 (T-1) and 120 min (T-2) after SCT. There was a threefold increase in lactate levels from baseline value at T-2 in group 11, while statistically significant elevation of the lactate levels were not observed in groups III and IV. Glucose levels at T, and T2 were significantly lower in groups III and IV compared with the control group. The findings of this study demonstrate that GHB can control the increase of CSF lactate and glucose levels following SCT and that this metabolic effect may be associated with neuroprotective physiological changes. (C) 2004 Elsevier Ltd. All rights reserved.Öğe Fibrous dysplasia - Response(AMER ASSOC NEUROLOGICAL SURGEONS, 2006) Arazi, M; Guney, O; Ozdemir, M; Uluoglu, O; Uzum, N[Abstract not Available]Öğe Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up - Case report(AMER ASSOC NEUROLOGICAL SURGEONS, 2004) Arazi, M; Guney, O; Ozdemir, M; Uluoglu, O; Uzum, NThe authors report the case of a 53-year-old woman with monostotic fibrous dysplasia of the thoracic spine. The patient presented with a 1-month history of pain in the thoracic spinal region. En bloc resection of the lesion was successfully performed via a transthoracic approach, and a histopathological examination confirmed the diagnosis of fibrous dysplasia. At 24-month follow-up examination, pain and vertebral instability were absent. The findings in this case illustrate that, although very rare, monostotic fibrous dysplasia of the thoracic spine should be considered in the differential diagnosis of spinal tumors. Although a consensus for management of this disease has not been achieved, the authors recommend radical removal of all involved bone as well as internal fixation or bone graft-assisted fusion to achieve long-term stabilization.Öğe Proximal superficial temporal artery to proximal middle cerebral artery bypass using a radial artery graft: an anatomic approach(SPRINGER, 2004) Buyukmumcu, M; Guney, O; Ustun, ME; Uysal, IK; Seker, MWe present the use of radial artery graft for bypass of the proximal superficial temporal artery to the proximal middle cerebral artery. Six adult cadaver sites were used bilaterally. After apterional incision, 2x2-cm minicraniectomy was performed which began 2 cm behind the zygomatic process of the frontal bone. The superficial temporal artery was transsected before exposing the zygomatico-orbital artery branch. The proximal side of the radial artery graft was anastomosed end-to-end to the proximal superficial temporal artery and the distal side end-to-side to the proximal middle cerebral artery. The mean calibers of the proximal superficial temporal artery and largest trunk of the middle cerebral artery were 2.25+/-0.35 mm and 2.3+/-0.3 mm, respectively. The average graft length was 85+/-5.5 mm. We conclude that such bypasses are simpler than proximal middle cerebral artery revascularization using long vein grafts. This method proves that the caliber of the proximal superficial temporal artery is more suited to providing sufficient flow than the distal superficial temporal artery, and the graft is short. Such bypasses to the middle cerebral artery may be an alternative to those from the distal superficial temporal artery or extracranial carotid artery.
