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Öğe Bilateral Papillophlebitis in a Patient with Mutation of Metilenetetrahydrofolate Reductase Enzyme(TURKISH OPHTHALMOLOGICAL SOC, 2016) Guzel, Huseyin; Ozturk, Banu Turgut; Gedik, Sansal; Bakbak, Berker; Beyoglu, Abdullah; Kocak, NadirPapillophlebitis is known as central retinal vein occlusion seen in young patients. It usually presents as unilateral optic disc edema with cotton wool spots and hemorrhage in the peripapillary region. As it may be due to many autoimmune and inflammatory causes, a thorough systemic evaluation of the patient is warranted. In this case report we describe a bilateral, simultaneous papillophlebitis case thought to be related to hyperhomocysteinemia secondary to C677T polymorphism of methylenetetrahyrofolate reductase enzyme.Öğe Characteristics of the Anterior Segment Biometry and Corneal Endothelium in Eyes with Pseudoexfoliation Syndrome and Senile Cataract(TURKISH OPHTHALMOLOGICAL SOC, 2015) Bozkurt, Banu; Guzel, Huseyin; Kamis, Umit; Gedik, Sansal; Okudan, SuleymanObjectives: To evaluate the anterior segment biometric features and corneal endothelial changes in eyes with pseudoexfoliation (PEX) syndrome and senile cataract. Materials and Methods: The central corneal thickness, anterior chamber depth (ACD), pupil diameter, lens thickness, endothelial cell density (ECD), and percentages of polymegathism and pleomorphism of 52 subjects with PEX and cataract were compared with 51 age-and gender-matched control subjects with cataract using optical low-coherence reflectometry (OLCR, Lenstar LS 900; Haag Streit AG, Switzerland) and in-vivo confocal microscopy (Confo Scan 4, Nidek Co. Ltd, Osaka, Japan). Nineteen subjects with PEX syndrome had glaucoma and were using anti -glaucoma medications. Only one eye of the subjects was used in statistical analysis and a p value less than 0.05 was considered statistically significant. Results: None of the OLCR parameters reached statistically significant differences among the 3 groups (ANOVA p>0.05). The percentage of eyes with ACD <2.5 mm was 13.7% in the control group, 24.2% in PEX eyes without glaucoma and 21.1% in PEX eyes with glaucoma, with no statistically significant differences (p=0.45). There was a significant difference in mean ECD among the 3 groups (ANOVA p=0.02), whereas no differences could be found in respect to polymegathism and pleomorphism (p>0.05). Mean ECD was significantly lower in the PEX glaucoma group (2,199.5 +/- 176.8 cells/mm(2)) than the control group (2,363 +/- 229.3 cells/mm(2)) (p = 0.02), whereas no difference was found in mean ECD of PEX eyes without glaucoma and the control group (p=0.42). ECD was less than 2,000 cells/mm(2) in 15.8% of PEX subjects with glaucoma, 9.8% of control subjects and 6.1% of PEX eyes without glaucoma, with no statistically significant difference (p=0.52). Conclusion: As eyes with both PEX glaucoma and cataract seem to be associated with decreased endothelial cell number, specular or confocal microscopy screening should be done for the patients scheduled for intraocular surgery.Öğe The effect and safety of intravitreal injection of ranibizumab and bevacizumab on the corneal endothelium in the treatment of diabetic macular edema(TAYLOR & FRANCIS LTD, 2017) Guzel, Huseyin; Bakbak, Berker; Koylu, Mehmet Talay; Gonul, Saban; Ozturk, Banu; Gedik, SansalObjective: To investigate the effect and safety of intravitreal injection (IVI) of bevacizumab and ranibizumab on corneal endothelial cell count and morphology in patients with diabetic macular edema.Materials and methods: A total of 60 eyes from 60 consecutive patients who received 0.5mg/0.05ml IVIs of bevacizumab (n=30, IVB group) or 1.25mg/0.05ml ranibizumab (n=30, IVR group) for three consecutive months were investigated prospectively. Specular microscopy was performed to evaluate endothelial cell count, the percentage of hexagonal cells (pleomorphism), and the coefficient of variation of the cell size (polymegathism); optical biometry was performed to evaluate central corneal thickness. Results before injection and 1 month after the first and third injections were compared.Results: The groups were matched for age (p=0.11) and gender (p=0.32). There was no significant difference in endothelial cell count (IVB group, p=0.66; IVR group, p=0.74), pleomorphism (IVB group, p=0.44; IVR group, p=0.88) and polymegathism (IVB group, p=0.21; IVR group, p=0.24) before injection or 1 month after the first and third injections. There was also no difference in central corneal thickness (IVB group, p=0.15; IVR group, p=0.58) before injection or 1 month after the first and third injections.Conclusion: Monthly 1.25mg/0.05ml IVIs of bevacizumab or 0.5mg/0.05ml of ranibizumab for three consecutive months in the treatment of diabetic macular edema does not affect corneal morphology and has no harmful effects on the endothelium.Öğe The Effect of Pupil Dilation on Biometric Parameters of the Lenstar 900(LIPPINCOTT WILLIAMS & WILKINS, 2013) Bakbak, Berker; Koktekir, Bengu E.; Gedik, Sansal; Guzel, HuseyinPurpose: To evaluate the effect of pupil dilation on the biometric parameters of the Lenstar LS 900 (Haag Streit AG, Koeniz, Switzerland). Methods: In this cross-sectional study of 33 eyes with cataracts, axial length (AL), anterior chamber depth, intraocular lens (IOL) power, keratometry, and pupil diameter measurements were performed using Lenstar biometry before and after pupil dilatation. Intraobserver repeatability was assessed by taking 2 consecutive recordings of biometric parameters using Lenstar biometry in the undilated pupils of 30 eyes with cataracts. Results: The mean difference in AL measurements from intraobserver readings was -0.001 +/- 0.01 mm. The study group showed a statistically significant change in the first keratometry reading and anterior chamber depth values (P < 0.05); however, the mean difference in AL and IOL power was statistically insignificant between the undilated and dilated pupil Lenstar biometry readings. Three cases in the study group (9.1%) and 1 case in the control group (3.3%) demonstrated changes in IOL power >0.50 diopter. Conclusions: Dilated and undilated pupil size did not affect the measurement of IOL using the Lenstar biometry.
