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Öğe Clinical importance of lipid profile in neonatal calves with sepsis(HELLENIC VETERINARY MEDICAL SOC, 2018) Aydogdu, U.; Coskun, A.; Yildiz, R.; Guzelbektes, H.; Sen, IIn this study, it was aimed to determine of diagnostic importance of blood lipid levels in neonatal calves with sepsis. The study was carried out on a total of 70 calves, 60 with sepsis and 10 healthy calves. The calves with sepsis were included in the study, according to clinical and hematological findings. The blood samples were taken from the V. jugularis for hematological, lipid profile and biochemical analyzes after the routine clinical examinations of the calves. There were significantly (P < 0.05) decrease in body temperature, increase in respiration rate and capillary refill time in the calves with sepsis compared to control group. The levels of blood urea nitrogen, creatinine concentrations of calves with sepsis were significantly higher (P < 0.05), however, levels of total cholesterol, HDL and LDL concentrations were significantly lower (P < 0.05) than control group. In addition, blood triglyceride and VLDL concentrations of calves with sepsis were higher than control group, however there was no statistical difference. In conclusion, serum total cholesterol, HDL and LDL in neonatal calves with sepsis could be used in evaluation of the sepsis in calves.Öğe Effect of colostrum composition on passive calf immunity in primiparous and multiparous dairy cows(CZECH ACADEMY AGRICULTURAL SCIENCES, 2018) Aydogdu, U.; Guzelbektes, H.The aim of this study was to determine the effect of colostrum quality and composition on passive calf immunity in primiparous and multiparous dairy cows. Twenty-four primiparous and 24 multiparous dairy cows were used in this study. Calves born from primiparous dairy cows comprised the first group and calves born from multiparous dairy cows constituted the second group. After birth, colostrum samples were immediately taken from dairy cows. Venous blood samples were collected from the calves before the first colostrum intake and on the 2nd, 7th, 14th and 28th days after the first colostrum intake. Blood and colostrum samples were analysed for biochemical parameters, immunoglobulin and mineral levels. Fat and crude protein levels in colostrum were determined using the Gerber and Kjeldahl methods, respectively. Immunoglobulin levels in the colostrum of multiparous cows were significantly (P < 0.05) higher compared to primiparous cows while fat ratio, LDH activity, Ca, Mg, P and K levels were lower. There was a positive correlation among colostrum immunoglobulin, gamma-glutamyltransferase, crude protein and total protein. Serum immunoglobulin, total protein, globulin and gamma-glutamyltransferase activity in all calves were increased following the colostrum feeding. However, the serum immunoglobulin, total protein, globulin and gamma-glutamyltransferase levels in the second group of calves were higher than those of the first group of calves. There was a positive correlation among serum immunoglobulin, gamma-glutamyltransferase, globulin and total protein. Fe concentrations in all calves decreased over the course of 14 days and were lower in the second group of calves compared to the first group. In conclusion, the results of this study show that the colostrum quality of multiparous cows was better than that of primiparous cows. Colostrum crude protein, total protein, gamma-glutamyltransferase along with colostrum immunoglobulin might be used to determine colostrum quality. Serum immunoglobulin, total protein, globulin and gamma-glutamyltransferase activities could be used to determine the passive transfer status of calves.Öğe Haptoglobin and SAA Concentrations and Enzyme Activities in Bronchoalveolar Lavage Fluids From Calves With Bronchopneumonia(Ecole Nationale Veterinaire Toulouse, 2012) Coskun, A.; Guzelbektes, H.; Simsek, A.; Aydogdu, U.; Sayin, Z.; Sen, I.The aim of this study was to evidence acute phase response in bronchoalveolar lavage fluids (BALF) from calves with bronchopneumonia by measuring Haptoglobin and Serum Amyloid A (SAA) concentrations and some enzyme activities. For that, 30 calves with bronchopneumonia and 8 clinically healthy calves were selected on the basis of the clinical signs and examination and laboratory analysis. Haematological analysis (White Blood Cell counts) was performed using an automated haematology cell counter. In blood and BALF samples, gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activities and the total protein concentrations were measured using an automatic analyzer, whereas Haptoglobin and SAA concentrations were measured with commercially available ELISA kits. Proteinemia, GGT activity, haptoglobin and SAA concentrations in sera from diseased calves were significantly and dramatically increased compared to the healthy controls, while increases in other parameters (leukocyte count, ALP and LDH activities) were not statistically significant. Significant increases in LDH and GGT activities and in concentrations of the 2 acute phase proteins were also evidenced in BALF samples from calves with bronchopneumonia compared to the controls. In addition, except in 2 diseased animals, haptoglobin and SAA concentrations in BALF samples were above 250 and 25 mu g/L, respectively, whereas they have remained below the threshold values in all clinically healthy calves. These results show that BALF haptoglobin and SAA concentrations are useful acute phase proteins (APPs) for the determination of pulmonary inflammation in calves and future studies are needed to determine the importance of local acute phase response in the respiratory system.Öğe Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome(BMJ PUBLISHING GROUP, 2017) Yildiz, R.; Aydogdu, U.; Guzelbektes, H.; Coskun, A.; Sen, I.Hyperlactatemia, hypercapnia, low pH and low oxygen saturation (SatO(2)) are commonly observed in premature calves. These clinical indicators are associated with increased mortality in preterm human newborns with respiratory distress syndrome (RDS). The aim of this study was to investigate the prognostic importance of venous pH, partial pressure of carbon dioxide (pCO(2)) and lactate level and which parameters are related with mortality in premature calves with RDS. All premature calves (52 male/58 female) were admitted to clinic within 12-24 hours after birth and blood samples were also taken into heparinised plastic syringes from the jugular vein within 30 minutes following admission. Diagnosis of RDS was made by both clinical signs and blood gas results. For the evaluation of independent samples, t test was used to compare the venous blood gas indicators of surviving and non-surviving premature calves. Receiver operating characteristics curves were used to determine a cut-off value in terms of lactate and pCO(2) measurements among non-surviving and surviving calves. Venous pH, pCO(2), SatO(2), base deficit, bicarbonate (HCO3) and lactate levels showed a significant variance between surviving and non-surviving calves. Mean venous pH, pCO(2), SatO(2), lactate levels in non-surviving premature calves was 7.05, 78.9 mm Hg, 16.1 per cent and 9.50 mmol/l, respectively. Mean pH, pCO(2), SatO(2) and lactate levels in surviving premature calves were 7.29, 56.3 mm Hg, 25.5 per cent and 5.1 mmol/l, respectively. The cut-off values for lactate and pCO(2) were 7.5 mmol/l and 63.5 mm Hg, respectively. In conclusion, the results of the study show that venous blood lactate and pCO(2) have prognostic importance in premature calves with RDS.
