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    Moderate to Severe Anterior Open-Bite Cases Treated Using Zygomatic Anchorage
    (2012) İleri, Zehra; Karacam, Nejla; Isman, Eren; Kalaycı, Abdullah; Sarı, Zafer
    Anterior open bite is often characterized by excessive vertical development of the posterior maxilla and by excessive eruption of the posterior teeth. Intrusion of the over-erupted molar teeth by traditional orthodontic methods is hardly possible; it requires orthognathic surgery or an absolute skeletal anchorage. These three case reports demonstrate the impaction of the upper molars by using zygomatic miniplates and fixed orthodontic treatment. After treatment, in all cases, the upper molar intrusions and significant correction of open bite were achieved by using zygomatic anchorage, and reduction of vertical dimensions enhanced facial aesthetics.
  • Küçük Resim Yok
    Öğe
    PAX9 Polymorphisms and susceptibility with sporadic tooth agenesis in Turkish populations: a case-control study
    (BIOMED CENTRAL LTD, 2013) Isman, Eren; Nergiz, Suleyman; Acar, Hasan; Sari, Zafer
    Background: Hypodontia, the congenital absence of one or a few teeth is one of the most common alterations of the human dentition. Familial hypodontia is caused by mutations in PAX9, Msx1 and Axin2 genes. Limited numbers of studies are present to show etiological factors beyond this anomaly in Turkish community belonging to Caucasian racial family. The purpose of this study is to investigate the relationships between the two different single nucleotide polymorphisms that are G-1031A and T-912C with hypodontia in Caucasians. 200 individuals having hypodontia and 114 normal individuals having all 32 teeth present were selected for the study. Blood samples were collected from each individual and DNA was extracted. To determine the polymorphisms, PCR-RFLP method was used. Results: The outcomes suggest that the individuals having AC haplotype carry less risk in having hypodontia compared with the rest of the haplotype groups (OR = 3.88; CI = 95%; p = 0.001). The ratio of GT haplotype is less in the hypodontia group meaning that the GT carriers are in risk group in terms of hypodontia risk. Conclusion: These results indicate that polymorphisms in the promoter region of PAX9 gene may have an influence on the transcriptional factors and activity of this gene and are associated with hypodontia in Caucasian individuals.