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    Diagnostic Significance of Aspergillus Species Isolated from Clinical Specimens
    (Selçuk Üniversitesi, Mantarcılık Uygulama ve Araştırma Merkezi Müdürlüğü, 2020) Huseynov, Ravil; Javadov, Samir; Karaltı, İskender; Taqıyev, Bayram; Kadyrova, Hagigat; Asgarova, Shahla; Hashımova, Leyla
    Aspergillosis is an infection caused by Aspergillus, ubiquitous mold found in indoor and outdoor air. In patients with immune suppression and underlying lung diseases Aspergillus spores are able to cause various pathologic conditions. Annually 200000 new cases of invasive aspergillosis (IA) are registered. Mortality due to IA in chronic obstructive pulmonary diseases (COPD) patients varies within 72-95%. 3 million people suffer from different forms of chronic pulmonary aspergillosis (CPA). The aim of the investigation was to determine the incidence of Aspergillus species and their diagnostic significance in clinical samples. Specimens of 1170 patients were investigated for the presence of Aspergillus spp. for period from august 2017 to august 2018. The collected specimens were inoculated onto Sabouraud dextrose agar with chloramphenicol and incubated at 37 ?? temperature for 10 days. In case of growth of mold colonies, further identification was performed based on macroscopic and microscopic features. Growth of Aspergillus spp. colonies were detected in 22 patients (1.88%). 16 of them were males, 6 – females. 7 patients had COPD, 7- bronchial asthma (BA), 4 – pulmonary tuberculosis (PT), 1 – acute respiratory insufficiency, 1 – bronchiectatic disease, 1 – exudative pleurisy and 1 – acute leucosis. Four different species were isolated: Aspergillus niger, A. fumigatus, A. flavus, and A. terreus. A. niger commonly was associated with BA, while in patients with COPD and PT prevailed A. fumigatus. We consider that in patients with COPD and PT risk of aspergillosis should be taken into account in order to provide them with appropriate treatment and reduce mortality rates.
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    Pulmonary Aspergillosis: A Case Report of Invasive Aspergillosis Caused by Aspergillus Fumigatus
    (Selçuk Üniversitesi, Mantarcılık Uygulama ve Araştırma Merkezi Müdürlüğü, 2020) Huseynov, Ravil; Javadov, Samir; Karaltı, İskender; Taqıyev, Bayram
    Aspergillus – a genus consisting of mold species widely distributed in the environment. The spectrum of pulmonary diseases includes invasive aspergillosis (IA), chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA). We report a case of invasive aspergillosis caused by Aspergillus fumigatus in a 65-yearold patient admitted with complaints of shortness of breath, general weakness, and malaise. Diagnosis of “probable” aspergillosis was established based on microbiological and radiological investigations. During microbiological analysis A.fumigatus was isolated an identified based on cultural and morphological characteristics. Despite the medical treatment, the patient’s complaints worsened. He refused artificial lung ventilation apparatus. Probably, chronic obstructive pulmonary disease (COPD) together with late diagnosis and absence of appropriate treatment resulted in the development of IA and lethal outcome. CPA develops in immunocompetent patients, suffering from tuberculosis or other diseases accompanied by the formation of cavities in lungs. This case demonstrates the importance of reliable and timely diagnosis of aspergillosis in order to provide patients with adequate treatment. Taking into account difficulty of obtaining of punctate for histopathological examination and absence of radiological signs physicians should give more attention to the probability of aspergillosis in patients with chronic disease in order to apply adequate therapy and reduce the number of lethal outcomes.