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    Effects of montelukast and zileuton on testicular torsion/detorsion injury in rats
    (WILEY, 2014) Işıkdemir, F.; Kürçer, Z.; Dengiz, Günnur Özbakış; Sipahi, Emine Yılmaz; Banoğlu, Z. N.; Baba, F.; Açıkgöz, S.
    The aim of this study was to evaluate and compare the effects of 5-lipoxygenase enzyme (5-LO) inhibitor zileuton and cysteinyl leukotriene receptor (CysLT1R) antagonist montelukast in testicular torsion/detorsion (T/D) injury model in rats. Rats were anaesthetised with 75mgkg(-1) ketamine hydrochloride and 8mgkg(-1) xylazine intraperitoneal before the operation. Torsion was created by rotating the right testis 720 degrees clockwise and maintained by fixing the testis. The rats were treated with CysLT1R antagonist montelukast (10mgkg(-1); i.p.), 5-LO inhibitor zileuton (3mgkg(-1); i.p.), and vehicle, at 30min prior detorsion. After 1h of torsion, the testis was counter-rotated to the natural position and replaced into the scrotum. Malondialdehyde (MDA) level was measured in testicular tissue after 3h of reperfusion. Histological examination was performed after 24h of reperfusion. T/D caused a significant increase in MDA level and histopathological injury in testes. Montelukast and zileuton treatments prevented the T/D-induced augmentation in MDA levels. Only zileuton treatment significantly reduced the T/D-induced histopathological injury. In this study, we demonstrated for the first time that zileuton had protective effects on testicular T/D injury. We have also found that zileuton is more effective than montelukast on histopathological injury.
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    Multi-organ injuries caused by lipopolysaccharide-induced periodontal inflammation in rats: role of melatonin
    (WILEY, 2014) Gülle, K.; Akpolat, Meryem; Kürçer, Z.; Cengiz, M. I.; Baba, F.; Açıkgöz, S.
    Background and ObjectivePeriodontitis, a chronic inflammatory disease caused by oral bacterial infection, is considered to be a risk factor for systemic diseases including diabetes mellitus, bacterial pneumonia, hyperlipidemia and atherosclerosis. The aim of this study was to evaluate the effectiveness of melatonin against periodontal inflammation-induced multiple organ injury in rats. Material and MethodsEighteen female Wistar albino rats were randomly divided into three groups of six rats each: control; lipopolysaccharide (LPS); and LPS + melatonin. During the experimental period (10d) all rats in the LPS and LPS + melatonin groups were given 10L of LPS (from a 10mg/mL standard solution of LPS dissolved in saline) on days 1, 3 and 5. The rats in the LPS + melatonin group were given 50mg/kg of melatonin, daily for 10d, starting on day 1 after the administration of LPS. All rats were killed at the end of the experimental period. Liver, kidney and lung tissues were removed for investigation by light microscopy. ResultsThe levels of serum aspartate aminotransferase (AST), alanine transaminase (ALT) and blood urea nitrogen (BUN) were significantly increased in the LPS group compared with the LPS+ melatonin group (p<0.05). There was no significant change in the serum creatinine levels in the groups. However, the changes in serum AST, ALT and BUN levels in the experimental groups did not correlate with changes in histological data. Both LPS and LPS + melatonin groups displayed structural features similar to those of the control group. ConclusionThe results revealed that increased serum AST, ALT and BUN levels following periodontitis are ameliorated with melatonin treatment.