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Öğe Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats(ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2007) Altan, Mehmet Fatih; Kanter, Mehmet; Donmez, Senayi; Kartal, Murat Emre; Buyukbas, SadikExtracts of the seeds of Nigella sativa (NS), an annual herbaceous plant of the Ranunculaceae family, have been used for many years for therapeutic purposes, including their potential anti-diabetic properties. The aim of the present study was to test the hypothesis that combined treatment with NS and human parathyroid hormone (hPTH) is more effective than treatment with NS or hPTH atone in improving bone mass, connectivity, biomechanical behaviour and strength in insulin-dependent diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) at a single dose of 50mg/kg. The diabetic rats received NS (2 ml/kg/day, i.p.), hPTH (6 mu g/kg/clay, i.p.) or NS and hPTH combined for 4 weeks, starting 8 weeks after STZ injection. The beta-cells of the pancreatic islets of Langerhans were examined by immunohistochemical methods. In addition, bone sections of femora were processed for histomorphometry and biomechanical. analysis. In diabetic rats, the beta-cells were essentially negative for insltin-immunoreactivity. NS treatment (alone or in combination with hPTH) significantly increased the area of insulin immunoreactive beta-cells in diabetic rats; however, hPTH treatment atone only led to a slightly increase in the insulin-immunoreactivity. These results suggest that NS might be used in a similar manner to insulin as a safe and effective therapy for diabetes and might be useful in the treatment of diabetic osteopenia. (c) 2007 Elsevier GmbH. All rights reserved.Öğe The expression of HER-2/neu (c-erbB2), survivin and cycline D1 in serous ovarian neoplasms: their correlation with clinicopathological variables(SPRINGER, 2014) Turan, Gulay; Usta, Ceyda Sancakli; Usta, Akin; Kanter, Mehmet; Tavli, Lema; Karacan, Meric; Celik, CetinOvarian cancer is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of HER-2/neu (c-erbB2), survivin and cycline D1 biomarkers in serous ovarian neoplasms and their correlations with clinicopathological variables in serous ovarian cancers. We analyzed pathological specimens of 62 patients with benign (n = 25), borderline (n = 14) and malignant (n = 23) serous ovarian neoplasms. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded specimens. Significantly more immunoreactivity with HER-2/neu was detected in malignant tumors (100 %) compared to borderline (78.6 %) and benign tumors (48 %) (P < 0.01). Survivin expression was significantly higher in malignant tumors (91.3 %) than those found in borderline (71.4 %) and benign tumors (24 %) (P < 0.001). Similarly, higher cyclin D1 expression was observed in malignant tumors (95.6 %) compared to borderline (85.7 %) and benign tumors (48 %) (P < 0.001). Expression of all biomarkers analyzed significantly and gradually increased from benign to borderline and borderline to malignant serous tumors. In terms of clinicopathological variables, only tumor grade was associated with the expression of all biomarkers others exhibited different correlations in serous ovarian cancers. The expressions of HER-2/neu (c-erbB2), survivin and cycline D1 are positively correlated with the malignant potential of serous ovarian neoplasms.Öğe Farklı Tespit Sıvılarının Sığır, Koyun ve Keçi Paratiroid Bezlerinin İnce Yapısı Üzerine Etkisi(Selçuk Üniversitesi, 1996) Kanter, MehmetTissue samples of parathyroid glands obtained from cattle, sheep and goat were immersed in aither 2.5% glutaraldehyde (GA), or in 1% glutaraldehyde and 2% formaldehyde (FA) followed by immersion in 1% osmium tetroxide (Os04). The effect of different bulters used for aldehydes and osmium tetroxide respectively, were tested in order to determine the optimal conditions for preservation of parathyroid cell morphology. Uniform (the subcellular components of these cells showed no damage due to fixation), light (light cytoplasmic matrix and the subcellular components were damaged to a variable extent due to fixation) and dark (dark cytoplasmic matrix and shrunken cell) cells were found in the parathyroid tissues of all animals. Parathyroid tissue fixed with aldehydes in the presence of Na/Kphosphate, Na-cacodylate or Hep es [ 4-(2-Hydroxyethyi)-1-Piperazinethan-Sulfonic acid] (with or without Ca2+ and Mg2+). and with osmium tetroxide in Na/K-phosphate or Na-cacodylate contained predominantly uniform. few light and dark cells. However, number of light cells lncreased in parathyroid tissue fixed with osmlum tetroxlde In Hepes. In addition to the increased light cells, number of multinuclear ce lls (the cells contained fragments of the plasma membrane and markedly dilated cisternae of the rough endoplasmic reticulum) also increased in parathyroid tlssues of sheep. The structure is batter preserved and particularly the membranes are batter visible in preparations fixed with a mixture of glutaraldehyde and formaldehyde than in those immersed only in glutaraldehyde. lt is concluded that the appearance of tour different cell types depended to a great extent on the bulters and 1 or fixatives used in the experiment. lt is also concludet that bulters played more important roles then fixatives in the occurrence of these cell types.Öğe Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in rats(ELSEVIER IRELAND LTD, 2006) Ocakci, Ayse; Kanter, Mehmet; Cabuk, Mehmet; Buyukbas, SadikObjectives: This study was evaluated to investigate the efficacy of caffeic acid phenethyl ester (CAPE), which is a natural honeybee product exhibits a spectrum of biological activities including anti-microbial, anti-inflammatory, antioxidant and anti-tumoral actions, on the prevention of stricture development after esophageal caustic injuries in the rat. Methods: Thirty healthy mate Wistar albino rats were utilized in this study. The rats were randomly allotted into one of three experimental groups: group A (sham) animals were uninjured. Caustic esophageal burn was created by applying 1 ml 37.5% NaOH to the distal esophagus. Group B rats were injured but untreated. Group C rats were injured and received CAPE (10 mu mol/kg/day i.p. for 28 days). Efficacy of the treatment was assessed by measuring the esophageal transit time, stenosis index, histopathologic damage score and biochemically by determining tissue hydroxyproline content, lipid peroxidation and antioxidant enzyme activities. Results: The esophageal. transit time, the stenosis index, histopathologic damage score and the hydroxyproline level were significantly increased in the untreated group compared with the sham and CAPE-treated groups. Treatment with CAPE decreased tissue hydroxyproline Levels, histological damage, and the stenosis index, but except the esophageal transit time. Caustic esophageal burn also increased the lipid peroxidation and decreased the antioxidant enzyme activities in the untreated group. CAPE treatments decreased the elevated lipid peroxidation and also increased the reduced antioxidant enzyme activities. In corrosive esophageal burn group with no treatment, the most consistent findings were degenerative changes and increased in submucosal collagen content, and the luminal narrowing. CAPE treatment protected esophagus. Nevertheless, there was the slight increase in submucosal collagen. Conclusions: It is concluded that CAPE has a preventive effect on the stricture development after esophageal caustic injuries in the rat. (C) 2006 Elsevier Ireland Ltd. All rights reserved.Öğe Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms(SPRINGER, 2016) Kanter, Mehmet; Turan, Gulay; Usta, Ceyda; Usta, Akin; Esen, H. Hasan; Tavli, Lema; Celik, CetinThe most prevalent malignant ovarian neoplasms are epithelial ovarian cancers which is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of survivin and cycline D1 biomarkers in mucinous ovarian neoplasms and their correlations with clinicopathological variables in mucinous ovarian cancers. We analyzed pathological specimens of 98 patients with benign (n = 34), borderline (n = 22) and malignant (n = 42) mucinous ovarian neoplasms. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded specimens. Immunohistochemical analysis revealed that survivin and cyclin D1 expressions were located primarily in the nucleus of ovarian tumor cells and relatively weaker cytoplasmic staining. Survivin expression was significantly higher in malignant tumors (88.1 %) than those found in borderline (18.2 %) and benign tumors (8.8 %) (p < 0.001). Similarly, higher cyclin D1 expression was observed in malignant tumors (100 %) compared to borderline (36.4 %) and benign tumors (5.9 %) (p < 0.001). Expression of all biomarkers analyzed significantly and gradually increased from benign to borderline and borderline to malignant mucinous tumors. In terms of clinicopathological variables, tumor grade, FIGO stage and lymph node methastasis were associated with the expression of both biomarkers. Whereas age exhibited no different correlations in mucinous ovarian cancers. The expressions of survivin and cycline D1 are positively correlated with the malignant potential of mucinous ovarian neoplasms.Öğe Tazı ve Sokak Köpekleri?nde Bulbus Olfaktoryusun Histomorfoloji?si? Üzeri?nde Karşılaştırmalı Bi?r Araştırma(Selçuk Üniversitesi, 1997 Ocak) Kanter, MehmetIn the present study, olfactory bulbs of greyhound and outdoor dogs were compared histologically. It was found that the olfactory bulbs of both species were constituted by accessory and main parts having the same layers (nerve, glomerular, eksternal pleksiform, mitral cell, internal pleksiform and granular cell). Nerve, glomerular and mitral cell layers were very wide and there were many glial cells in the last two layers in the olfactory bulbs of greyhound. However, in outdoor dog, these layers were very narrow and there were few mitral and glial cells. Differences in the smelling ability between greyhounds and outdoor dogs were thought to be depended on the histomorphological differences of their olfactory bulbs.
