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  • Küçük Resim
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    Does Prenatal Exposure to Diclofenac Sodium Affect the Total Number of Cerebellar Granule Cells in Male Juvenile and Adult Rats?
    (2012) Ekici, Fatih; Keskin, İlknur; Aslan, Hüseyin; Erişgin, Züleyha; Altunkaynak, Berrin Zühal; Gökçimen, Alpaslan; Odacı, Ersan; Kaplan, Süleyman
    A developing embryo is exposed to side effects of diclofenac sodium (DS), a commonly used non-steroidal anti-infl ammatory drug, since women may incidentally become pregnant while receiving DS therapy. Several adverse effects of DS have been clearly established. However, the effects of prenatal exposure to DS on the developing cerebellum especially are unclear for granular cells. In this study, we investigated the total number of granule cells in the cerebellum in control and DS-treated groups of male rats using the optical fractionator technique. DS (Voltaren, 75 mg/3 ml) in a dose of 1 mg/kg daily was intraperitoneally injected in the drug-treated group of pregnant rats beginning from the 5th day after mating during pregnancy for 15 days. Serum physiological at 1 ml/kg dose was injected in the control group of pregnant rats during the same period and the same way. Male offspring were obtained after delivery, and each group was divided two subgroups that were 4-weeks-old (4W-old) and 20-weeks-old (20W-old). Our results showed that there was no signifi cant difference not only between the 4W-old DS-treated rats and the 4W-old control group but also between 20W-old DS-treated rats and the 20W-old control group. These results suggest that the development of the granule cells in the male cerebellum may not be affected during either in the early or late life of an animal following administration of DS during the prenatal period. © 2012 OMU All rights reserved.
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    Öğe
    Quantification of nuclear volume of neurons in the medial hyperstriatum ventrale of three day-old chick brain using stereologic methods
    (1997) Erdinç, Nurhan; Kaplan, Süleyman
    Nuclear volume of neurons in the medial hyperstriatum ventrale (MHV), apart of three day-old chick brain that is concerned with learning and memory, was obtained by new stereological methods. Mean nuclear volume and coefficient of variation of the number distribution of nucleus volume was estimated by selector and point-sampled intercepts methods. In the MHV of forebrain of chick, of the same sex there is no difference between the nuclear volume of neurons in the left and right brain hemispheres. However the mean nuclear volume is significantly different between male (VV 1670, 32±0.04 SEM \1mm3) and female chicks (VV 1114,9±0.04 SEM mm3) with the present knowledge we could not interpret why the mean nuclear volume in the right and left MHV region of male chick forebrain is significantly bigger than females.