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Öğe Blunt chest trauma as a cause of acute myocardial infarction(TAYLOR & FRANCIS LTD, 2014) Kara, H.; Avcı, A.; Akıncı, M.; Değirmenci, S.; Bayır, Ayşegül; Ak, AhmetChest pain after thoracic trauma may be a symptom of cardiac injury or myocardial infarction. A 63-year-old healthy man had chest pain after blunt chest trauma in a motor vehicle accident. Chest computed tomography scan showed a displaced sternal fracture, lung contusion in the left upper lobe, atelectasis and consolidation in both lower lobes, and bilateral haemothorax. Electrocardiography showed ST elevation (2 mm) in leads II, III, and aVF and ST depression (2 mm) in leads I and aVL, consistent with acute inferior myocardial infarction. Urgent coronary angiography showed ostial occlusion of the right coronary artery. After the right coronary occlusion was passed with a guide wire, dissection of the right coronary artery was observed and treated with a balloon and stent to reestablish normal flow. This case emphasizes the importance of a high index of suspicion for coronary artery injury and myocardial infarction after blunt chest trauma.Öğe Cobalt(II) and Nickel(II) Transfer Through Charged Polysulfonated Cation Exchange Membranes(Academic Press Inc Elsevier Science, 2000) Ersoz, M.; Kara, H.The transport of Co(II) and Ni(II) ions through charged polysulfonated ion exchange membranes under Donnan dialysis conditions has been studied as a function of pH gradient at 25 degreesC. In the Donnan dialysis process, the membrane is bounded by two electrolyte solutions, the one side (donor phase) initially containing metal salts and the other H2SO4 with no external potential held applied. The transport of metal ions through membranes was correlated with the flux data as well as with estimated diffusion coefficients and was found to depend on the interaction between the fixed groups in the membrane and the metal ions. It was observed that the pH gradient influences the transport of metals and the flux of ions increases with H ion concentration in the receiver phase.Öğe The effects of CoQ10 on the erythrocyte and liver tissue cholinesterase, NO and MDA levels in the acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of melatonin on erythrocyte and brain cholinesterase, nitric oxide and MDA levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of melatonin on erythrocyte and renal tissue cholinesterase, nitric oxide and MDA levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of N-acetylcysteine on the erythrocyte and lung tissue cholinesterase, nitric oxide and malondialdehyde levels in acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning(SAGE PUBLICATIONS LTD, 2013) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.The aim of this study was to examine the effects of ubiquinone (CoQ10) on heart tissue and erythrocytes in acute organophosphate poisoning (AOP). A total of 20 rabbits were divided into three groups: sham (n = 8), pralidoxime (PAM) + atropine (n = 6), and CoQ10 + PAM + atropine (n = 6). Blood samples were taken from each test subject to measure the values of acetylcholinesterase (AChE), nitric oxide (NO), and malondialdehyde (MDA) in the plasma and erythrocyte before administration of 50 mg/kg dichlorvos by orogastric tube. Blood samples were then taken at 1, 12, and 24 h post-dichlorvos to determine plasma and erythrocyte levels of AChE, NO, and MDA. Sham group received no treatment. PAM + atropine group received 0.05 mg/kg atropine with repeated doses and PAM: first a 30-mg/kg intravenous (IV) bolus, then a 15-mg/kg IV bolus every 4 h. CoQ10 + PAM + atropine group received same dose PAM and atropine and a 50-mg bolus of IV CoQ10. Thoracotomy was performed in all the animals 24 h after poisoning and then heart tissue samples were obtained. At 12 and 24 h, erythrocyte AChE levels in the CoQ10 animals were considerably higher than those in PAM + atropine animals (p = 0.023 and 0.017, respectively). At 12 and 24 h, erythrocyte MDA and NO levels in CoQ10 animals were significantly lower than those in PAM + atropine animals (p < 0.05). Heart tissue AChE levels in CoQ10 animals were considerably higher than those of the sham and PAM + atropine animals (p = 0.001). Heart tissue MDA and NO levels of CoQ10 animals were significantly lower than those of the sham and PAM + atropine animals (p < 0.01). Treatment of AOP with CoQ10 + PAM + atropine in this animal model had a beneficial effect on both erythrocyte and heart tissue lipid peroxidation and AChE activity.Öğe The effects of vitamin E on the erythrocyte and heart tissue cholinesterase, NO and MDA levels in the acute organophosphate toxicity(ELSEVIER IRELAND LTD, 2011) Bayir, A.; Kara, H.; Koylu, O.; Kocabas, R.; Ak, A.[Abstract not Available]Öğe Evaluation of h beta D-1 and h beta D-2 Levels in Saliva of Patients with Oral Mucosal Diseases(UNIV WEST INDIES FACULTY MEDICAL SCIENCES, 2013) Kucukkolbasi, H.; Kucukkolbasi, S.; Ayyildiz, H. F.; Dursun, R.; Kara, H.Objective: This study aimed to determine a possible correlation between oral mucosal disease and salivary concentrations of the antimicrobial peptides human beta-defensin-1 (h beta D-1) and human beta-defensin-2 (h beta D-2). Method: The present work focussed on the establishment of a reversed phase-high performance liquid chromatography (RP-HPLC) procedure to quantify human beta-defensins (h beta D-1 and h beta D-2) in saliva samples of patients with oral diseases such as lichen planus (n = 10), Behcet (n = 10) and recurrent apthous stomatitis (n = 10). Results: Linear calibration range for h beta D-1 and h beta D-2 defensins was 1.67-200 mu g mL(-1) and 3.13 - 100 mu g mL(-1) with R-2 values of 0.9998 and 0.996, correspondingly. The concentration of beta-defensins in saliva was determined by comparing the peak areas of eluted h beta D-1 and h beta D-2 with that of their standards. The variation of the amount of beta-defensins was evaluated by comparisons of the results obtained from the patients with oral mucosal diseases before and after treatments and the control subjects. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.62 mu g mL(-1) and 5.39 mu g mL(-1) for h beta D-1 and 0.94 mu g mL(-1) and 3.13 mu g mL(-1) for h beta D-2, respectively. Conclusion: The salivary beta-defensin concentration was significantly higher in patients with oral mucosal diseases than in healthy volunteers; furthermore, in patients with oral mucosal diseases, the concentration was significantly higher before treatment than after treatment.Öğe Imipramine Treatment of Panic Disorder Patients With Frequent Sleep Panic(1999) Ağargün, Mehmet Yücel; Kara, H.; Çilli, A. SavaşObjective: The aim of this study was to examine the effectiveness of imipramine treatment in the panic disorder patients who had frequent sleep panic attacks as predominant clinical features. Method: Thirteen patients whose sleep panic attacks represented their primary complaint at the time of admission were given imipramine for an 8-week trial. Results: 150 mg/day imipramine treatment reduced the frequency and the severity of sleep panic attacks in patients. Conclusions: These findings suggest that imipramine is useful in the treatment of this subgroup patients of panic disorder.Öğe Pulmonary embolism severity index, age-based markers and evaluation in the emergency department(MANEY PUBLISHING, 2015) Kara, H.; Degirmenci, S.; Bayir, A.; Ak, A.Objectives: The purpose of this study was to assess the severity of pulmonary embolism in the emergency department using vital signs and age-based vital parameters and compare these parameters with pulmonary embolism severity index (PESI) score. Methods: Between January 2011 and October 2014, there were 284 patients diagnosed with pulmonary embolism in the Emergency Unit of Selcuk University Hospital. Patient records were reviewed retrospectively. The PESI scores were calculated, and patients were divided into high-and low-risk groups. Shock index (SI), age-based shock index (SIA), maximum heart rate (MHR), minpulse (MP) and pulse maximum index (PMI) were calculated. The association of these parameters with PESI was evaluated. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the association of risk and mortality with age-based markers. Results: There were 75 men (43%) in the 173 patients included in the study. The PESI classification showed 54 patients in the low-risk group and 119 patients in the high-risk group. Mortality was higher in the PESI high-risk group, and no deaths occurred in the low-risk group. Comparison of the age-based markers and PESI for patients who died or survived showed that AUC for PESI was 0.807, AUC for SI was 0.824 and AUC for SIA was 0.825. Conclusions: The SIA risk classification was more efficient than SI in pulmonary embolism patients who presented to the emergency unit. The SIA was more accurate than SI or PESI in predicting mortality.Öğe Sorption of Target Anions by Ligand Exchange(JOHN WILEY & SONS INC, 1998) Çengeloğlu, Y.; Mercimek, B.; Kara, H.; Ersöz, M.The sorption of anionic ligands such as I-, Br-, and SCN- onto diaminoethyl-sporopollenin (DAE-Sporopollenin) was investigated in both column and batch experiments at room temperature. The isotherm binding constants suggest that the resin is most efficient at the binding of I- compared with Br- or SCN-. The general ligand sorption affinity series observed was I- > Br- > SCN-. This ligand sorption could be described by considering the hydration of ions in the exchanger. The sorption behavior of the ligand exchanger and the possibilities of selectively removing and recovering ligands are discussed on the basis of their chemical and complexing properties.Öğe Use of Humic Acid-based Nanofibers for Dye Removal and Transport(IEEE, 2017) Ayyildiz, H. F.; Ozcan, F.; Ertul, S.; Kara, H.; Aygun, A.A highly efficient nanofibrous adsorbent was prepared by using a mixture of humic acid (HA) and polyacrylonitrile (PAN) in DMF via electrospinning process, and the obtained nanofibrous adsorbent (PAN-HA) was used in copper removal. Owing to the incorporation of functional groups of HA, PAN nanofiber was turned into a material (PAN-HA) exhibiting anionic and cationic dye transfer. The prepared nanofiber mat was found to exhibit a suitable morphology according to the results of scanning electron microscopy, SEM, images. In this study, the removal and transport of HA-doped PAN nanofibers at different ratios (0-100%) at different pH and concentrations of methyl oranj, congo red, rodamin B and navy blue are carried out in a special membrane system. The results were evaluated in the design expert program.
