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    Evaluation the early effects of single high dose radioiodine therapy on lacrimal gland function
    (IJRR-IRANIAN JOURNAL RADIATION RES, 2014) Gedik, G. K.; Gedik, S.; Koktekir, B. E.; Kebapcilar, L.; Kara, P. O.
    Background: The therapeutic administration of I-131 for thyroid remnant ablation and for metastases comes up with some adverse effects. This study was conducted to investigate whether single high dose radioiodine therapy affects lacrimal gland functions or not. Materials and Methods: Seventy-eight eyes of 39 patients, who were diagnosed as differentiated thyroid carcinoma, were objectively tested with Schiermer's test and tear film break-uptime test; before and 1 and 6 months after high dose (>= 3700 MBq) I-131 therapy. Results: The median values of pre-treatment Schiermer's test were 10.00 mm and 9.60 mm for right and lefteyes, respectively. At the post-treatment first and sixth months, no significant change was observed in the median values of Schiermer's test in both eyes (p= 0.189 and p= 0.085, respectively, Friedman test). The median values of pre-treatment tear film break-uptime test were 9.15 sn and 9.20 sn for right and lefteyes, respectively. The median values of post-treatment tear film break-uptimes reduced at first and sixth months and the difference between the pre-treatment and post-treatment values were significant in both eyes (p=0.020 and p=0.022 for right and lefteyes, respectively, Friedman test). Conclusion: Impairment of goblet cell function occurs early after administration of single high dose I-131 application. However, reduction in tear secretion from lacrimal gland is not observed.
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    Mercaptoacetyltriglycine Renal Scan for the Differential Diagnosis of Acute Tubular Necrosis and İnterstitial Nephritis Associated to Vancomycin
    (ELSEVIER DOYMA SL, 2012) Gedik, G. K.; Yılmaz, F.; Kaya, B.; Kara, P. O.; Sarı, O.
    The differential diagnosis of vancomycin associated renal toxicity includes acute tubular necrosis and interstitial nephritis. We report a case of vancomycin induced renal toxicity shown by Tc-99m mercaptoacetyltriglycine renal scan. Nephrotoxicity was evolved secondary to vancomycin used for treating a patient with meningitis. Tc-99m mercaptoacetyltriglycine renal scan may play a role in differentiation between acute tubular necrosis and tubulointerstitial nephritis of vancomycin associated renal toxicity and can facilitate the clinical decision making. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.
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    Splenic and Multiple Abdominal Metastases of Endometrial Carcinoma Detected with FDG-PET/CT
    (ELSEVIER SCIENCE INC, 2012) Kara, T.; Kara, P. O.; Gedik, G. K.; Sarı, O.
    A 58 year old female was referred for FDG-PET/CT for restaging of endometrial adenocarcinoma. For evaluation of treatment, no metastases were detected on FDG-PET/CT which was performed 18 months later after the surgery. During follow-up, FDG-PET/CT was performed 6 months later than the previous FDG-PET/CT for restaging. A lesion with increased metabolic activity (SUV max: 10.21) was detected at spleen which was not seen on previous FDG-PET/CT scan. The lesion was consistent with metastasis of endometrial carcinoma. Splenic metastasis of endometrial carcinoma is extremely rare. There are only 13 cases of splenic metastasis from endometrial carcinoma that reported in the literature before. There is only one splenic metastasis of endometrial carcinoma case reported in the literature which is imaged with FDG-PET. To best of our knowledge this is the first report of solitary splenic metastasis of endometrial carcinoma that is imaged with FDG-PET/CT.