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Öğe A. Axillarisden Ayrılan A. Brachialis Süperficialis(2000) Karabulut, Ahmet Kağan; Uysal, İsmihan İlknur; Ziylan, Taner; Murshıd, Khalil AwadhAmaç: A. axillarisden ayrılan a. brachialis süperficialis varyasyonunun değerlendirilmesi. Olgu sunumu: Anatomi Anabilim Dalı rutin laboratuvar diseksiyonları esnasında 42 yaşında bir erkek kadavrada a. axillarisin 2. costa üst seviyesinde ilk dalını verdikten sonra iki köke (a. brachialis süperficialis ve a. brachialis profunda ) ayrıldığı gözlendi. A. axillarisin 2. ve 3. dalı a. brachialis süperficialisden ayrılırken, diğer dalların ise a. brachialis profundadan çıktığı tespit edildi. A. brachialis profundadan tek bir kütük olarak ayrılan A. profunda brachii bulunamadı. Bunun yerine a. brachialis profundanın A. profunda brachii seyrine uyacak şekilde onun dallarını vererek sonyandığı tespit edildi. A. brachialis süperficialisin kolun distalinde a. collateralis ulnaris superior ve inferior dallarını verdikten sonra art. cubitiden geçen transvers eksenin yaklaşık 1,5-2 cm altında terminal dallarına (a.radialis ve a. ulnaris) ayrıldığı gözlendi. Sonuç: Bu vakada a. axillarisin nadir görülen bu varyasyonunun daha önce bildirilen benzer varyasyonlardan ayrılan özelliği, a. brachialis profundadan tek bir kütük olarak ayrılan a. profunda brachiinin saptanamamış olmasıdır. A. axillarisin varyasyonlarının bilinmesi, klinik uygulamalarda plastik cerrahlar, ortopedistler ve radyologlar açısından oldukça önemlidir.Öğe An anatomic study of the lateral femoral cutaneous nerve in human fetuses(2016) Fazlıoğulları, Zeliha; Uysal, İsmihan İlknur; Doğan, Nadire Ünver; Karabulut, Ahmet Kağan; Ziylan, TanerObjectives:The aim of the study was to determine the anatomic course of the lateral femoral cutaneous nerve (LFCN) andits branches in relation to certain anatomic landmarks in human fetuses. Methods: This study was performed on 50 thighs from 25 spontaneously aborted fetuses with no detectable malformations. The LFCN position was evaluated according to its relation to the anterior superior iliac spine and its distance from thefemoral nerve and femoral artery were measured along the inguinal ligament (IL). The relationship between the LFCN andfemoral nerve in the pelvic cavity was also evaluated. Results: The branching pattern of the nerve was classified according to number and branching location of the main trunkas: Type I, a single trunk; Type II, two trunks, Type III;: three trunks, and Type IV: LFCN branching above or behind the IL.Sub-types of the LFCN were determined in accordance with the number of branches of the main trunk. Up to four branches of the LFCN were found; two branches originating from a single trunk was the most common type (54%). The most common site of the LFCN was observed nearly adjacent to the anterior superior iliac spine. In 11 lower limbs, the femoral nervewas accompanying with the LFCN on its course in pelvic cavity. Conclusion:The results of this study on the morphological features and variations of the LFCN in fetuses provide understanding of its variability for further studies in the regionÖğe Brachial Plexus Variations in Human Fetuses(Lippincott Williams & Wilkins, 2003) Uysal, İsmihan İlknur; Şeker, Muzaffer; Karabulut, Ahmet Kağan; Büyükmumcu, Mustafa; Ziylan, TanerOBJECTIVE: We examined the anatomic variations of the brachial plexus (BP) in human fetuses. METHODS: This study was performed with 200 BPs from spontaneously aborted fetuses without detectable malformations. The plexuses were dissected, and the normal position and/or morphological variations of the BP were determined and photographed. RESULTS: There were no variations in 93 plexuses, and 107 plexuses were observed to have different variations. Morphological variations were observed more frequently among female fetuses and right sides. The BPs were composed mostly of the C5, C6, C7, and C8 nerves and the T1 nerve. (71.5%). A prefixed plexus was observed in 25.5% of cases, and a postfixed plexus was observed in 2.5% of cases. In one case (0.5%), the C4 and T2 nerves joined the formation. The inferior trunk was not formed in 9% of cases. The superior trunk was not formed in 1% of cases. In one plexus, the superior trunk was formed by the ventral rami of the C4 and C5 nerves. In one case, the inferior trunk was formed by the ventral rami of the T1 and T2 nerves. Division variations were observed most frequently. There were also variations in the terminal branches, such as the roots of the median nerve joining in the distal part of the arm (8.5%), the axillary nerve being separate from the posterior division of the superior trunk (2.5%), and a connection existing between the median and musculocutaneous nerves (1%). CONCLUSION: Knowledge of BP variations is important for surgeons who perform surgical procedures in the cervical and axillary regions.Öğe Communications Between the Palmar Digital Branches of the Median and Ulnar Nerves: A Study in Human Fetuses and a Review of the Literature(Wıley, 2010) Ünver Doğan, Nadire; Uysal, İsmihan İlknur; Karabulut, Ahmet Kağan; Şeker, Muzaffer; Ziylan, TanerIn this study, median nerves (MNs) and ulnar nerves (UNs) were dissected in 200 palmar sides of hands (left and right) of 100 (50 male, 50 female) spontaneously aborted fetuses with no detectable malformations. The fetuses, whose gestational ages ranged from 13 to 40 weeks, were dissected under an operating microscope. The MN divided first into a lateral ramus and a medial ramus and then formed a common digital nerve. The first common digital nerve trifurcated in all of the studied cases. The branching patterns were classified into two types (Type 1 and Type 2) based on the relationship with the flexor retinaculum (behind/distal of it). A communication branch between the UNs and MNs in the palmar surface of the hand was found in 59 hands (29.5%). The proper palmar digital nerves were numbered from p1 to p10, starting from the radial half of the thumb to the ulnar half of the little finger, and these nerves exhibited six types of variations. The present data obtained from human fetuses will aid in elucidating the developmental anatomy of the nervous system and provide hand surgeons with a more complete anatomical picture to help them to avoid iatrogenic injuries.Öğe Coronary Artery Variations and Median Artery in Turkish Cadaver Hearts(SINGAPORE MEDICAL ASSOC, 2010) Fazlıoğulları, Zeliha; Karabulut, Ahmet Kağan; Ünver Doğan, Nadire; Uysal, İsmihan İlknurIntroduction: This study examined the routes and variations of the left coronary artery (LCA), the right coronary artery (RCA), and their branches, as well as the frequency of a median artery in cadaver hearts. Methods: The hearts of 50 adult Turkish cadavers from various centres were dissected. Results: The LCAs branched out of the aortic sinus and had an average diameter of 4.44 +/-1.79 mm. They gave rise to two branches (bifurcation) in 46 percent, three branches (trifurcation) in 44 percent and four branches (quadrifurcation) in ten percent of the hearts. The median artery was identified in 27 hearts, with a mean diameter of 2.00 mm (standard deviation 0.67). The RCAs branched out from the right aortic sinus and had an average diameter of 3.32 +/-0.79 mm. The conus branch, classically known as a branch of the RCA, branched out from the RCA in 32 percent of the hearts and from the right aortic sinus in 68 percent. Right dominance was observed in 42 percent, left dominance in 14 percent, and equal dominance in 44 percent of the hearts. Myocardial bridges were found on the LCA branches in 22 of the 27 hearts in which the median artery existed. Conclusion: There is a close relationship between the existence of the median artery and myocardial bridges. This suggests that the median artery might be important in myocardial bridges, which exist in embryos but do not result in any clinical symptoms for many years in a large number of people.Öğe Evaluation of Uterine Artery Origins on Contrast-Enhanced Magnetic Resonance Images(Selçuk Üniversitesi, 2023 Ekim) Sevindik, Betül; Ünver Doğan, Nadire; Seçilmiş, Özlem; Uysal, Emine; Fazlıoğulları, Zeliha; Karabulut, Ahmet KağanBackground/Aims: The origin of the uterine artery varies widely. The branching patterns of the internal iliac artery are also quite variable. Branching of the internal iliac artery in different ways is important in pelvic surgery. In our study, fertile and infertile groups were created, and the arteries that gave rise to the uterine artery were examined. Methods: A total of 152 uterine arteries (n = 152) were evaluated retrospectively on 3D contrastenhanced magnetic resonance images. Based on the study of Gomez-Jorge, the types of origin of the uterine artery were obtained. With regards to the incidence of types, differences between the fertile and infertile groups were examined. Results: There was no statistically significant difference between the groups in terms of the incidence of origin types (p = 0.214). Based on the study of Gomez-Jorge, five different types of origins were obtained. The most common was type I (the uterine artery being the first branch of the inferior gluteal artery) origination. Conclusions: There are studies investigating the origin of the uterine artery in literature. We believe that our findings will also contribute to the body of knowledge available.Öğe Fötuslarda Büyüme ve Gelişmenin Ultrasonografi ve Disseksiyonla Elde Edilen Humerus Uzunlukları ile Değerlendirilmesi(2000) Karabulut, Ahmet Kağan; Köylüoğlu, Beytullah; Uysal, İsmihan İlknurBu çalışmada insan fötuslarında humerus uzunluğundaki değişikliklerin gerek fötal büyüme ve gelişmenin değerlendirilmesinde, gerekse gestasyonel yaşın (GY) tespitinde kullanılabilirliğinin hem ultrasonografi hem de disseksiyon metodu ile araştırılması planlandı. Rutin gebelik kontrolleri için başvuran komplikasyonsuz, morfolojik olarak fötal anomali saptanmayan, tek fötuslu 198 adet gebede 2. ve 3. trimestırlarda humerus uzunlukları ultrasonografik olarak değerlendirildi. GY 14-40 haftalar arasında değişmekte olup anneden alınan, kesin olarak ifade edilen son menstruasyon tarihine göre belirlendi. Ultrasonografik olarak ölçülen humerus uzunluğu ile standart yöntemlerle elde edilen biparietal çap (BPÇ), femur uzunluğu (FU), kafa çevresi, karın çevresi ve GY arasındaki ilişki araştırıldı. Ayrıca GY'ları 13- 40 hafta arasında değişen 100 adet abort fötusun humerusları diseke edilerek uzunlukları ölçülüp, GY ile ilişkisine bakıldı. Elde edilen sonuçlar linear regresyon ve korelasyon analiz yöntemi ile SPSS programında istatistiksel olarak değerlendirildi. Ultrasonografik humerus uzunluk ölçümleri ile GY (R2 0.93, P 0.001), FU (R2 0.97, P 0.001), BPÇ (R2 0.95, P 0.001), kafa çevresi (R2 0.95, P 0.001) ve karın çevresi (R2 0.94, P 0.001) arasında doğrusal ilişki saptandı. Buna ilave olarak humerus uzunlukları ile GY arasındaki ilişkinin 2. ve 3. trimestırlar arasında farklılık gösterip göstermediğinin araştırılması amacıyla fötuslar 2 gruba ayrıldı. 1. gruptaki (14-27 hafta) humerus uzunluk artış hızı daha fazla olup, bu dönemde humerus uzunluğu ile gestasyonel yaş arasındaki korelasyon katsayısı 0.95 iken daha sonraki dönem (28-40 hafta) için 0.87 olarak saptandı. Disseksiyonla eldeedilen bulgular ultrasonografi ile elde edilenlere benzer olup, humerus uzunluğu ile GY arasında doğrusal ilişki (R2 0.87) tespit edildi. Korelasyon katsayıları 2. trimestırda 0.92 iken 3. trimestırda 0.64 olarak bulundu. Ultrasonografi ile elde edilen Humerus uzunluğu dikkate alındığında gestasyonel yaş hesaplamasında GY 5.17 0.51 x Humerus uzunluğu formülü kullanılabileceği saptandı. Çalışmada elde edilen veriler humerus uzunluğu ile GY ve fötus büyümesinin diğer standart parametreleri arasında yüksek bir korelasyon olduğunu ve GY tespitinde humerus uzunluğunun bir tahmin aracı olarak kullanılabileceğini göstermektedir.Öğe Growth Promoting Effects of Human Placental Lactogen During Early Organogenesis: A Link to Insulin-Like Growth Factors(Wıley, 2001) Karabulut, Ahmet Kağan; Layfield, Robert; Pratten, Margaret K.Many maternally derived factors may be involved in the regulation of embryonic growth but the control mechanisms involved are poorly understood. Human placental lactogen (hPL) has been implicated in playing a role in the control of embryonic growth. Several investigators suggested that there may be a possible link between the effects of this hormone and insulin-like growth factors (IGFs). In order to determine the growth promoting potential of hPL and involvement of IGFs in the mechanism of action of the hormone, 9.5 d rat embryos were cultured in vitro for 48 h in depleted serum in the presence and absence of hPL with additional IGF antisera. The growth supporting capacity of the serum was reduced by removal of low molecular weight molecules by prolonged filtration of the serum using filters with a molecular weight exclusion of 30 kDa. Addition of hPL (3.2-25.6 ng/ml) to depleted serum significantly improved embryonic growth and development, suggesting that the developing embryo may utilise hPL. The presence of antisera against hPL, IGF-I and -II abolished the hPL-induced increase in the development in all parameters suggesting that there may be a possible link between the IGFs and the effects of hPL on rat embryonic development and this hormone may achieve its growth promoting effects via IGFs.Öğe Human Foetal Sacral Length Measurement for the Assessment of Foetal Growth and Development by Ultrasonography and Dissection(Blackwell Wissenschafts-Verlag Gmbh, 2001) Karabulut, Ahmet Kağan; Köylüoğlu, B.; Uysal, İlknurThis study investigated the value of prenatal ultrasonographic measurements of sacrum as a predictor of in utero development and gestational age (GA), and to make a comparison between the data obtained by ultrasonography and dissection. A prospective cross-sectional study of ultrasonography was conducted in 186 pregnant women with uneventful single pregnancies. GA ranged from 14 to 40 weeks. and the relationships of sacrum length (SL) with GA, femur length (FL), biparietal diameter (BPD), head circumference (HC) and abdominal circumference (AC) were evaluated. In addition, the sacral bones of 101 spontaneously aborted foetuses aged from 13 to 39 weeks were dissected and measured. The relationship of the results with GA was investigated. There was a linear relationship between the ultrasonographic measurements of the SL and the GA (R-2 = 0.93, P < 0.001), the FL (R-2 = 0.93, P < 0.001), the BPD (R-2 = 0.93, P < 0.001), the HC (R-2 = 0.92, P < 0.001) and the AC (R-2 = 0.90, P < 0.001). The rate of increase of SL was significantly higher before 28 weeks of gestation than in later pregnancy, with a correlation coefficient between SL and GA of 0.96 and 0.88, respectively. The SL measurements obtained by dissection were similar to those of ultrasonography. There was a linear relationship between the SL and the GA (R-2 = 0.96, P < 0.001) and the correlation coefficients between SL and GA were 0.97 before 28 weeks of gestation, and 0.94 in later weeks. In conclusion, this study demonstrates a high correlation between the SL, GA and other standard measurements of foetal growth, and suggests that SL measurement is a valuable predictor of GA in the foetuses with normal growth.Öğe Investigation and Review of Myocardial Bridges in Adult Cadaver Hearts and Angiographs(Springer France, 2010) Fazlıoğulları, Zeliha; Karabulut, Ahmet Kağan; Kayrak, Mehmet; Uysal, İsmihan İlknur; Ünver Doğan, Nadire; Altunkeser, Bülent BehlülPurpose We aimed to compare the myocardial bridges (MBs) both in the coronary angiography and cadavers. Morphological (length, thickness, deepness, the angle between the long axis of vessel and location) and angiographic properties (length, degree of systolic obstruction, frequency) of the MBs were evaluated in 50 adult cadaver hearts and in 1,321 cineangiograms. Myocardial bridges were observed in 32 of the cadaver hearts (64%) and 100 of cineangiograms (7.57%). It was observed that MBs caused significant coronary stenosis in 34 of 100 individuals leading to the prevalence of significant MB to be (2.5%) in angiography. The MBs that are above the left anterior descending artery in cadaver were classified as superficial MB (77.4%) and deep MB (22.6%). In cineangiogram, the average length of MB (MBL) was determined as 10.32 +/- A 4.62 mm. The presence of MB, MBL and degree of luminal narrowing were not associated with the age and gender. Deepness and thickness were a major determinant of significancy of systolic obstruction by MBs.Öğe Investigation of direct toxic and teratogenic effects of anticoagulants on rat embryonic development using in vitro culture method and genotoxicity assay(WILEY, 2006) Uysal, İsmihan İlknur; Karabulut, Ahmet Kağan; Özdemir, Kurtuluş; Aksoy, M.; Altunkeser, Bülent Behlül; Acar, HasanHeparin and low molecular weight heparins (LMWHs) are used to reduce the incidence of venous thromboembolism in pregnancy. Although, these agents have been shown to be safe when used during pregnancy, the studies about direct toxic and teratogenic effects of these drugs on embryonic development are limited. In this study, the effects of heparin and LMWHs on rat embryonic development were investigated by using in vitro embryo culture and micronucleus (MN) assay methods. Rat embryos were cultured in vitro in the presence of different concentrations of heparin (5-40 IU/ml), dalteparin (2.5-20 IU/ml), enoxaparin (25-100 mu g/ml) and nadroparin (1-4 IU/ml). Effects of anticoagulants on embryonic developmental parameters were compared and embryos were evaluated for the presence of any malformations. After culturing the embryos, classic MN assay was performed. Anticoagulants significantly decreased all growth and developmental parameters dose-dependently. Dalteparin and enoxaparin were found to cause more developmental toxicity than heparin and nadroparin. Along with haematoma in general, heparin and nadroparin caused maxillary deformity, situs inversus and oedema most frequently, while neural tube defects were observed with dalteparin and enoxaparin. All agents also significantly induced MN formation in rat embryonic blood cells. These results indicate the possible genotoxic effects of anticoagulant agents on the developing rat embryo when applied directly.Öğe Klorakinin rat embriyosu gelişimi ve morfolojik yapısı üzerine etkileri ve serbest radikallerin bu etkideki rolü(2004) Uysal, İsmihan İlknur; Karabulut, Ahmet Kağan; Şeker, Muzaffer; Gürbilek, MehmetAmaç: Bu çalışmada sıtmanın akut veya profilaktik tedavisinde kullanılan klorokinin memeli embriyosunun büyüme, gelişme ve morfolojik yapısı üzerine etkileri ve serbest radikallerin bu etkilerdeki rolünün in vitro rat embriyosu kültürü tekniği ve biyokimyasal metodlar kullanılarak araştırılması amaçlandı. Yöntem: Selçuk Üniversitesi Deneysel Tıp Araştırma ve Uygulama Merkezi hayvan laboratuvarından elde edilen ratlardan gebeliklerinin 9.5’uncu gününde disseke edilerek çıkartılan embriyoların rat serumu içerisinde 48 saat süreyle kültürü yapıldı. Kültür ortamı olarak; kontrol grubu için normal rat serumu kullanılırken, deney grupları için ise rat serumuna 0.25 ve 0.50 mg/ml dozlarında klorakin ilave edildi. Klorakinin toksik etkisinin tüm parametreleri etkilediği dozları ile birlikte antioksidan superoksid dismutaz kültür ortamına ilave edildi. Her bir deneysel ortam için 10 embriyo kullanıldı. Klorakinin rat embriyolarının gelişim parametreleri olan; total morfolojik skor, yolk salk çapı, tepe-kıç mesafesi, somit sayısı, embriyo ve yolk salk protein içerikleri üzerine doz bağımlı etkileri, morfolojik ve biyokimyasal yöntemlerle karşılaştırıldı. Embriyolarda meydana gelen malformasyonlar değerlendirildi. Bulgular: Kontrol embriyoları ile karşılaştırıldığında klorakinin doz bağımlı olarak bütün gelişimsel parametreleri gerilettiği ve genel morfolojide bozukluklara sebep olduğu gözlendi. Bu anomaliler arasında fleksiyon deformitesi, nöral tüp açıklığı, optik ve otik deformiteler ön planda idi. Kültür ortamlarına klorakin ile birlikte superoksid dismutaz eklendiğinde klorakinin etkilerinin değişmediği gözlendi. Sonuç: Klorakinin organogenez dönemindeki rat embriyoları üzerine doz bağımlı gelişimsel toksisiteye sebep olduğu ve bu etkilerde serbest oksijen radikallerinin rol oynamadığı belirlendi.Öğe Kolda nervus medianus’un bir oluşum varyasyonu(2011) Fazlıoğulları, Zeliha; Ulusoy, Mahinur; Ünver, Nadire Doğan; Yılmaz, Mehmet Tuğrul; Karabulut, Ahmet KağanSelçuk Üniversitesi Meram Tıp Fakültesi Anatomi Anabilim Dalı’nda rutin öğrenci diseksiyonları sırasında, 67 yaşındaki erkek kadavrada n. media- nus varyasyonuna rastlandı. N. medianus kolun proksimalinde plexus brachialis’ten gelen dallarla normal olarak oluşmaktaydı. Kolun ortasında sinire fasciculus lateralis’ten gelen bir bağlantı dalının katıldığı tespit edildi. Radix lateralis nervi mediani ayrıldıktan sonra fasciculus lateralis’in ikiye ayrıldığı ve her iki dalın da musculus coracobrachialis’i deldiği gözlendi. Periferik sinir sisteminin anatomik varyasyonlarının bilinmesinin klinik nörofizyolojinin doğru yorumlanmasında ve farklı klinik bulguların açıklanmasında yararlı olacağı düşüncesindeyiz.Öğe Labelling of Rat Endothelial Cells With Antibodies to vWF, RECA-1, PECAM-1, ICAM-1, OX-43 and ZO-1(2002) Ülger, Harun; Karabulut, Ahmet Kağan; Pratten, M.K.Labelling with endothelium specific monoclonal antibodies, von Willebrand Factor (vWF), rat endothelial cell antigen-1 (RECA-1), platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), OX-43 and zonula occludentes-1 (ZO-1), was investigated in cryostat sections of vessels from rats of different ages using a confocal microscope. The results showed that labelling of the vWF was positive in endothelial cells from adult, fetal and different ages of embryonic rat. Labelling with RECA-1 was weakly positive in adult rat aorta and lung endothelial cells but not in embryonic yolk sac endothelial cells. Labelling using PECAM-1, ICAM-1 and OX-43 was negative in both adult and embryonic endothelial cells. ZO-1 showed positive but very weak reactivity in embryonic yolk sac endothelial cells. The expression of vWF on vessels from adult and 19.5-day fetal tissues was strongly positive. However, the expression of vWF in embryonic endothelial cells was dependent on the gestational age. While the 11.5-day yolk sac vessels stained weakly, staining gradually increased in 13.5-, 15.5- and 17.5-day-old yolk sac vessels. The results suggest that vWF is a reliable endothelial cell marker in rat vascular endothelial cells, including both fetal and embryonic stages.Öğe Maxillary-to-petrous Internal Carotid Artery Bypass: an Anatomical Feasibility Study(SPRINGER-VERLAG, 2003) Büyükmumcu, Mustafa; Üstün, ME; Seker, M; Karabulut, Ahmet Kağan; Uysal, YYThe possibility for maxillary artery (MA) to petrous internal carotid artery (ICA) bypass was investigated. Five adult cadavers were dissected bilaterally. After zygomatic arch osteotomy, the coronoid process was sectioned at its base. An extensive infratemporal craniotomy was performed at the level of foramina ovale, rotundum and spinosum. The petrous portion of the ICA was exposed by drilling away the floor of the middle fossa, posterior to the foramen ovale and medial to the foramen spinosum. The MA was identified medial to the infratemporal crest and was followed in the pterygopalatine fossa, then transected at the origin of the infraorbital artery. The MA graft was brought posteromedially to reach the petrous ICA. The mean caliber of the MA before the origin of the infraorbital artery was 2.54 +/- 0.31 mm, 2.76 +/- 0.14 mm at the site of anastomosis, and 3.46 +/- 0.32 mm after giving off the middle meningeal artery. The average length of the MA between the middle meningeal artery and the infraorbital artery was 43.4 +/- 2.35 mm, and up to the site of anastomosis was 37.64 +/- 1.68 mm. We conclude that the length and diameter of the MA are sufficient for a tension-free anastomosis between MA and petrous ICA, and such a procedure could be used in the treatment of patients with tumors of the infratemporal fossa invading the high cervical ICA.Öğe Morphometric Evaluation of Thoracic Vertebrae Using Multidetector Computed Tomography in Patients with Scoliosis(Selçuk Üniversitesi, 2023 Ekim) Tatar, Mehmet Cengiz; Karabulut, Ahmet Kağan; Öztürk, Mehmet; Güleç, Ali; Fazlıoğulları, Zeliha; Ünver Doğan, NadireAim: Many people have congenital and acquired deformities associated with the vertebral column. Vertebral surgery is practiced in cases like scoliosis, traffic accidents, falling down from height, cancer, and disc hernia. We aimed to reduce morbidity and mortality by creating alternative predictions for surgery and treatment with the findings and results we obtained in our study in patients with scoliosis. Methods: Patients with scoliosis (eight male, eight female) who underwent thoracic vertebrae imaging by multidetector computed tomography at Selcuk University Faculty of Medicine between 2013 and 2017 and who were not operated and those without scoliosis (eight male and nine female) who underwent imaging for other reasons were retrospectively evaluated. The group aged >15 years was created in a similar way. Similarly, groups with thoracic X-ray and tomography were created; Cobb angles and the width, height, and distance between the dorsal tips of the transverse process were measured in 12 thoracic vertebrae. Lateral distances from the midline junction of the right lamina of vertebra to the lateral of the right transverse process and pedicle of vertebra junction were measured; measurements were repeated for the left side and recorded. Measurements were made in 780 thoracic vertebrae. Results: Mean Cobb angle of 8 in 10–14-year-old male patients with thoracic scoliosis was 30.9° and mean age was 13 years. Mean Cobb angle of 8 in 10–14-year-old female patients with thoracic scoliosis was 32.72° and the mean age was 12.75 years. Conclusion: Our findings will help for manufacturers create personalized screws and plates, and help surgeons make operational choices.Öğe Nerium oleander'in liyofilize sıvı distilatının rat embriyoları gelişimi üzerine toksik ve teratojen etkilerinin in vitro kültür ortamında araştırılması(2014) Karabulut, Ahmet Kağan; Uysal, İsmihan İlknur; Baş, Ahmet Levent; Doğan, Nadire Ünver; Fazlıoğulları, Zeliha; Acar, HasanAmaç: Nerium oleander, her mevsimde yeşil kalan bir çalı türüdür. Halk arasında antidiabetik, antilipidemik ve geniş spektrumlu bir ilaç olarak kullanılır. Bu çalışmada Nerium oleander sıvı distilatının kültür ortamında gelişen rat embriyolarına etkilerinin araştırılması planlandı. Gereç ve yöntem: 9,5 günlük rat embriyoları, değişik konsantrasyonlarda (0.2 - 8 mg/ml) Nerium oleander ilave edilen rat serumunda 48 saat kültüre edildi. Her bir konsantrasyon için en az 10 embriyo kullanıldı. İlacın sıvı distilatı hidrodistilasyon metodu ile elde edildi. Nerium oleander'in toplam morfolojik skor, yolk sak çapı, tepe-kıç mesafesi ve somit sayısı gibi embriyonik gelişimsel parametreler üzerine doz bağımlı etkileri morfolojik metod ile karşılaştırıldı. Embriyolar malformasyonlar bakımından da değerlendirildi. İlacın genotoksisitesi DNA fragmentasyon metodu ile değerlendirildi. Bulgular: Değişik konsantrasyonlardaki Nerium oleander ilavesi ile kültüre edilen embriyolar kontrol grubu ile karşılaştırıldığında ilacın herhangi bir büyüme geriliği ya da malformasyona sebep olmadığı gözlendi. Sonuç: Bu sonuçlar Nerium oleander'in gebelikte, gelişen embriyo üzerine negatif etkisi olmadığını göstermiştir. Ancak bu veriler ileri in vivo deneyler ve hücre hattı çalışmaları ile desteklenmelidir.Öğe Sağ arkus aorta ve ayna görüntüsü dallanması: Bir olgu sunumu(2013) Kıvrak, Ali Sami; Koplay, Mustafa; Ünver, Nadire Doğan; Karabulut, Ahmet Kağan; Fazlıoğulları, ZelihaArkus aorta varyasyonları disfaji ve stridor gibi klinik belirtiler veebildiği gibi tamamen rastlantısal olarak da tespit edilebilir. Bu varyasyonlar radyolojik incelemeler ve cerrahi operasyonlar sırasında karı?ıklıklara yol açabildiği için anatomistler, radyologlar ve cerrahlar tarafından bilinmesi gereklidir. Bu yazıda, 50 ya?ındakbir erkeğin göğüs bilgisayarlı tomografisi görüntüsünde izlenen sağ arkus aort ve ayna görüntüsü dallanması sunulmaktadır. Sağ aortik arkın üçlü anomali görüntüsü; solda truncus brachiocephalicus varlığı, sağda truncus brachiocephalicus yokluğu ve sağ araftaki arterlerin önce a. carotis communis dextra daha sona a. subclavia dextra olmak üzere ayrı ayrı orijin almalarından olu?maktaydı.Öğe Saphenous Vein Graft for Bypass of the Maxillary to Supraclinoid Internal Carotid Artery: An Anatomical Short Study(SPRINGER-VERLAG, 2001) Karabulut, Ahmet Kağan; Üstün, Mehmet Erkan; Uysal, İsmihan İlknur; Salbacak, AhmetThe use of a saphenous vein graft for bypass of the maxillary artery (MA) to the supraclinoid internal carotid artery (ICA) in internal! carotid: occlusions is investigated. Five adult cadaver sides were used. Dissection required zygpmatic arch osteotomy and a pterional craniotomy with extensive removal of the floor of the middle cranial, fossa. The MA was found easily media[ to infratemporal crest. The clinoidal segment of the ICA was exposed with the removal of the anterior clinoid process intradurally. The bypass graft was 4 to 5 cm long and was sutured end-to-end to the MA and end-to-side to: the supraclinoid ICA. When high blood flow is needed in cases with ICA occlusion, such a bypass may be an alternative to superficial temporal (STA)-to-middle cerebral artery (MCA) bypass as well as to common carotid-to-MCA or-ICA bypass, which needs a long vein graft. This type of bypass will provide the opportunity to clip the ICA proximal to the origin of ophthalmic artery, which may inhibit distal embolization.Öğe Tip B Kesintili Arkus Aorta: Olgu Sunumu(Selçuk Üniversitesi, 2019 Ocak) Fazlıoğulları, Zeliha; Doğan, Nadire Ünver; Sevindik, Betül; Seher, Nusret; Karabulut, Ahmet KağanKesintili arkus aorta nadir rastlanan, fatal seyirli konjenital kardiyak bir anomali olup, aorta ascendens ile aorta descendens arasındaki bir segmentte atrezinin olması şeklinde tanımlanır ve %98 oranında diğer kardiovasküler anomalilerle birlikte bulunur. Üç tipi mevcuttur. Tip A’ da kesinti, a. subclavia sinistra’nın distalindedir. Tip B’de, a. carotis communis sinistra ile a. subclavia sinistra, tip C’de, a. carotis communis sinistra ile a. carotis communis dextra arasındadır. Selçuk Üniversitesi pediatrik kardiyoloji kliniğine başvuran postnatal 5. gününde bir erkek bebeğin çekilen ekokardiyografisinde; truncus brachiocephalicus’un distalinden itibaren tip B kesintili arkus aorta, ventriküler septal defekt, biküspit aorta, patent ductus arteriosus, atrial septal defekt, annulus aorticus hipoplazisi tespit edildi. Bilgisayarlı tomografi anjiyografisinde ise, a. carotis communis sinistra ile a. subclavia sinistra arasında bağlantı olmadığı görüldü. Bu vakada, arcus aorta anomalisi ve eşlik eden diğer kardiovasküler anomalilerin erken tanı ve tedavisinde radyolojik görüntüleme yöntemlerinin önemi vurgulanmaktadır.
