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    Türkiye'de yetişen Haplophyllum sahinii o.Tugay & D.Ulukus ve H. vulcanıcum Boiss. & Heldr. türlerinin tirozinaz ve asetilkolinesteraz inhibitör etkileri üzerine araştırmalar
    (Selçuk Üniversitesi Fen Bilimleri Enstitüsü, 2018) Karahisar, Esengül; Tugay, Osman; Orhan, İlkay Erdoğan
    The Haplophyllum species belonging to the family of Rutaceae, known as 'Citrus' in our country, are important medicinal and aromatic plants. The Haplopyhllum genus has a total of 18 taxa, of which 10 are endemic to Turkey. The traditional use of Haplopyhllum species in the treatment of herpes, warts, stomach pain, erysipelas, dental pain, skin diseases and testicular cancer in Saudi Arabia and Iran in antipyretic and tumor treatment in Mongolian and Sudanese folk medicine. Alzheimer's disease (AD) is a progressive and neurodegenerative disease that affects the elderly population in particular. The drug group, which acts by the inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes acetylcholine, is now the most common symptomatic treatment option because it has been found that the neurotransmitter called acetylcholine is missing in the brains of AD patients. The search for safe and effective tyrosinase inhibitors, which have been shown as a new target in the treatment of Parkinson's disease and which can also be used for hyperpigmentation therapy, skin whitening, stain removal, have gained importance in recent years. Within this thesis project, inhibitory effects of the ethanolic extracts prepared from different parts of the endemic species, e.g. Haplophyllum sahinii O. Tugay & D. Ulukus and Haplophyllum vulcanicum Boiss. & Heldr. species grown in Turkey against AChE and butyrylcholinesterase (BChE) associated with AD as well as tyrosinase (TYR) were investigated by using ELISA microplate reader at 200 µg mL-1 concentration. Although the extracts showed moderate to significant inhibition towards BChE showed a high inhibition to TYR. Enzyme inhibitory effect of the aforementioned plant species against AChE, BChE, and TYR is reported for the first time in this thesis.