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    Comparison of traditional risk factors, angiographic findings, and in-hospital mortality between smoking and nonsmoking turkish men and women with acute myocardial infarction
    (2010) Aygül, Nazif; Özdemir, Kurtuluş; Abacı, Adnan; Aygül, Meryem Ülkü; Düzenli, Mehmet Akif; Yazıcı, Hüseyin Uğur; Özdoğru, İbrahim; Karakaya, Ekrem
    Background: The prevalence of smoking is high in Turkey. However, there are no data available evaluating the differences between smokers and nonsmokers according to their sex in patients with acute myocardial infarction (AMI) in Turkey. Hypothesis: The aim of the study was to determine the prevalence of smoking and its relationship to age, localization, and extension of coronary heart disease (CHD), and other risk factors in Turkish men and women with first AMI. Methods: This study included, 1502 patients with first AMI from 3 different cities in Turkey. The baseline characteristics and traditional risk factors for CHD, Coronary angiographic results, and in-hospital outcome were recorded. Results: The proportion ofmale smokers was significantly higher than that ofwomen (68%vs 18%, P < 0.001). Smokers were younger by almost a decade than nonsmokers (P < 0.001). Male nonsmokers were younger than females; however, the mean age of first AMI was similar in male and female smokers. In both genders, prevalence of hypertension and diabetes mellitus was significantly lower in smokers than in nonsmokers (P < 0.001). Smokers had lessmultivessel disease andless comorbidity as compared to nonsmokers. Although the in-hospital mortality rate was lower in smokers, smoking status was not an independent predictor of mortality. Conclusions: Smoking, by decreasing the age of first AMI in women, offsets the age difference in first AMI betweenmen and women. The mean age of first AMI is lower in Turkey than most European countries due to a high percentage of smoking. © 2010 Wiley Periodicals, Inc.
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    Does Estimated Glomerular Filtration Rate Have an Effect on Left Ventricular Function after ST-Elevation Myocardial Infarction?
    (WILEY, 2014) Sonmez, Osman; Vatankulu, Mehmet A.; Tasal, Abdurrahman; Bacaksiz, Ahmet; Ayhan, Selim; Yazici, Huseyin U.; Karakaya, Ekrem
    ObjectivesLittle is known about whether estimated glomerular filtration rates (eGFR) affect left ventricular (LV) function and gain benefit with antiremodeling treatment in patients with ST-elevation myocardial infarction (STEMI). We investigated the effect of eGFR on LV function using tissue Doppler imaging (TDI) parameters. In addition, we sought to evaluate the antiremodeling effect of standard treatment at follow-up in patients with renal insufficiency (RI) after STEMI. Methods and ResultsA retrospective analysis of 579 patients with STEMI was performed. Patients were divided into 3 groups according to eGFR (Group 1: eGFR>90mL/min per 1.73m(2); Group 2: eGFR=60-89mL/min per 1.73m(2); Group 3: eGFR<60mL/min per 1.73m(2)). Conventional echocardiography and TDI were performed within 48-72hours after STEMI and at 6-month follow-up. The mean left ventricular ejection fraction (LVEF) was significantly lower in Group 3 than in Group 1 (P=0.021). The mean peak systolic velocity (Sm) was significantly lower in Group 3 than in Group 1 and Group 2 (P=0.002 and 0.006, respectively). The estimated GFR had a linear association with Sm and LVEF (P=0.001, r=0.161; P=0.005, r=0.132, respectively). Multivariate analysis showed that an eGFR<60mL/min per 1.73m(2) was an independent predictor of lower Sm and in-hospital mortality. In addition, an antiremodeling effect of standard treatment was seen in all groups at 6-month follow-up. ConclusionsEstimated glomerular filtration rate of <60mL/min per 1.73m(2) was associated with lower LV function after STEMI, and may gain an antiremodeling effect with standard treatment at follow-up.