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    Phototherapy causes a transient DNA damage in jaundiced newborns
    (INFORMA HEALTHCARE, 2013) Kahveci, Hasan; Dogan, Hasan; Karaman, Ali; Caner, Ibrahim; Tastekin, Ayhan; Ikbal, Mevlit
    In this study, we aimed to clarify the following questions: 1) Does phototherapy (PT) cause genotoxicity in full-term newborn babies undergoing PT as a result of neonatal jaundice?, 2) if genotoxic effect occurs, is there any relationship between the duration of PT and genotoxicity?, and 3) is genotoxic effect temporary or not? The frequency of sister chromatid exchange (SCE) was determined in jaundiced newborns before, during, and after phototherapy, then determined again in childhood (approximately 3.5 years old). Mean frequency of SCE of 22 full-term jaundiced babies significantly increased during the PT procedure and in every single day, compared to the previous day, in comparison to the pre-PT basal value (6.20 +/- 0.57;); mean SCE frequencies at 24, 48, 72, and 96 hours were 7.75 +/- 0.40, 8.16 +/- 0.47, 8.50 +/- 0.40, and 9.36 +/- 0.55, respectively (all P-values < 0.01). In childhood, no significant difference was found between the mean SCE value (4.9 +/- 0.9) of 20 of 22 children, who received PT in the neonatal period, and the mean SCE value (4.7 +/- 0.6) of 20 coevaluated healthy children (P = 0.40). This study demonstrates that the negative effect of PT on SCE is a temporary effect.
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    Rapid canine distalization through segmental alveolar distraction osteogenesis
    (E H ANGLE EDUCATION RESEARCH FOUNDATION, INC, 2007) Sukurica, Yusuf; Karaman, Ali; Gurel, Hakan Gurcan; Dolanmaz, Dogan
    Objective: The objectives of this study were to achieve rapid canine distalization by segmental alveolar distraction method in first premolar extraction cases, to examine the changes in the periodontal tissues surrounding canines, to evaluate the displacement of the canine and first molar teeth, to assess the effects of the procedure on the pulpal vitality of the canines, and to determine the amount of root resorption in retracted canines. Materials and Methods: The sample of the study consisted of 20 teeth in eight patients (four females and four males, mean age 18.5 years). Pre- and posttreatment dental casts, panoramic radiographs, and standard periapical radiographs were taken from all patients. An electrical vitality test was applied before and after the distraction procedure and during the follow-up period (6 months after the completion of the procedure). In addition, six periodontal indices were used to examine the health of the periodontal tissues. Results: The distraction procedure was completed in 12 to 28 days (mean 14.65 +/- 3.49). The anchorage loss ranged from 0 to 3 mm (mean 1.2 +/- 0.83). The distal displacement of the canines ranged from 3 to 8 mm (mean 5.35 +/- 1.22). The canines showed a mean of 9.1 degrees distal tipping, whereas there was no statistically significant change in the axial inclinations of first molars after distraction. Conclusion: We believe that rapid canine distalization by segmental distraction osteogenesis will become a routine protocol and a popular method among orthodontic applications.