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    Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure
    (ELSEVIER SCI LTD, 2005) Ortatatli, M; Oguz, H; Hatipoglu, F; Karaman, M
    This study was conducted to evaluate the pathological changes in broilers fed a diet containing low-levels of aflatoxin (AF) and clinoptilolite (CLI) until 42 days of age. A total of 576 one-day-old Ross-308 type broiler chicks were treated with varying levels of AF and CLI (15 g kg(-1)). The gross and histopathological changes in the liver, kidneys, spleen, thymus and bursa of Fabricius were investigated and relative organ weights were calculated. Compared to controls, significant changes (P < 0.05), such as slight to moderate hydropic degeneration and/or fatty change (8 cases of 10), bile-duct hyperplasia (7 of 10) and periportal fibrosis (5 of 10), were found in chicks fed 100 ppb AF-containing diet. No gross-pathological changes were observed in any treatments. The addition of CLI to the 100 ppb AF-containing diet significantly decreased the number of affected broilers and/or the severity of lesions (hydropic degeneration and bile-duct hyperplasia) in the livers (P < 0.05). The addition of CLI to the AF-free diet did not produce any significant lesions compared with the controls. (C) 2004 Published by Elsevier Ltd.
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    Evaluation of the detoxifying effect of yeast glucomannan on aflatoxicosis in broilers as assessed by gross examination and histopathology
    (TAYLOR & FRANCIS LTD, 2005) Karaman, M; Basmacioglu, H; Ortatatli, M; Oguz, H
    1. We evaluated the efficacy of yeast glucomannan ( Mycosorb(R)), incorporated into the diet at 0.5 and 1 g/ kg, in reducing the detrimental effects of 2mg aflatoxin/ kg diet on growing broiler chicks from 1 to 21 d of age. 2. A total of 240 male broiler chicks ( Ross- 308) was divided into 6 treatment groups [ Control, Aflatoxin ( AF), Yeast glucomannan ( YG; 0.5 g/ kg), AF plus YG ( 0.5 g/ kg), YG ( 1 g/ kg), and AF plus YG ( 1 g/ kg)]. 3. Ten chicks from each of the 6 groups were slaughtered and pathological examinations were performed on the liver, bursa of Fabricius, thymus, spleen and kidney. 4. The aflatoxin treatment caused moderate to severe hydropic/ fatty degeneration in the hepatocytes of the liver and the tubular epithelium of the kidneys, and follicular depletion in the bursa of Fabricius, thymus and spleen. 5. Yeast glucomannan added to the aflatoxin- containing diet at 0.5 and 1 g/ kg diminished the severity of pathological changes, slightly and moderately, respectively. The number of affected organs was also reduced in the group given 1 g/ kg yeast glucomannan, compared to the aflatoxin group. 6. These results show that yeast glucomannan effectively diminished the adverse effects of aflatoxin on the pathological changes and that the higher concentration of yeast glucomannan ( 1 g/ kg) was more effective than the lower concentration ( 0.5 g/ kg) and itself had no adverse effect.
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    Malignant fibrous histiocytoma in a dog: a case report
    (CZECH ACADEMY AGRICULTURAL SCIENCES, 2005) Kiran, MM; Karaman, M; Hatipoglu, F; Koc, Y
    In this report, a case of malignant fibrous histiocytoma involving skin, lungs, kidneys, pancreas and mediastinal lymph node was described. Microscopically, the tumor classified as storiform-pleomorphic type malignant fibrous histiocytoma.