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Öğe Assessment of Left Ventricular Systolic and Diastolic Function With Conventional and Tissue Doppler Echocardiography Imaging Techniques in Patients Administered Tyrosine Kinase Inhibitor(2012) Alihanoğlu, Yusuf İzzettin; Kaya, Zeynettin; Arı, Hatem; Karaarslan, Şükrü; Yıldız, Bekir Serhat; Karanfil, Mustafa; Yazıcı, Mehmet; Börüban, Melih Cem; Özdemir, Kurtuluş; Ülgen, Mustafa SıddıkObjectives: The aim of this study was to use echocardiographic techniques to determine the possible cardiotoxic effects of low molecular weight tyrosine-kinase inhibitors (TKI) in patients receiving the therapy for the first time. Study design: Thirty patients (17 females; 13 males; mean age 49±16; range 22 to 76 years) who met the exclusion criteria and were diagnosed as having malignancy were enrolled. All patients underwent conventional echocardiography and tissue Doppler imaging (TDI) prior to the treatment. The conventional echocardiogram was repeated 2 months later as the patients were concurrently receiving therapy. Myocardial Performance Index was obtained by conventional echocardiography and by TDI techniques to evaluate left ventricular systolic and diastolic function. Results: Statistically significant increase occurred in mean left ventricle (LV) end-systolic volume. However, there was significant decrease in both mean LV ejection fraction and LV stroke volume values (64±3, 62±4, p=0.000 and 67±13, 61±13, p=0.000, respectively). Anterior wall Em/Am ratio measured by using the TDI technique was significantly decreased at the end of two months (0.99±0.49, 0.90±0.41, p=0.03). In addition, decreases were determined in Sm values obtained from all of four LV walls and also in mean Sm value, but this decrease was significant only for the lateral wall Sm measurement (12.8±2.9, 11.6±2.3, p=0.004). Conclusion: Tyrosine-kinase inhibitors therapy can be administered safely to patients without predisposing factors for cardiotoxicity in short treatment intervals, and low molecular TKIs may cause subtle or clinically significant cardiotoxicity following the treatment period even in patients without predisposing factors for cardiotoxicity, so clinicians should consider this possibility.Öğe A Rare Varieties of Diabetic Autonomic Neuropathy: Carotid Sinus Hypersensitivity, Case Report(2016) Kaya, Ahmet; Turan, Elif; Turan, Yaşar; Karanfil, Mustafa; Kulaksızoglu, Mustafa; Güney, FigenCarotid sinus hypersensitivity is a common cause of fainting and falls in older adults and can be diagnosed by carotid sinus massage. We have presented a 67-year-old diabetic male patient who was admitted to our clinic because of hyperglycemia. In thyroid examination, clouding of consciousness occurred with unilateral palpation. Documented 4,8 seconds and undocumented 7 seconds of asystole were detected during the carotid sinus massage. An implantable cardioverter defibrillator was implanted in our patient. Carotid sinus hypersensitivity should be kept in mind in the examination of diabetic patients.Öğe The relationship between white coat hypertension and sleep quality(SPRINGER JAPAN KK, 2014) Kaya, Zeynettin; Kayrak, Mehmet; Demir, Kenan; Gunduz, Mehmet; Alibaşiç, Hayruddin; Karanfil, Mustafa; Akıllı, HakanImpaired sleep quality is frequently associated with hypertension. The present study aims to examine self-reported sleep quality of patients with white coat hypertension. A total of 74 subjects who were evaluated in a cardiology outpatient clinic, including 39 normotensive subjects and 35 patients with white coat hypertension between the ages of 20 and 65 were included in this study. Patients with elevated office blood pressure (>= 140/90 mm Hg) and normal 24-h and daytime ambulatory blood pressure (<125/80 mm Hg and <130/85 mm Hg, respectively) were defined as white coat hypertension. Patient's sleep quality was evaluated using the Pittsburgh sleep quality index. Global Pittsburgh sleep quality index score was significantly higher in patients with white coat hypertension than normotensive subjects (7.2 +/- 3.7 vs. 5.1 +/- 3.8, P = 0.01). Poor sleep quality was present in 65% of patients with white coat hypertension, and in 30% of the normotensive group (P = 0.003). A multiple logistic regression analysis showed that white coat hypertension (odds: 6.7 (95% confidence interval [CI] 1.22-36.64), P = 0.03) and female gender (odds: 10.1(95% CI 1.35-76.32), P = 0.02) were independent predictors of poor sleep quality. In conclusion, white coat hypertension seems to be associated with impaired sleep quality.Öğe White Coat Hypertension and Poor Sleep Quality(ELSEVIER SCIENCE INC, 2013) Kaya, Zeynettin; Kayrak, Mehmet; Demir, Kenan; Gündüz, Mehmet; Alibaşiç, Hayruddin; Karanfil, Mustafa; Akıllı, Hakan[Abstract not Available]