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    Controlled Trial of Efficacy of Dexketoprofen in Sciatic Nerve Crush Injury in Rats
    (JOURNAL NEUROLOGICAL SCIENCES, 2014) Kaptan, Hulagu; Kasimcan, Omur; Ayaz, Murat; Bozdogan, Onder; Karabagli, Hakan
    Object: Local applications of Dexketoprofen trometamol (dex) have been shown to increase in the sciatic nerve functional tests following the nerve injuries. The aim of the current study was to compare the efficacy of dex application for 1 and 5 days following nerve injury rat model. Possible effects of dex were checked by means of the Sciatic Function Index (SFI), Withdrawal of the Reflex Leg (WRL), number of axons, axon diameter, and nerve diameters. Material Methods: The animal crushed model was done through Aesculap -Yasargil aneurysm method on Wistar albino (N=21) right sciatic nerves. In order to achieve desired purpose 3 experimental groups were organized: Group 1: control (injured and no drug); Group2: dexketoprofen 1 days (injured and single dose of drug); Group3: dexketoprofen 5 days (injured and single dose of 5 times drug applications). Injections were done through the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery of the sciatic nerves was evaluated with the improvement in the SFI values. Additionally, recovery of sensory function was assessed through WRL results and histopathological examination was performed 6 week following the injury. Results: At the end of the experimental periods there was no significant differences were found between the experimental group of animals on the bases of the number of axons, axon diameter, and nerve diameter. Moreover, up 30th day of the experimental period our functional test results have shown that there was no difference between the groups. But following the induction of the injury, the statistical significances were seen on the functional tests. This effect was seen only if the multi-dose application of the dex. Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, has revealed positive significant changes in the sciatic nerve injury through analgesic effect of it.
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    Correlation of low back pain caused by lumbar spinal stenosis and depression in women: a clinical study
    (SPRINGER, 2012) Kaptan, Hulagu; Yalcin, Esra Suer; Kasimcan, Omur
    Low back pain (LBP) due to spinal stenosis may be one of the most debilitating symptoms to decrease the quality of life. The cause and effect association of LBP and depression is vague. Pain may also be a somatization symptom of depression. This is more frequent in the female population. This clinical study was designed to evaluate the correlation between the level of back pain caused by lumbar spinal stenosis and depression in the female population. The study included 50 consecutive female patients with spinal stenosis. The stenosis diagnosis is made by neurological examination and neuro-imaging. The study group was psychiatrically evaluated and grouped as those with and without depression. Visual analog scale (VAS), Oswestry disability index (ODI) and Hamilton Depression Scale (HDS) were utilized in initial evaluation of the group. Twenty-one patients with lumbar spinal stenosis had depression (DLS Group) and 29 did not (LSS Group). Mean HDS scores were 8.97 and 32.48 for Group LSS and Group DLS, respectively. There was a statistically significant difference between the VAS scores of the groups (the mean VAS scores were 5.6 and 7.6, for groups LSS and DLS, respectively). The mean ODI values for LSS (65.24 +/- A 4.58) and DLS (75.1 +/- A 6.7) groups were also significantly different. In Group DLS, there were positive correlations between ODI and VAS with HDS (p < 0.001). Our findings indicated a relationship between lumbar spinal stenosis associated pain levels and depression. However, the cause and result relationship still needs to be established yet.
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    Lumbar Disc Hernia and Erectile Dysfunction
    (AVES, 2011) Kaptan, Hulagu; Kulaksizoglu, Haluk; Kasimcan, Omur
    Lumbosacral disc disease and sexual dysfunction are two non-lethal health entities that are common and decrease quality of life of patients. With interruption of communication between the brain and the penis, erectile dysfunction should be expected. However, there are very limited data on the interaction of lumbosacral disc disease and sexual functioning. The aim of this review is to highlight the association between lumbosacral disc disease and sexual dysfunction and to overview the diagnosis and treatment options for this subset of patients. (Archives of Neuropsychiatry 2011; 48 Supplement 1:31-4)