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Öğe Assessment of anxiety in subclinical thyroid disorders(JAPAN ENDOCRINE SOC, 2004) Gonen, MS; Kisakol, G; Cilli, AS; Dikbas, O; Gungor, K; Inal, A; Kaya, AIt is well known that manifest thyroid dysfunction causes mood disorders. In the literature there are few studies related with subclinical thyroid dysfunction and anxiety. We aimed to determine if there exists a relation between the anxiety and subclinical thyroid dysfunction. This study was carried out in the Meram Medical Faculty of Selcuk University, Department of Endocrinology and Metabolism. Eighty-five outpatients were enrolled into the study. In the presence of normal fT(3) and fT(4) patients were grouped as subclinical hyperthyroid with TSH lower than 0.1 mU/L (n = 24), subclinical hypothyroid with TSH higher than 4.5 mU/L (n = 32) and euthyroid subjects (n = 29). Beck's Anxiety Inventory (BAI) was administered to all patients. There was no any statistically significant difference between euthyroid and study groups in terms of age, gender, weight and height (p<0.05). One-way ANOVA showed that both of the subclinical hypothyroid and subclinical hyperthyroid groups had significantly higher anxiety scores than cuthyroid group (F: 11.4, p<0.001). Manifest hypothyroidism and hyperthyroidism, as causes of mental and neurological dysfunction have been known for a long time, but the relation between subclinical thyroid dysfunction and anxiety is less well studied. We have found that subclinical thyroid dysfunction increases the anxiety of patients whether hyperthyroid or hypothyroid. Overlap of symptoms common to both thyroid dysfunction and anxiety is an important limitation in this study. Mood changes especially anxiety due to subclinical thyroid dysfunction may have an important impact on the patient's quality of life. Negative effect on quality of life may be an indication of treatment in these patients. It is the first study evaluating anxiety in subclinical hypothyroidism in the literature.Öğe Dual ectopic thyroid gland with Graves' disease and unilateral ophthalmopathy: A case report and review of the literature(SPRINGER, 2004) Kisakol, G; Gonen, S; Kaya, A; Dikbas, O; Sari, O; Kiresi, D; Gungor, KEctopic thyroid gland (ETG) is a rare entity and can be seen anywhere in the route of descending gland. It is much rarer when encountered away from the midline. Dual ETG is such a rare entity that only a few have been reported in the literature. ETGs not only cause thyroid dysfunction, most commonly hypothyroidism and rarely hyperthyroidism, but also frequent local symptoms. Therapeutic options change according to patients' co-morbid diseases, age, size of goiter and presence of local symptoms. Graves' disease is very rarely detected in a patient with ectopic thyroid. There is no report in literature concerning ectopic thyroid presenting with Graves' disease and unilateral ophthalmopathy. We describe a case with dual ETG and Graves' disease and unilateral ophthalmopathy: it is the first reported in literature. (C) 2004, Editrice Kurtis.Öğe The Effect of Melatonin on Sperm Quality and Testicular Size of Normospermic and Pathospermic Rams in the Anoestrous Season(OSTAG-WERBUNG & VERLAG, 1998) Çoyan, K; Kaya, A; Karaca, F; Ataman, M B; Yıldız, CThe aim of this study was to investigate the effects of melatonin implants on sperm quality and testicular size of normospermic and pathospermic rams in the anoestrous season. The study was carried out on a total of fourteen Konya Merino rams. As a consequence of preliminary experiments, eight rams were found as normospermic and six rams as pathospermic. Both the normospermic and the pathospermic rams were divided into two groups with regard to spermatologic features and testicular size. Four normospermic and three pathospermic rams were treated with melatonin implant (Regulin(R)) and control groups were sham-treated. Semen samples of each ram were started to be collected after 5 weeks of the melatonin applications twice a week for 6 weeks. Semen samples were examined for volume, individual motility, sperm concentration, live/dead and abnormal sperm rates. Scrotal circumference and testes volume of the rams were measured within 15-day intervals during the study. Sperm motility and abnormal spermatozoon rates were found to be higher in the semen samples obtained from normospermic melatonin implanted rams than those of normospermic control rams. Significant variations in all spermatologic characteristics studied were found between pathospermic melatonin implanted rams and those of pathospermic control rams. Scrotal circumferences and testes volumes were found to be significantly higher in all melatonin implanted rams than in control rams. Our results indicated that melatonin implants have positive effects on sperm quality and increased the scrotal circumference and testes volume of both normospermic and pathospermic rams in anoestrous seasons.Öğe The effect of Sildenafil (Viagra((R))) on serving capacity of rams(B W K P R & VERLAG, 2005) Coyan, K; Kaya, AIntroduction The aim of this study was to investigate the effect of sildenafil administration on mating performance in the rams. Material and methods In a preliminary experiment, serving capacity of 21 Konya Merino rams was determined by pen mating test performed individually 3 times with 4 estrus ewes during a period of 1 hour. Based on the average number of mating in the preliminary experiment, 8 rams which had served 5 or less than 5 times were considered to be of low serving capacity. The other 8 rams which had served 7 and more than 7 times in an hour were considered to be of high serving capacity. In total 16 rams were selected for the further experiment. The other 5 rams which had served 6 times in the pen mating test were not considered for the further experiment. 1 hour before serving capacity evaluation, 4 rams from each group were treated intrarectally with 100 mg Sildenafil (Viagra (R)) homogenized in cocoa oil. The remaining rams from each group were treated only with cocoa oil and used as control. In addition to the total number of mating in an hour, rams were evaluated for the reaction time which is the time period between introduction and first mating. Results Sildenafil administration resulted in an increase in the total serving capacity of rams in both groups. The reaction time did not differ significantly. Conclusion Mating performance in rams is positively influenced by sildenafil. Further investigations are necessary to determine whether decreased libido could successfully be treated with this drug.Öğe The effects of scrotal insulation on bovine sperm morphology as determined by Fourier harmonic analysis and its relation to in vitro fertilization.(SOC STUDY REPRODUCTION, 2003) Geiger, LN; Enwall, LE; Kaya, A; Bergfelt, RS; Parrish, JJ[Abstract not Available]Öğe The effects of scrotal insulation on bovine sperm nuclear shape as determined by Fourier Harmonic analysis and its relation to in vitro fertilization.(SOC STUDY REPRODUCTION, 2005) Enwall, LE; Kaya, A; Geiger, LN; Schindler, JR; Orchard, JL; Northey, DL; Parrish, JJ[Abstract not Available]Öğe Gastric emptying in subclinical hypothyroidism(LIPPINCOTT WILLIAMS & WILKINS, 2005) Sari, O; Kisakol, G; Kayacetin, E; Kaya, AThe aim of this study is to investigate solid-phase gastric emptying in patients with subclinical hypotbyroidism and to compare it with healthy subjects. Twenty patients with a recently established diagnosis of subclinical hypothyroidism and 10 age-matched healthy subjects participated in this study. Gastric emptying half-time was calculated with solid food labeled with 250 mu Ci Tc-99m-sulfur colloid. There was no difference between serum free T-3 and T-4 values in both groups. Serum thyroid-stimulating hormone level was significantly higher in the subclinical hypothyroid group than in controls. Gastric emptying half-time was 123.94 +/- 18.58 minutes in the subclinical hypothyroid group and 101.80 +/- 25.56 minutes in the control group. These gastric emptying half-times were not different (P = 0.455). We suggest that in subclinical hypothyroidism, gastric emptying of solids is similar to that in age-matched healthy control subjects.Öğe Rhabdomyolysis in a patient with hypothyroidism(JAPAN ENDOCRINE SOCIETY, 2003) Kisakol, G; Tunc, R; Kaya, AWe describe a case of rhabdomyolysis associating hypothyroidism. Hypothyroidism frequently leads to myalgias, muscle stiffness, cramps and sometimes elevated levels of muscle enzymes, but rhabdomyolysis is quite rare. This report describes a case of rhabdomyolysis associating hypothyroidism in a 19-year old man. Muscle enzyme levels were typical of rhabdomyolysis. Muscle biopsy and electromyograpic findings were compatible with hypothyroid myopathy. Muscle functions completely recovered with levothyroxine therapy. The present case represents rhabdomyolysis secondary to undiagnosed hypothyroidism in a developed stage which manifests itself with rhabdomyolysis.Öğe Sperm binding to uterine and oviductal epithelial explants, zona pellucida, and fertilization capacity in vitro(SOC STUDY REPRODUCTION, 2004) Siddiqui, MAR; Brenny, SM; Kaya, A; Enwall, LE; Shamsuddin, M; Parrish, JJ[Abstract not Available]Öğe Testosterone secretion and semen plasma enzyme activity in rams with genital pathology stimulated with GnRH(ELSEVIER SCIENCE INC, 2002) Aksoy, Melih; Kaya, A; Vatansev, H; Tekeli, TTestosterone secretion in response to GnRH stimulation and enzymatic activity of semen plasma was evaluated comparatively in rams with or without genital abnormality. Scrota. testes and epididymides of 128 rams between 1.5 and 6 years old from various breeds were examined clinically and ultrasonographically. Bilaterally cryptorchid rams (n = 2), and rams with focal testicular degeneration (n = 3) or unilateral sperm granuloma localized in the caput (n = 3) epididymis or the cauda epididymis (n = 3). diagnosed by either clinical or ultrasonographic examination. were selected for the further investigation of spermatologic parameters, testosterone secretion in response to GnRH stimulation. and enzymatic activity of semen plasma before histopathologic confirmation of lesions. Except for the cryptorchid rams, sperm parameters determined in ejaculates were similar to intact controls (n = 3). GnRH administration increased plasma testosterone levels significantly irrespective of the type of genital pathology (P < 0.01). The testosterone response calculated based on area under the curve following GnRH administration in rams having genital abnormality was not significantly different from the controls. Aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activity in the semen plasma varied between rams. with the lowest mean values in the bilaterally cryptorchid group (P < 0.05). Spermatic granuloma localized either in the caput or cauda of the epididymis was associated with a significant reduction in the semen plasma AST activity compared to controls (P < 0.01). In conclusion, our results indicated that the ability of testicular tissue to secrete testosterone in response to GnRH stimulation in rains with bilateral cryptorchidisin, focal testicular degeneration and unilateral sperm granuloma was similar to that of intact controls. and that reduced semen plasma AST activity may have a diagnostic value in the diagnosis of the epididymal obstruction in rams. Focal testicular degeneration did not influence AST, alkaline phosphatase (ALP) and LDH activity in semen plasma. (C) 2002 Elsevier Science Inc. All rights reserved.Öğe Use of Fourier harmonic analysis of nuclear morphology of bull sperm to predict fertility.(SOC STUDY REPRODUCTION, 2005) Kaya, A; Xu, RF; Northey, D; Susko-Parrish, J; Parrish, JJ[Abstract not Available]
